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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#211

Post by tjader »

throwawaylaptop wrote: post #206
tjader wrote: post #203

Earlier quoted context omitted.

It is only thermodynamically impossible if you assume 100% efficiency in energy extraction from food, but in practice we only extract a very small amount of energy from matter. Thermodynamically you could extract ~10^12 kcal from a Pop Tart if you converted its mass into energy. Not that I agree that for a human metabolism meal timing makes much of a difference in energy extraction, but it wouldn't be thermodynamical…

It's insane to me that people keep talking about the energy in part. Forget that. Realize that WHAT you put in can change what energy out is. If I gave you 1800 calories of vodka at 8am, would your use the same amount of energy during the day, and even make it to your 7pm gym? No. Ok, well sugar isnt exactly the same obviously, but it can also affect what you do that day, how your body acts, your brain even. Your ene…

Yes it can affect what you do. That's the calories out part of the equation.

Nobody claims that the quality of what you eat has no effect on you, but every study shows that if you maintain the same calorie intake and expenditure it doesn't really matter how you consume the calories or how you expend it.

Re: Ozempic shows anti-aging effects in trial

#212

Post by c4ptnjack »

genewitch wrote: post #73
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

every time in recorded human history when there's be a panacea or cure-all it's generally been snake-oil. There are a lot of side effects, of this type of medicine - many which were not really prevalent when it was prescribed on-label.

Wouldn't the side effects, combined by the accompanying lifestyle changes key to making this medication most effective, show its not a panacea or cure-all? The fact there are these second order effects with such incredible impacts would lead me to believe its more mechanistic than magical with how much obesity effects all sorts of body systems

Re: Ozempic shows anti-aging effects in trial

#213

Post by SturgeonsLaw »

jjice wrote: post #139
matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

I've heard similar for gambling, and as one of the sister comments said, things like video games. I'm so curious to understand _why_ that effect is there, but I've heard this so many times now that I do believe that it exists in some capacity. Such an interesting world we're opening up here.

I wouldn't speculate on the cause of action, however all those activities are linked by activation of the dopaminergic reward circuit, so semaglutides might have some broad based anti-addiction properties by moderating dopamine activity.

Re: Ozempic shows anti-aging effects in trial

#214

Post by c4ptnjack »

mullingitover wrote: post #135
matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

The cynic in my thinks this will its undoing. Some huge fraction of alcohol profits come from a small portion of drinkers. If these G* peptides help these poor people their drinking under control, it would take a huge wrecking ball to the profits, and thus to the taxes. Can't have that.

I think you over estimate the liqour lobby and underestimate how much of alcohol profits likely come from luxury purchases

Re: Ozempic shows anti-aging effects in trial

#216

Post by c4ptnjack »

throwawaylaptop wrote: post #185
radiofreeeuropa wrote: post #173

Earlier quoted context omitted.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

[flagged]

The zeitgeist has pushed the idea carbs/grains and sugar are terrible over the last 40 years on and off, so that seems to say more about the medical industrial complex, than anything. That's fair, but if that message has been pushed so consistently, why didn't we see a real decrease in the consumption of those things and the associated weight loss?

Re: Ozempic shows anti-aging effects in trial

#217

Post by aydyn »

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

> find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain.

Its just inductive reasoning. Most things are not free, let alone miracles. Nearly everything in life has a cost.

Re: Ozempic shows anti-aging effects in trial

#218

Post by throwawaylaptop »

tjader wrote: post #211
throwawaylaptop wrote: post #206

Earlier quoted context omitted.

It's insane to me that people keep talking about the energy in part. Forget that. Realize that WHAT you put in can change what energy out is. If I gave you 1800 calories of vodka at 8am, would your use the same amount of energy during the day, and even make it to your 7pm gym? No. Ok, well sugar isnt exactly the same obviously, but it can also affect what you do that day, how your body acts, your brain even. Your ene…

Yes it can affect what you do. That's the calories out part of the equation. Nobody claims that the quality of what you eat has no effect on you, but every study shows that if you maintain the same calorie intake and expenditure it doesn't really matter how you consume the calories or how you expend it.

Well then luckily that shows you hopefully how bad studies are. Because I assume that you agree that eating 100 calories of Pop-Tarts per hour for 18 hours for 30 days, would give you a different result than eating 3 days worth of Pop-Tarts in a few hours once every 3 days for a month.

To not understand that would mean that while believing some studies, you completely ignore all the studies that have been done on insulin and weight gain.

Re: Ozempic shows anti-aging effects in trial

#219

Post by tjader »

throwawaylaptop wrote: post #218
tjader wrote: post #211

Earlier quoted context omitted.

Yes it can affect what you do. That's the calories out part of the equation. Nobody claims that the quality of what you eat has no effect on you, but every study shows that if you maintain the same calorie intake and expenditure it doesn't really matter how you consume the calories or how you expend it.

Well then luckily that shows you hopefully how bad studies are. Because I assume that you agree that eating 100 calories of Pop-Tarts per hour for 18 hours for 30 days, would give you a different result than eating 3 days worth of Pop-Tarts in a few hours once every 3 days for a month. To not understand that would mean that while believing some studies, you completely ignore all the studies that have been done on ins…

> Because I assume that you agree that eating 100 calories of Pop-Tarts per hour for 18 hours for 30 days, would give you a different result than eating 3 days worth of Pop-Tarts in a few hours once every 3 days for a month.

I agree that you would feel very differently in those situations and it's likely you wouldn't spend the same amount of energy unless you really make an effort to do it.

I don't agree that if you do make an effort to spend the same amount of energy you would have different results with regards to weight loss.

Re: Ozempic shows anti-aging effects in trial

#220

Post by Aurornis »

cm2187 wrote: post #147
Aurornis wrote: post #118

Earlier quoted context omitted.

> And also the idea that it is "easy" to lose weight is completely out of touch. If it was there wouldn't be millions of people trying hard, spending money on trying and failing for decades, and entire businesses addressing that. This is a touchy topic, but I would like to point out that you're missing the obvious confirmation bias that comes with this observation. There are many people who modulate their weight by c…

and there are people who don't get fat no matter what they eat. Not sure what difference it makes to the millions of people I am refering to. Not even sure what is your point.

> and there are people who don't get fat no matter what they eat.

This is a myth.

When you actually track what these people eat, their daily caloric intake averages out to numbers you'd expect. At best, the difference between "fast metabolism" and "slow metabolism" people in studies comes out to a couple hundred calories per day.

You may witness someone consume 2 pizzas and a soda in one sitting without getting fat, but that person is consuming fewer calories for the rest of the day or the week to offset it.

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