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Brain waves appear to wash out waste during sleep in mice

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Re: Brain waves appear to wash out waste during sleep in mice

#211

Post by BenFranklin100 »

One of the traits/habits I’ve been fortunate to have/cultivate is daily afternoon napping. I can rest my head and fall asleep in minutes and then wake back up 15 minutes later feeling cognitively refreshed. I’ve done this since my teenage years and throughout adulthood.

Short, intentional, regular napping is associated with a lower risks of dementia. This is different from increased, longer, napping seen in older adults. Longer naps in older adults is associated with Alzheimer’s. See this summary:

https://www.alzdiscovery.org/cognitive-vitality/blog/can-nap...

It will be interesting to see if further research in humans can pinpoint a plausible causal mechanism in adult for both regular night time sleep and intentional short daytime napping. This might encourage companies to put in ‘sleep pods’ or at least remove the stigma of adult napping.

Re: Brain waves appear to wash out waste during sleep in mice

#212

Post by theaussiestew »

greggsy wrote: post #2

Is anyone more knowledgeable able to interpret the paper beyond ‘brain waves wash toxins’? Are they actually responsible for the observed activity, or do they merely trigger some ‘flushing’ mechanism inherent to the cells? Or, are the waves a result of that process?

In another comment I talked about how I observed a phenomena similar to the one described where neuronal activations would create waves, I've quoted it here. I would summarize it as 3D waves of light, resulting in a spherical enamation that readjusts the physical substrate of the mind and body.

""

I tried to observe the phenomena yesterday again and couldn't observe it but it was very specifically this in the past: spherical orbs of white light expanding from a centre. There were many of these, and my perception was that the nature of this geometric expanding shape was healing. To describe it more clearly, many years ago I felt that the perfect geometric spherical nature of these expanding waves were designed to gently round off rough edges. To make an analogy, imagine kneading some play dough over and over again. When you use your hands to do so, every time your hands make contact with the play dough, the play dough changes shape slightly because of the contact between your hands and the play dough and it gets softer. Now apply this concept to the idea of energetic waves making contact and passing through the material substrate of the brain and the rest of the body (yes I observed the waves applying to more than just my mind). It was my physical and conscious perception that as the spherical waves emanated from some center, they gently readjusted the physical substrate that they passed through. And because there were so many of them in different spatial locations, this readjustment was incredibly refined.

Re: Brain waves appear to wash out waste during sleep in mice

#213

Post by Terr_ »

moffkalast wrote: post #209
Terr_ wrote: post #189

Earlier quoted context omitted.

If there is any magic bullet, it'll be something biological evolution can't easily jump-to or stumble-upon. Otherwise I think it would have happened already, given the risks of sleep and the rewards of an expanded activity (or at least awareness) cycle.

Well it's not unheard of that some people won the genetic lottery and are more efficient at it, functioning normally with only 3, 4 hours of sleep every day. There's definitely room for improvement for those of us that need 8 or 9 lmao. Hell even reducing it to just 7 or 6 would be such a massive gain.

For "Short Sleeper Syndrome", it remains to be seen what the long-term tradeoffs are.

Kind of like how someone might excel at a specific test because of a lesser sense of pain, but that lack of feedback loop can be detrimental in the long run as they keep injury themselves without noticing.

Re: Brain waves appear to wash out waste during sleep in mice

#214

Post by euroderf »

BenFranklin100 wrote: post #211

One of the traits/habits I’ve been fortunate to have/cultivate is daily afternoon napping. I can rest my head and fall asleep in minutes and then wake back up 15 minutes later feeling cognitively refreshed. I’ve done this since my teenage years and throughout adulthood. Short, intentional, regular napping is associated with a lower risks of dementia. This is different from increased, longer, napping seen in older adu…

I find that even just 2 or 3 minutes unconscious still helps a lot. The Minimum Viable Nap is pretty minimal.

Re: Brain waves appear to wash out waste during sleep in mice

#215

Post by euroderf »

ww520 wrote: post #156

Sounds like the brain is doing garbage collection during sleep.

