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Peptides: where to begin?

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Re: Peptides: where to begin?

#211

Post by aucisson_masque »

JumpCrisscross wrote: post #137

> a patient who is discontinuing her statin therapy - very inadvisably, given the clinical presentation described - but is enthusiastic about “BPC-157” This feels new. I thought the methylene-blue-for-cancer types continued their medicine while taking other things as extras. Personally, I've swung over to the laissez-faire side of medicine. At the end of the day, if you're an adult, it's your body. You should be give…

Exactly my point of view. Medications are like drugs, if we failed to forbid it we might as well allow it but regulate it, aka make seller accountable for the purity.

Re: Peptides: where to begin?

#212

Post by IsTom »

ggm wrote: post #182

I'm here for two probably contradictory comments. The first is collagen: I'd love to see Lowe's take on recent peer review which says boosting oral collagen does appear to show signs of improved joint pain and skin resilience. Obviously modulated through how protein deprived you are, but for older people, eating enough protein can be an issue: it's not rapidly absorbed so you need 3 squares a day to get to the higher…

> you need 3 squares a day to get to the higher numbers.

> Collagen powders

In that case if you're eating collagen powder you could be eating just regular protein powder then?

Re: Peptides: where to begin?

#213

Post by arjie »

I used retatrutide for weight loss and went from 199.3 lbs to just under 175 lbs. I kept daily notes through the process. Here's a quick AI one-paragraph summary if you're curious: https://pastebin.com/XACNYKvs

Overall I'm quite pleased with the effects and many of the properties of this treatment that people dislike are actually properties I was looking for. Essentially, for pharmacological interventions I want impermanent effects with a clear dose-response relationship and ideally minimal or no adaptation.

So the fact that people gain weight when they go off it and then lose weight again when they go on it was good. That meant it's fairly easily undoable. The fact that the more you take the more you lose also was pretty good to know though for the majority of the time I took less than any tested dose (and the effects were quite strong on those).

I did experience quite a bit of adaptation so I needed to up the dose until I was in the range tested by the end. I've been off it for a month now and been pretty much flat, but we've been traveling since I stopped and so a lot has changed (no more lifting, lots more eating, lots more walking).

Rough cost for the retatrutide is $1.25/mg.

Re: Peptides: where to begin?

#214

Post by ramraj07 »

ben_w wrote: post #171
ramraj07 wrote: post #168

Earlier quoted context omitted.

Im sorry for your quality of life problems but calling doctors bad at statistics and then giving anecdotal evidence as proof has to start ringing some logical bells right? You dont even have to take our word. Use an LLM as judge. Paste your comment into chatgpt and see what it says.

> Paste your comment into chatgpt and see what it says. Isn't one of the bigger problems with ChatGPT that it's much too supportive of whatever the human is talking about?

Thats the point. If even such a sycophantic ai disagrees with your points you have a problem

Re: Peptides: where to begin?

#215

Post by JumpCrisscross »

rzmmm wrote: post #208
JumpCrisscross wrote: post #142

Earlier quoted context omitted.

> they are ineffective outside clinical trial setting for treating obesity This is totally false. I know a number of people who took GLP-1 to treat their obesity and then stopped and have stayed not obese.

I can't reply elsewhere so I will reply to this again. > In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to. Out of curiosity, what sources lead you to believe this? Anecdotes like this are interesting but in medicine they are not sufficient to make factual statements about drugs. In meta-analyses there is weight regain which is steeper as more weig…

> In meta-analyses there is weight regain which is steeper as more weight is lost during treatment

What does "steeper" mean? The studies I've seen show a net weight loss, even after regain, for the median patient.

> The weight regain seems to be rather slow, it can take years until the baseline weight is reached

Maybe. Right now, however, the evidence shows solid effects outside clinical settings. Your original statement was wrong–your sources own refute the claim.

If you're arguing the effects in the real world haven't consistently been as ridiculous as they were in clinical trials, sure, you get a brownie point. But broadly speaking, these drugs are terrifically effective, both when taken for life and when taken intermittently.

Re: Peptides: where to begin?

#216

Post by anukin »

picafrost wrote: post #187

[flagged]

I have recently been through the rabbit hole of peptides and most of the people engaged or involved in peptides seem to be healthy individuals. There are some exceptions like lookmaxxers and anti vaxers. The vast majority of people are normal and majority are outside of USA where anti vax sentiment are not in vogue. Some explore peptides for their dogs and cats too.

To assert that people are sad and anxious while not putting the effort to understand the people involved is such an intellectually lazy position to hold.

Re: Peptides: where to begin?

#218

Post by EiZei »

arjie wrote: post #213

I used retatrutide for weight loss and went from 199.3 lbs to just under 175 lbs. I kept daily notes through the process. Here's a quick AI one-paragraph summary if you're curious: https://pastebin.com/XACNYKvs Overall I'm quite pleased with the effects and many of the properties of this treatment that people dislike are actually properties I was looking for. Essentially, for pharmacological interventions I want impe…

> Rough cost for the retatrutide is $1.25/mg.

Even with free healthcare that seems like a foolish place to save money when very widely used alternatives exist in the regulated market.

Re: Peptides: where to begin?

#219

Post by flexagoon »

ggm wrote: post #182

I'm here for two probably contradictory comments. The first is collagen: I'd love to see Lowe's take on recent peer review which says boosting oral collagen does appear to show signs of improved joint pain and skin resilience. Obviously modulated through how protein deprived you are, but for older people, eating enough protein can be an issue: it's not rapidly absorbed so you need 3 squares a day to get to the higher…

For the first one, I assume you mean a systematic review, not a peer review? I guess you're talking about this one:

https://pmc.ncbi.nlm.nih.gov/articles/PMC10180699/

It has a Mechanism section which explains that when collagen is digested, one of the products of that is Gly-Pro-Hyp, which is what has the effects. I don't think that conflicts anything in this post?

Re: Peptides: where to begin?

#220

Post by simonklitj »

BoggleOhYeah wrote: post #217
picafrost wrote: post #187

[flagged]

The world is full of people that confuse contrarianism for intelligence. HN, in particular, loves anything that allows them to discredit science (like the constant banging on about the replication crisis) and replace it with their own pet theory.

Is HN particularly drawn to this over other platforms? I gotta say I don’t quite recognize this. In general, I think there’s a good dose of respect for science around these parts, but maybe I’m blind to it.
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