An interesting anecdote that comes to mind is playing old computer games with arrow keys, which used my right hand. I got pretty proficient with this. Over the years, I (and I imagine many others) switched over to WASD to play newer games with mouse + keyboard, but this meant using the left hand for "arrow keys" Now I can directly compare how proficient I am with WASD vs Arrow Keys and the result surprised me. I was…
I'm right-handed, but I trained myself to use a mouse/trackball left-handed due to better ergonomics. I was getting back/shoulder pain and thought that it was related to computer use and realised that with the typical keyboard with numeric pad and a mouse setup, that my body was twisting more due to the mouse being more to the right than it needed to be. Using my left hand instead means less twisting as there's no numeric keypad on the left.
It took probably a couple of weeks to get comfortable with left-handed mouse use and these days, I am fairly ambidextrous on a computer.
The other thing that makes me think that handedness can be learned is learning to juggle. I found that it's easier to start doing a new movement (i.e. a trick) with my right hand, but once I learn it with my left hand, the left hand becomes more accurate than my right.