Try this metaphor:

Your brain is a movie theater. When it's in use it's all bright lights and gripping soundtrack and shiny shiny. But once in a while you have to chase out the Observers and shut down the projector and then go grab a hose and ruthlessly flush out all the tracked-in mud and popcorn remnants and stepped-on gummy bears and who the hell knows what other gunk.

Re: Brain waves appear to wash out waste during sleep in mice

#216

Post by samstave »

0xFEE1DEAD wrote: post #88
samstave wrote: post #45

Earlier quoted context omitted.

I wonder if this state could be ultrasonically induced to have a "sleep helmet" which can calm and align rhythmic waves? and induce an artificial flush or "power nap" -- Well, thats basically the trope of every Cybernetic design, with the connectors comming out the back of head/spine... Like a continual wash which keeps you in this suspended hyper-aware, but calm, rested and focused mental state. This is why cyborgs…

Have you seen the video on hn a couple of weeks ago about the scientist using ultrasound to halt the progression of Alzheimer’s and to treat addiction? Most fascinating video I’ve seen in a long time. Edit: If you haven’t seen it yet, I highly recommend checking it out https://youtu.be/7BGtVJ3lBdE

Thanks! Super interesting... however - I think our understanding of how to properly aim it, and make it resonant in the same way that mythical ancients a read to as have - We dont yet understand the frequencies of being.

Re: Brain waves appear to wash out waste during sleep in mice

#217

Post by LoganDark »

plasticchris wrote: post #208
LoganDark wrote: post #162

Earlier quoted context omitted.

You're describing sleep paralysis, right? It's not so much a disconnection as it is an inhibition. Attempts to move most of your muscles are blocked, but external stimuli still get in. You know, once upon a time someone started the washer while I was presumably in REM, and I started to hear something in my dream. When I woke up, it only took me a couple minutes to realize that what I had been hearing in the dream was…

Yeah, that’s right. I had it once before I knew it was a thing and could see, hear, feel, but not move. Quite terrifying at the time, even if it resolved pretty rapidly.

I've been trying to induce it willingly for around a decade at this point. Same for lucid dreaming. Haven't really managed to do either one, not sure if I am capable of it either. Oh well.

Re: Brain waves appear to wash out waste during sleep in mice

#218

Post by vanattab »

pdntspa wrote: post #173
thatcat wrote: post #158

Earlier quoted context omitted.

Has she tried cannabis? It prevents dream memory formation and can help with nightmares

In my experience you need a pretty high tolerance and smoke pretty regularly for it to start preventing dreaming. When I intentionally reduced my tolerance to very low levels I started having dreams again.

The reason you don't dream is it prevents the rem cycle. It might help in falling asleep but your sleep quality suffers.

Re: Brain waves appear to wash out waste during sleep in mice

#219

Post by swed420 »

whimsicalism wrote: post #182
pdntspa wrote: post #173

Earlier quoted context omitted.

In my experience you need a pretty high tolerance and smoke pretty regularly for it to start preventing dreaming. When I intentionally reduced my tolerance to very low levels I started having dreams again.

i mean if you are consuming daily in the evenings you will develop a high tolerance

As someone with a tolerance, I've learned that consuming too close to bedtime will cause me to have difficulty falling asleep, and also not enter REM sleep.

However, by consuming throughout the day on a daily basis but stopping by late afternoon or early evening, my sleep and dreaming is vastly improved.

Re: Brain waves appear to wash out waste during sleep in mice

#220

Post by samstave »

QuantumGood wrote: post #200
magicalhippo wrote: post #155

Earlier quoted context omitted.

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

Promethazine (1) helps some people, myself included (UK Sominex). And occasionally, phenibut. (1) https://www.inhousepharmacy.vu/p-1189-phenergan-tablets-25mg...

Promethazine the Proud! Flamer of Flames! Gayest of Gallopers!!!

Sounds like the name of a Centaur Character in any D&D style game.

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