Just came off benzos withdrawal those things are insanely horrible, delirium, depersonalization, derealization, muscle tremors, and persistent headaches were some of the symptoms I experienced. Thank God I did not have seizures.
Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
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Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#212Earlier quoted context omitted.
SSRI-like drugs and drugs like buspirone are considered the gold standard for anxiety disorders now. They do not act like benzodiazepines at all in the brain.
How do they act? I just started taking buspirone for crippling social anxiety and I’m not sure if it’s helping or not.
Newer SSRI-like drugs that block the serotonin transporter and activate 5HT1A also exist, combining the actions of both drugs.
It typically takes serotonin receptors about two weeks to downregulate, and possibly even months to see any effects on depression and anxiety. Buspirone is not like benzodiazepines that work pretty much instantly, but it doesn't come with any of the risks benzodiazepines do.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#213Earlier quoted context omitted.
> I tell everyone to never take benzos for any reasons You can't generalise your experience. Everybody is different and that's the doctor's job to assess whether the benefits outweigh the cost, considering the patient and their problems. Personally, I've been taking benzos very occasionally for 20 years (never more than a few days at a time) and they helped me overcome difficult times. Never had the slightest addicti…
Agreed, I have pretty bad social anxiety with hypervigilance. Taking on average 3 5mg (occasionally a 10mg dose) tablets a week when needed for presentations or meetings with more weight allows me to keep my job. Even such a small dose I feel restores a sense of normality that I haven't experienced in over 10 years without them, I'm able to rationalise what I want to say, conversation flows, I feel in control. With a…
Propranolol blocks the physical symptoms of anxiety. It stops your hear rate and blood pressure from rising. It stops those uncomfortable adrenaline rushes. It stops stress-induced trembling / shaking.
It's completely safe, any doctor will happily prescribe it, it's not addicting, and unlike benzos, it doesn't affect your cognition.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#214Earlier quoted context omitted.
I got to see this side of American medicine while in high school. My great aunt unofficially overdosed on a cocktail of drugs prescribed by a group of loosely coordinating doctors. When she passed, her cocktail included 12 prescriptions. One of her doctors had prescribed her medication to lower her blood pressure while another had her on medication to raise it.
Ouch. People are really bad at handling their own medical care. I’m legitimately on 8 different medications and 3 supplements (not including vitamins), per doctor’s instructions. There is no way I’m going to any appointment (including my dentist) without a printed list of everything, including the dosages, instructions, and reason for being on it. Edit: I apologize for the poor phrasing. It comes off being flippant.…
I propose we call them, "Doctors," from the Latin word for "teacher," by reference to their role in instructing patients on the things they need to know about their health.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#215Earlier quoted context omitted.
is that a question? Benzos are not safe despite what many doctor believe. I'm in EU.
In my opinion doctors underestimate the danger of benzos. They also often don't know that there is a black market for benzos (like there is for any other drug). Patients will be able to find benzos if they look for them even if they don't have a prescription. I had a friend who wanted to stop smoking cannabis and got alprazolam prescribed for that by his doctor (it was in EU). In my opinion it would be better to stic…
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#216Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#217Earlier quoted context omitted.
This is a exactly the kind of puritanical catch-22 that entrenches every corner ADHD treatment. “Oh, your justification for access to the high-inducing , party drug of amphetamine is that it’ll cure your lack of focus? Well, if these dangerously addictive drugs so effective, then surely you can handle 30 day prescriptions with no refills.” God forbid your prescription runs out on a weekend or holiday when your doctor…
100% this. The worst part about ADHD treatment is all the disruptions of care to prevent people trying to abuse it. I personally don't give a rat's ass if people want to take adderall to go out and party or masturbate either. They'd probably have fun with less negative health effects or risk of fights/belligerence compared to alcohol... But for some reason the government (the FDA) and medical field in general cares a…
I got turned down for filling an Adderall prescription at a CVS because the pharmacist didn't like that I was paying in cash (credit card) as an uninsured uni student. Didn't offer to call my doctor's office to confirm the script. Just said oh, I don't like that you're paying in cash so I'm not going to fill this :).
I fortunately get 90-day prescriptions (how long will that last?) and every time I refill, I have anxiety throughout the whole process (the checkup, the pharmacy) until I have pills in hand. Every time I feel like it's going to be the day I somehow have to jump through more hoops like my friend who has to have his pills counted every two weeks for his painkillers.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#218My doctor very thankfully instilled a level of fear and skepticism in me from day one when he prescribed them, explaining that while they were a viable option for me in the moment, the effect begins permanently wearing off very quickly. They got me through some stuff but I was happy to stop taking them and hope I never am at the point where I need to consider them again having heard where it so often goes for people.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#219Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#220I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…
For people with anxiety and panic attacks, benzo’s are literal lifesavers.