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Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

merck.com

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Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#211

Post by ashtonkem »

photochemsyn wrote: post #55

Some interesting points on the nature of our pharmaceutical patent system... (and while the cohort in this study does seem a bit small, the conclusions appear to be fairly valid): > "Molnupiravir was invented at Drug Innovations at Emory (DRIVE), LLC, a not-for-profit biotechnology company wholly owned by Emory University, and is being developed by Merck & Co., Inc. in collaboration with Ridgeback Biotherapeutics." >…

The phase III trial was cut short at the recommendation of the independent monitoring board. Apparently the effect was so strong they recommended seeking Emergency Use Authorization earlier, rather than waiting for the trial to finish, presumably so that they could save more people’s lives who might get sick and die waiting for trials to finish.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#212

Post by ashtonkem »

rsynnott wrote: post #165
rory wrote: post #86

Earlier quoted context omitted.

Is 40% adverse reaction to a placebo typical? Really makes me wonder how many "side effects" are in our heads..

Given that this is a drug that's only given to people who _have covid_, I'd say it's incredibly difficult to disambiguate from covid symptoms.

Covid and at least one comorbidity. 14% of the control group died; it’s no surprise that 40% had some sort of bad reaction, since presumably they were in pretty bad shape overall.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#214

Post by barbazoo »

raphlinus wrote: post #189
barbazoo wrote: post #178

Earlier quoted context omitted.

I'm curious to know if there are studies involving actual Covid-19 cases being treated with Ivermectin. If not, why? If yes, what are the results?

Yes, there are 14 studies that met the criteria for inclusion in the Cochrane review of Ivermectin. The results are mixed (some show a bit of improvement) but overall weak. In addition, ACTIV-6 is a massive (15,000 participant) study that will study Ivermectin and two other repurposed medications. Because that study is large and rigorous, it will basically answer the question of whether Ivermectin works and how well.…

I'll definitely look at and follow those, thanks.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#215

Post by ashtonkem »

kortex wrote: post #188
barbazoo wrote: post #162

Disclaimer: I'm not promoting Ivermectin here, don't get me wrong. I just want to cover my bases as this announcement is definitely going to be used by people to support their conspiracy theory. Earlier this year Merck the manufacturer of Ivermectin issued this [0] statement saying that Ivermectin isn't useful for preventing/treating Covid-19 and people shouldn't take it. Some people explained that with the fact that…

The problem is that if the in-vitro studies are correct on their dose curves, then the majority of the human trials are at ineffective doses. This doesn't mean they must be wrong, but it's not a good look. If the studies were showing unequivocal benefit, we could overlook the dose curves. But the studies are still quite equivocal. On the other hand, molnupirivir is a nucleoside polymerase inhibitor, with a slam-dunk…

Those in vitro studies were done with Vero cells, from the kidneys of a green monkey, which do not appear to be a good analogue for human lung cells with Covid. Even if you could give the Ivermectin doses recommended by the study without killing the patient, chances are it wouldn’t actually work.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#216

Post by mywittyname »

sjg007 wrote: post #132
photochemsyn wrote: post #55

Some interesting points on the nature of our pharmaceutical patent system... (and while the cohort in this study does seem a bit small, the conclusions appear to be fairly valid): > "Molnupiravir was invented at Drug Innovations at Emory (DRIVE), LLC, a not-for-profit biotechnology company wholly owned by Emory University, and is being developed by Merck & Co., Inc. in collaboration with Ridgeback Biotherapeutics." >…

You can thank Bob Dole for that wrt patents from Federal research funds.

TIL.

I'm slowly learning that, when the government has a choice between and obvious, smart way of operating, and a clearly dumb way. They choose the dumb way because some chucklefucks in Congress made it illegal to operate the smart way.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#217

Post by ashtonkem »

xxpor wrote: post #130
rossdavidh wrote: post #100

Earlier quoted context omitted.

I believe the reason the trial was in unvaccinated people, was so that it would have a big enough signal to detect quickly. If you did the same trial with vaccinated subjects, it might still be making a 50% reduction in hospitalization, but it would take a lot longer to detect that. I don't think the idea is to only give it to the unvaccinated.

I'd love to talk to someone who refused to get vaccinated but gave their informed consent to participate in this trial. Kind of boosts my personal theory is that a lot of vaccine hesitancy is driven by the fact that it's an injection and if it were a pill instead people would be more willing to take it.

Your theory is entirely possible. But I’d also like to point out that the study population was entirely Covid positive people with one or more risk factors. Presumably if you’re overweight, over 60, and have Covid you probably are willing to take more risks than before to improve your odds of not dying. Even the vaccine hesitant might accept that risk.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#219

Post by EricE »

helloguillecl wrote: post #150
dougmwne wrote: post #54

Earlier quoted context omitted.

Thank you for weighing in. I am hugely excited about this and immediately sent a message to all my family. I know people who died because they didn't know that antibody treatments were available and effective when given early enough. I very likely saved my own father's life by helping him to get an antibody treatment when he and his own doctor knew nothing about it at the time. When we're talking about pre-hospitaliz…

Would you mind to share which antibody treatment were you able to get for your father? I would be useful for the rest of us if we ever find ourselves in this situation again.

There are actually a multitude of treatments beyond waiting for thing to get bad enough that you need to go to the hospital: https://aapsonline.org/covidpatientguide/

This is also worth a watch: https://www.youtube.com/watch?v=QAHi3lX3oGM

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#220

Post by _holographic_ »

There has never been a disease in history where the official guideline was to stay at home until you can´t breath anymore. Doctors around the world who treat this virus EARLY with off patent drugs like ivermectin have very good results (as good as the ones announced here). The western world has utterly failed in this pandemic.
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