211–220 of 395 posts
Daniel Okoro is NOT a science journalist - there are no other references to him online except for some Nigerian dude who doesn't match the article's profile. I also saw this on reddit - please keep Hacker News a safe spot :(
The article made up the claim it’s not from the paper itself. There was some improvement in cognitive scores, but no placebo group. Without a placebo group, there are a lot of explanations for the data.
They also quote a follow up study that sounds more compelling: > The 2026 multicenter placebo-controlled trial extending this work enrolled 240 participants with early Alzheimer’s... The intervention group showed slower decline on standard cognitive scales by about 30% versus placebo. But there's no such study in the references section. Not sure what's going on there but I want to see the data before I believe this.
https://arstechnica.com/health/2026/02/could-a-vaccine-preve...
Herpes simplex also increases Alzheimer's risk:
https://hn.algolia.com/?query=Herpes
But there is currently no vaccine for it.
Feedback about creatine often seems mixed. Many love it, but many also report problems. Just in this thread there are people talking about heart palpitations and sleep problems. I have the theory that these side effects and mixed experiences come from impurities of lesser quality products. Apparently there are mostly two sources: Creatine mono-hydrate which mostly comes from China and "creapure", which is a patented…
On the sleep deprivation topic, adenosine buildup in the brain is, along with melatonin, one of the brain's core sleep mechanisms. As you expend energy during the day, adenosine builds up, so your brain has an idea of how long you've been awake. Creatine recycles adenosine back into ATP, so less adenosine builds up. The amount of creatine you find in foods naturally is way less than the amount people are supplementin…
Direct link to the study: https://jpbs.hapres.com/htmls/JPBS_1766_Detail.html I wanted to check the dosages they used. Looks like the review includes studies ranging from 5g/day to 20-25g/day. (Typical dosage you'll see for daily use is 5 grams)
I use it as a supplement because I do weightlifting. 5g/day. I did 20g/day for a week once, and didn't notice it made any difference, so I'm back to 5g now. In terms of stuff like memory, mood, etc. I can't say it's made any improvement but the idea that it might be helping prevent decline is nice.
Earlier quoted context omitted.
I use it as a supplement because I do weightlifting. 5g/day. I did 20g/day for a week once, and didn't notice it made any difference, so I'm back to 5g now. In terms of stuff like memory, mood, etc. I can't say it's made any improvement but the idea that it might be helping prevent decline is nice.
For lifting you hit a saturation point quickly where your muscles will only hold so much of it. Not sure if there is an equivalent for any brain related effects.
Earlier quoted context omitted.
Sometimes when I see muscular guy with a head full of hair, I wonder what is counteracting that increased testosterone.
Sometimes people just have good hair and spend a lot of time in the gym. Even early 90s famous era mass monsters were not all bald. Baldness is known to be related to a bunch of things: testosterone levels, something to do with blood delivery to the scalp, deeper genetic factors. Surprsingly, for some of the cases scalp massage is known to help.
Direct link to the study: https://jpbs.hapres.com/htmls/JPBS_1766_Detail.html I wanted to check the dosages they used. Looks like the review includes studies ranging from 5g/day to 20-25g/day. (Typical dosage you'll see for daily use is 5 grams)
High dosage is not for your daily intake It’s called a loading phase to quickly saturate the tissues i.e for a week or so for someone who never took the creatine. You can absolutely skip this. I wouldn’t go higher than 10g daily on a regular basis. I personally take 7.5g for the last couple of years.
The article made up the claim it’s not from the paper itself. There was some improvement in cognitive scores, but no placebo group. Without a placebo group, there are a lot of explanations for the data.
Let's be real: I take a lot of edibles. I smoke sometimes on a hike. Every once in a while I get a Guiness and a gyro. My health is by no means perfect, and if I'm willing to take in literal poison (yes, alchohol is that dangerous that I say such things even about my precious Guiness).
Anyways, for years I've been mostly skeptical of vitamins. I've heard a megadose of Vitamin C can shorten the symptoms of a cold, but a "megadose" is relatively small enough that just some OJ can do that, no need for pills.
But if I'm not giving up my Guiness and gyros, I probably should be willing to be more flexible about my "no vitamins or weird supplements rule".
So TL;DR: Let's flip this around: What are the risks of creatine, presuming a safe supply chain? (It's legal where I am as far as I know, which I'm a fan of for most things since then you can get a receipt and there will be some authority that investigates if you're unlucky to get a "bad batch".)