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CRISPR eliminates HIV-1 infection in live animals

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211–220 of 267 posts

Re: CRISPR eliminates HIV-1 infection in live animals

#211

Working in genetics, which was putting aside nanophysics, began as necessity coming in it's most immediate form; given a new name in the form of an acronym and a clock marking the period I would certainly be on the door of, a second value on the clock was a 3 month window represented in how long it would take to reach the other side of the door, that door we all go through at some point. It was 2011, age 30, and woul…

This is a very confusing and eerie post. It sets off "scammer" red flags as well. The account is 303 days old, and this its only post.

Appears to be someone well grounded in scientific vocabulary, who has End Stage Renal disease, speaking in not precise names, dates but testing the waters, hoping to find that special something or someone to read between the lines, connect the dots, put two and two together, and investigate whether the methodologies and/or procedures hinted at but not disclosed, warrant an NDA which can add a few months or productive years to this person's life, a bit of happiness, and worthwhile endeavor to the sufferings of his/her fellow man. On the other hand, I could be his henchman in some foreign land putting the final sayso into his/her scheme to bankrupt countless widows and elderly persons of their life savings... not to dissuade the post I am replying to, just urging an 'it' to develop more rationally into a person behind the introduction, just in case a molecule or particple, scientifically and/or grammatically speaking, of course, displays a rational and well-thought out reason to break in an abbreviated form, the silence the person has endured for such a length of time. [ My two cents, but I try to be a person who encourages discourse of not small matters in the outlier venues, vs wholesale repetition of not detailed fad and foodie that enveloped me, for a period of time, in a worrisome freedom to chase such a fad upon a false supposition and sidelines these prose paragraphs from relevancies and on-topic treatise, vs the hindsight that hopefully posts once in a while whatever it may. .................. Please remit this post to the bottom of the page, in a unbolded font, with requisite speed and equally unmet response, as it is meant to be a footnote to the long post above, not a point of discussion, within the thread, and unwittingly contributes nothing to the discussion, as making footnotes is a hobby of mine, without which I should never write upon these pages of intelligence which so enliven my predawn times when I appreciate so much the discourse of those more due to embrace the rarities of romance and partisanship than that of I and the few others with which I share a common compensatory goal. ..................................... Thanks! ......................................

Re: CRISPR eliminates HIV-1 infection in live animals

#212
post #205

Earlier quoted context omitted.

> academic/political/military/banking/corporate alignment against fundamental morals "fundamental morals"? What are those and where the hell do you get them from? > The reason people probably have strong convictions about right or wrong is most likely because of nature, not despite it. Groups that had this genetic trait built tribes, societies that had greater success in the long term. Actually, couldn't agree more.…

Re fundamental morals: I would wager >95% of people agree on these. I've never met someone who didn't have an understanding of fundamental morals, except for a few people whom I consider to be a psychopaths. I really would bet that most of us dont need an education to know that killing children for pleasure is wrong and disgusting. However, we might be split on whether spanking your children as punoshment is wrong. I…

> I really would bet that most of us dont need an education to know that killing children for pleasure is wrong and disgusting.

Can I remind you that abortion is legal and funded by the state in most of the first world?

It's not that I have a personal opinion on the matter (I find it too complex to develop a definite opinion), but it does come pretty close to what you're describing.

Re: CRISPR eliminates HIV-1 infection in live animals

#213

Earlier quoted context omitted.

This is a very confusing and eerie post. It sets off "scammer" red flags as well. The account is 303 days old, and this its only post.

Appears to be someone well grounded in scientific vocabulary, who has End Stage Renal disease, speaking in not precise names, dates but testing the waters, hoping to find that special something or someone to read between the lines, connect the dots, put two and two together, and investigate whether the methodologies and/or procedures hinted at but not disclosed, warrant an NDA which can add a few months or productive…

I get the impression that the p and ggp comments are part of a misguided experiment in automatic text generation.

Re: CRISPR eliminates HIV-1 infection in live animals

#214

Genomic responses in animal models do not mimic themselves in humans. Great example is thalidiomide. https://www.quora.com/What-are-examples-of-drugs-that-showed... https://walkerma.wordpress.com/2007/04/27/animal-models/ I advise extreme caution and context on hyping this. Derek Lowe wrote a great post on this a few years ago that I still reference whenever I see HIV animal claims. http://blogs.sciencemag.org/pipeli…

You post the classic cautionary comment but reviewing your sources, none of them at all seem relevant:

"Genomic responses in animal models do not mimic themselves in humans" - source? Thalidomide is just a random example of a traditional non-genetic treatment. Specifically the CRISPR mechanism clearly has no precedent of failure, as the Chinese only recently began human trials. There's no precedent of success, but there seems to be no reason to believe it won't work, since it works fine in vivo in other mammals.

