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Moderna mRNA sequence released to GitHub [pdf]

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Re: Moderna mRNA sequence released to GitHub [pdf]

#211

Post by vmception »

anyfoo wrote: post #35
vmception wrote: post #4

Earlier quoted context omitted.

We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact But for now we can inject code to trigger protein configuration via the immune system

> We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact Except it is unfortunately not that simple, because it assumes that distinct components such as CPU, co-processors and even logic gates exist in that context, as is totally reasonable to assume on devices created by humans. Abstracting complex machines into distinct components i…

I am not able to draw the distinction you are trying to make. The more we make machines, especially ones to interact with inputs from our world, the more easy it is to understand our bodies.

Correct, because there is no blueprint then we don't know about how the brains and neurons interact. But if there is a problem with a heart valve we know exactly where and why it failed.

I expect greater convergence in these fields, and as such I can't agree with you.

Re: Moderna mRNA sequence released to GitHub [pdf]

#212

Post by ceratin6 »

drtz wrote: post #31

I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears_. I get the feeling that this is something I have a better chance of understanding than the average SaaS Terms and Conditions. I expected to have to scroll through pages upon pages of indecipherable text. Instead it's no bigger than a large paragraph of text, and I can easily fit it on my screen.

> I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears

The genetic code is simple. But possibly not the nanobot that I felt like attached to my optical nerve with a slightly painful prick behind my right eye.

I’m not kidding. I never have eye pain and within a day or two of my vaccination, I had a prick feeling once in the back of my right eye, later accompanied by light coming from within my eye as it was closed in the dark for only a monent for a small part in or close to the middle of my visual field.

I wish I was making this shit up. It was really the only weird side effect, coincidental or not, of the vaccine for me.

The good part is that my vision in that eye has been slightly better since.

I’m not recommending not to get the vaccine. You should get it. But this experience was weird enough to share.

I had a fleeting thought of buying an eyepatch for privacy.

Re: Moderna mRNA sequence released to GitHub [pdf]

#213

Post by mikehollinger »

ethbr0 wrote: post #195
mikehollinger wrote: post #167

Earlier quoted context omitted.

Reading the primary claim is fascinating: "A composition, comprising: a messenger ribonucleic acid (mRNA) comprising an open reading frame encoding a betacoronavirus (BetaCoV) S protein or S protein subunit formulated in a lipid nanoparticle." I have a "I'm sure that means something to somebody" feeling. It's also surprising that the remaining claims seem to describe the resulting bits of the sequence, and that that…

It's an interesting structure, but probably partly out of patent law. To wit, SARS-nCoV-2 is non-patentable, being of natural occurance. But a specific composition that encodes its spike protein, encapsulated in a lipid nanoparticle? That's much more of a creative work.

> It's an interesting structure...

I think that's the question. I'm very much used to reading "A machine-readable medium, comprising..." I'm curious what bits are unique to COVID-19, and what bits are generally protecting the idea of using a carrier to send a specific protein. In this case, is it the "S" protein phrasing that protects the specific embodiment of COVID19's spike?

Re: Moderna mRNA sequence released to GitHub [pdf]

#214

Post by issamehh »

mrfusion wrote: post #207
mlyle wrote: post #202

Earlier quoted context omitted.

> I have a "I'm sure that means something to somebody" feeling. Break it down! It's not so bad: > A composition A bunch of stuff > a messenger ribonucleic acid (mRNA) mRNA are cellular instructions on how to make proteins that are read by ribosomes that make those proteins as they read along. > an open reading frame This is something that starts with a "start codon" and ends with an "ending codon" and encodes valid i…

Why haven’t viruses or bacteria evolved to use a lipid nano particle to evade the immune system? Seems like a big security flaw in our cells?

Don't give them any good ideas

Re: Moderna mRNA sequence released to GitHub [pdf]

#215

Post by schoen »

mrfusion wrote: post #207
mlyle wrote: post #202

Earlier quoted context omitted.

> I have a "I'm sure that means something to somebody" feeling. Break it down! It's not so bad: > A composition A bunch of stuff > a messenger ribonucleic acid (mRNA) mRNA are cellular instructions on how to make proteins that are read by ribosomes that make those proteins as they read along. > an open reading frame This is something that starts with a "start codon" and ends with an "ending codon" and encodes valid i…

Why haven’t viruses or bacteria evolved to use a lipid nano particle to evade the immune system? Seems like a big security flaw in our cells?

I remember someone coming up with a song to encourage people to wash their hands more thoroughly much earlier in this pandemic.

https://twitter.com/vesselofspirit/status/123748864242514739...

According to the song lyric, "novel coronavirus / has a lipid outer shell". So it seems like some viruses have taken advantage of this.

Re: Moderna mRNA sequence released to GitHub [pdf]

#216

Post by akkawwakka »

ibraheemdev wrote: post #187

Is this all another medical company needs to start manufacturing and selling the vaccine themselves? Or is this sequence licensed/proprietary in some way?

No. The RNA still needs to be fit in a lipid nanoparticle which is Moderna and BioNTech’s secret sauce.

Re: Moderna mRNA sequence released to GitHub [pdf]

#217

Post by ineedasername »

airhead969 wrote: post #67
andrewcl wrote: post #42

Cool, but it's the lipid delivery system that is the secret sauce. This is equivalent to giving the source code without a compiler to build it.

Wouldn't the "compiler" be the bioreactor used to mass-produce it and the "installer" be the lipid encapsulation? :)

Maybe the booster shot can be done with a simple apt-get update.

Re: Moderna mRNA sequence released to GitHub [pdf]

#218

Post by wombatpm »

lettergram wrote: post #45
drtz wrote: post #31

I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears_. I get the feeling that this is something I have a better chance of understanding than the average SaaS Terms and Conditions. I expected to have to scroll through pages upon pages of indecipherable text. Instead it's no bigger than a large paragraph of text, and I can easily fit it on my screen.

It really is that “simple.” Getting it designed and building it is more difficult. At its core, it’s a piece of mRNA that creates a protein. That code gets transcribed into a protein (often those are relatively short). That protein then triggers your bodies immune response, which trains it to attack covid19. Inject this mRNA into a cell and it’ll create the protein. Anything can be injected at this point once the mec…

Which makes me wonder. Could you place the entire virus genome in these liposomes and get them to hijack the machinery to make an entire virus? Like plasmid but for viral structures?

Re: Moderna mRNA sequence released to GitHub [pdf]

#220

Post by Duller-Finite »

subroutine wrote: post #160
andrewcl wrote: post #42

Cool, but it's the lipid delivery system that is the secret sauce. This is equivalent to giving the source code without a compiler to build it.

Meh, they probably just used lipofectamine (which has been around since the 90s) or something very similar. https://en.wikipedia.org/wiki/Lipofectamine https://www.thermofisher.com/us/en/home/brands/product-brand...

lipofectamine is used for in vitro transfection, not in vivo gene delivery. The vaccines use lipid nanoparticles rather than liposomes
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