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Age Reduction Breakthrough?

joshmitteldorf.scienceblog.com

211–220 of 426 posts

Re: Age Reduction Breakthrough?

#211
post #14
post #7

Do we really want to live in a world where the billionaires live forever?

I don't mind them living forever. Why should I care?

Take a look at Altered Carbon on Netflix, or other dystopian fiction featuring vastly extended lifespans for a few privileged individuals. Even Ad Vitam (also on Netflix), where the treatment is widely available, is pretty dystopian.

We may find that vastly extended human lifespan is a case of "be careful what you wish for, because you just might get it."

Re: Age Reduction Breakthrough?

#212
post #70

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

Based on your comment, you will likely enjoy "The Boat of a Million Years", by Poul Anderson [0]. Needless to say, it's science fiction.

It's about a very small number of people who are immortal, in the sense they stop ageing at 25 (iirc). They can be killed like anyone else, but smaller damages do heal faster. Also, they never get sick. Some are thousands of years old, some less. Some smart, some not so much. How they handle their immortality is very interesting though. I won't spoil it for you though.

[0]: https://en.wikipedia.org/wiki/The_Boat_of_a_Million_Years

Re: Age Reduction Breakthrough?

#213
Improving longevity is what the people at https://www.lifespan.io/ have been trying to do for ages. The research is being done, there are tons of new promising things - with the catch that they are experimental / not tested on humans.

Before you get too excited and wonder where you can buy these magic pills, remember that there are things you can do right now to improve both your longevity and your quality of life: 1) sleep properly 2) eat properly 3) exercise 4) reduce stress

That being said I think that the next 20-30 years are going to be really interesting in this space, and if we indeed have any sort of proven breakthrough this will force us to rethink how we think about our society and our mortality.

Re: Age Reduction Breakthrough?

#214
post #25

Was told by my wife years ago that there is a Hong Kong tycoon who has been doing this for years. Supposedly hires young people to do nothing but to stay healthy and then has transfusions of their blood. Just checked and he is still alive at 91. But this echoes vampire. This reminds me of plasma treatment for covid-19 which is actually proven. Perhaps someone will create a market for that.

https://www.imdb.com/title/tt0065303/

Re: Age Reduction Breakthrough?

#215
post #70

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

I think the variation in “visual age” is too large for “look like 25 by the time we reach 40” to be an outlier.

Excessive smoking and UV light exposure can easily make a 25-year old look older than a healthy 50-year old who exercises regularly, uses sunscreen when they go out in the sun, and didn’t get scars from accidents.

Re: Age Reduction Breakthrough?

#216
post #95

Earlier quoted context omitted.

What's wrong with not wanting to die?

Being dead is basically the equivalent experience as not having been born. I'm not terribly upset about all the things I missed before 1977 AD. Not sure why I should be too worried about what I'll miss when I'm gone.

This line of reasoning has always felt incredibly bleak. There's an implied lack of preference for continued experience which can be repurposed to regard suicide indifferently.

It's difficult to take a consistent position that holds both "I don't want to die early" and "I don't care if I die". It requires an arbitrary judgment on what constitutes 'enough' life.

Imagine a pill that gives you 10 years of good health and freedom from aging. No tricks, no evil genies, no monkey paws. It's completely free and universally available. It's not a one time offer. You can change your mind later as many times as you want. How many people would actually refuse that pill and choose to die at a 'natural' time?

Based on how much we spend on medicine, I'd guess very few, and that seems like a clear preference for being alive.

Re: Age Reduction Breakthrough?

#217
post #70

Since it seems like the upshot of all of this is that Katcher is claiming to have discovered a set of signalling molecules which, when injected, rejuvenate tissue and presumably lengthen life, it runs into one of the most fundamental objections that can be leveled at theory of aging (or cure thereof): of the billions of humans that have existed, how is it that none of them have possessed a mutation which (in this cas…

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

That's pretty much the plot of the story The Man From Earth written by Jerome Bixby. He also wrote a similar story for the original Star Trek series.

The Man From Earth and its sequel are on Amazon Prime Video.

edit: I should have did a ctrl+f man from earth

It's a great show everyone seems to have seen it. I never knew about it until I saw it in my Amazon Prime Video suggestions.

Re: Age Reduction Breakthrough?

#218
Are there no people who have to receive regular blood donations? Would you not notice such an effect in these people? I guess the donors are probably not all younger than the receiver but on average this is probably true. Does anyone know of a subpopulation that might qualify?

Re: Age Reduction Breakthrough?

#219

Improving longevity is what the people at https://www.lifespan.io/ have been trying to do for ages. The research is being done, there are tons of new promising things - with the catch that they are experimental / not tested on humans. Before you get too excited and wonder where you can buy these magic pills, remember that there are things you can do right now to improve both your longevity and your quality of life: 1…

I believe the most impactful thing you can do is drastically reduce caloric intake - like by 50%.

Experiments have show large increases in lifespan, across mammals.

Re: Age Reduction Breakthrough?

#220
post #94
post #70

Earlier quoted context omitted.

At risk of sounding absolutely insane: There's probably no way to prove that this hasn't happened. Anyone who realizes they're not aging normally would likely have taken on a new identity elsewhere for fear of: 1. being burned at the stake 2. being trialed in repeated experiments 3. being deified, and then subsequently being burned at the stake. --- I realize my comment sounds like a joke, but I'm entirely serious. I…

One of my most favorite sci-fi movies explores this idea [0]. It's very intriguing and quite entertaining. [0] https://en.wikipedia.org/wiki/The_Man_from_Earth

I just commented before seeing your mention of it.

Although I didn't realize until I commented that Jerome Bixby the author of The Man From Earth was also a Star Trek writer.

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