Does anyone actually have any problems with Thunderbird? I feel like it is "done" software. It works, perfectly, for all my needs. It's fast. It has great UI. It lets me read and write email.
It doesn't perform that well with some of my folders which are >300,000 messages. (protip don't subscribe to LKML)
Careful configuration of the sending/reply address should let you reply to the mailing list by email as normal, or there may be a way using NNTP -- the documentation on the GMane website is missing, as they're rewriting the service.
[1] http://dir.gmane.org/gmane.linux.kernel
[2] nntp://news.gmane.org/gmane.linux.kernel