And the Lowe link you provided is complaining about in vitro testing; this was in vivo. As far as I can tell, it's exactly what he suggests needs to be done before there's any hype.

If your point is simply that many things have been tried and failed in the past, sure, that's common knowledge. But CRISPR is not a similar approach, there is very little precedent, so IMO optimism is just as warranted as "extreme caution".

Re: CRISPR eliminates HIV-1 infection in live animals

#215

Earlier quoted context omitted.

Given billionaires running their own space programs it makes me wonder why there aren't more billionaires running biologic research companies. Between life extension and immunity to (or protection from) really pathological conditions it seems like their interests would be aligned with folks like this.

Take a look at the Howard Hughes Medical Institute, which uses a well-known billionaire's money for funding basic research in biology and neuroscience.

You mean the tax dodge that only started doing research when the government started investigating?

Re: CRISPR eliminates HIV-1 infection in live animals

#216
post #141

Earlier quoted context omitted.

AIDs, cancer, etc., is great, but what about male pattern baldness?

In all seriousness, what could happen for trans individuals? What would be the actual effect of replacing all cells' XY's with XX's?

Female patient transitions to male, then gets male pattern baldness. /s

Re: CRISPR eliminates HIV-1 infection in live animals

#217
post #205

Earlier quoted context omitted.

Re fundamental morals: I would wager >95% of people agree on these. I've never met someone who didn't have an understanding of fundamental morals, except for a few people whom I consider to be a psychopaths. I really would bet that most of us dont need an education to know that killing children for pleasure is wrong and disgusting. However, we might be split on whether spanking your children as punoshment is wrong. I…

> I really would bet that most of us dont need an education to know that killing children for pleasure is wrong and disgusting. Can I remind you that abortion is legal and funded by the state in most of the first world? It's not that I have a personal opinion on the matter (I find it too complex to develop a definite opinion), but it does come pretty close to what you're describing.

It's not. An egg moments After fertilization experiencing suffering requires quite a bit of inagination, while we all can agree a child can suffer. Where we draw the line between that is obviously somewhat up for debate (and no one in their right mind is saying we should kill born babies for pleasure).

Re: CRISPR eliminates HIV-1 infection in live animals

#218

Earlier quoted context omitted.

This is fascinating. How in the world does the body "raise antibodies" that are effective against arbitrary proteins it hasn't seen before? How does this get "remembered" and how does the memory get communicated through the body? If there's an ELI5 (or, ELI-college-101) I'd be interested to read it.

Very over-simplified: You have a random library of many billions of cells each making a single unique antibody that was created via random combinatorial genetic shuffling early on. The ones that accidentally bind to your own natural proteins are filtered out by killing them before they leave the bone marrow, so the circulating cells remaining form a library that could only bind -foreign- proteins. When one of these f…

Is there concern that those long-lived antibody clones become pathological themselves?

Re: CRISPR eliminates HIV-1 infection in live animals

#219

Earlier quoted context omitted.

Not just billionaires. One of my besties is directly funding early stage Lyme Disease research. Directly to the lab and researchers. Bypassing orgs, foundations, panels, etc. He has a vested interest in accelerating the process and has already benefitted from their findings. This direct funding model will become a significant strategy, as it becomes ever easier to find and connect interested parties.

I'm glad your friend is able to do that. It makes sense to directly fund the research when you directly benefit from their findings. I'm curious about the direct funding process. Does the lab approach him saying "we need money for this equipment"? Or is it like an ongoing regular donations sort of thing?

My friend found the researches himself, built relationships. He's done both one-time donations and ongoing commitments. Pretty much whatever he can help with.

Re: CRISPR eliminates HIV-1 infection in live animals

#220
post #217

Earlier quoted context omitted.

> I really would bet that most of us dont need an education to know that killing children for pleasure is wrong and disgusting. Can I remind you that abortion is legal and funded by the state in most of the first world? It's not that I have a personal opinion on the matter (I find it too complex to develop a definite opinion), but it does come pretty close to what you're describing.

It's not. An egg moments After fertilization experiencing suffering requires quite a bit of inagination, while we all can agree a child can suffer. Where we draw the line between that is obviously somewhat up for debate (and no one in their right mind is saying we should kill born babies for pleasure).

You seem to be using subjective experiences and the ability to experience them as base for your moral system. Is it the case? Why?
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