because coconut oil
and non-usa model diet is the key.
and its not making $ for the owners
Why has there been so little progress on Alzheimer's disease?
211–220 of 355 posts
Re: Why has there been so little progress on Alzheimer's disease?
#212They had a biological model. They had multiple drugs that were showed activity against that model, and effectiveness in humans. Problem was, the model was wrong. Pharma’s burned billions chasing this as it’s possibly the biggest market imaginable. Whether it was fraudulent or just incorrect is a different question. We don’t know all of the details of human biology. We don’t even know what all we don’t know. Most gues…
> Pharma’s burned billions chasing this as it’s possibly the biggest market imaginable. To be clearer, Pharma is chasing a nice long treatment plan, that will require expensive drugs till the end. Pharma does not heal - this is not good for business. So there are criteria around what they are searching for.
They want something that actually works, foremost. If the thing they sell doesn't work, then when someone figures out something that does work the thing that works will be preferred by the doctors.
Re: Why has there been so little progress on Alzheimer's disease?
#213Earlier quoted context omitted.
> Which illnesses have been cured? Diabetes, cancer? Chicken pox, polio, hepatitis C, dracunculiasis, yaws, malaria (on the way of it), tuberculosis, syphilis, everything that can be killed with antibiotics, rubella...
Remember a year or two ago when it was thought that measles was cured in the USofA? Halcyon days.
There is a cure though. What is happening is just that people are too stupid to use it.
Re: Why has there been so little progress on Alzheimer's disease?
#214Earlier quoted context omitted.
That’s not true. If you want to have a job at a prestigious institution then the research committees are pretty consistent in their biases.
The comment you were replying to was talking about funding. If you could develop a scientifically plausible model to defend the "burning fossil fuels is not so bad, actually" thesis, your funders would include the oil companies and the greater petrochemical industry. There is a lot more money to fund projects there than... anywhere else in the world, really, by a wide margin.
well oil companies funded "lead fuels are safe" research...
...and it really did backfire (in public relations, politics, etc)
now... I don't think they can actually fund 'research-for-their-profit' -- I mean, would you believe "petro is good for earth" research coming from oil companies, even after the 'lead is good or neutral' research?
Re: Why has there been so little progress on Alzheimer's disease?
#215Earlier quoted context omitted.
I think you are wrong, for several reasons. From the human perspective, researchers are people, and they do have their incentives. Making a breakthrough, of any kind, is important for them - even if for their career (but many do genuinely care and want to help humanity as a whole). From marketing and sales perspective, look at what happen to pharma companies capitalization when Ozempic appeared: a relatively small El…
I agree with you but Ozempic is a bad example here. Part of the reason it is so valuable is that patients usually must take it for the rest of their lives. Its actually the perfect example of “evil” pharma since patients slmost akways regain the weight if they stop taking it. This leads to dependence or people searching for grey market sources. An example of “good” pharma would be Hepatitis C. We can now cure that. A…
It's ridiculous to say that pharma is "evil" simply because it isn't a one time treatment, especially when you don't know if a one time treatment is even biologically possible. The water company isn't evil for failing to provide me a single glass of water that meets my lifetime hydration requirements.
Re: Why has there been so little progress on Alzheimer's disease?
#216Now that the “plaques are the disease” folks are having to listen to viable research in contradiction to them, there is a possible outcome that an mRNA vaccine for tooth decay ais also an mRNA vaccine for Alzheimer’s, if that particular theory pans out. Which would subtract a trillion dollars from GDP over a medium timescale. I remain hopeful :) but I’m not particularly holding my breath for the U.S. to invent a cure…
Do you have a link? A biotech company called Cortexyme already tried a drug against P. gingivalis , which causes gum disease, based on the idea that these bacteria migrate to the brain (many old people who died of AD have gum disease and tooth loss). But that drug failed phase II/III as there was no evidence of any effect.
Aw, drat.
Re: Why has there been so little progress on Alzheimer's disease?
#217[dead]
Re: Why has there been so little progress on Alzheimer's disease?
#218Re: Why has there been so little progress on Alzheimer's disease?
#219Earlier quoted context omitted.
Pretty clearly not. It would seem that beta amyloids correlate with Alzheimer's, but do not cause it. The problem us "consensus science". You could get funding to research beta amyloids, but not to research any competing hypotheses. It's much like climate science today: any dissent at all, even just questioning the predictions of catastrophe, immediately brands you as a heretic.
half the stuff currently in clinical trials is not targeting amyloids. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc...
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Re: Why has there been so little progress on Alzheimer's disease?
#220I might sound like a broken record, but dentistry is stuck in the past. Alzheimer's is basically an advanced form of gum disease caused by Porphyromonas gingivalis) that has infiltrated into your jaw and then traveled into your brain where it causes systemic inflammation which in turn lets other pathogens in that cause neurodegeneration. There is probably no cure because the only thing you can do in dentistry is prev…
It may be one source of the disease, but it is almost certain it isn't the only source.