201–210 of 431 posts
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Semaglutide is effectively $99/month in the US. Not from shady sources.
Do you mean with health insurance? Novo Nordisk still lists it at $1000+ on their website: https://www.novopricing.com/ozempic.html
It seems we are treating Peptides like drugs here. It's my opinion that amino acids regardless of how they are chained do not belong under and stricter regulation than food given I eat peptides every day from my food. Then again I do not believe in the concept of prescription drugs. Everything with a NDC code should be at the grocery store and I should be able to stock up on it without permission especially given how…
> It seems we are treating Peptides like drugs here That’s exactly what some biological drugs are too - peptides! And peptides are just short chains of amino acids. Almost all the other biological drugs are just longer chains of amino acids - antibodies, enzymes, antigens, some hormones, and others. Derek is right that the safety risks are exponentially higher when you inject peptides - you basically skip a bunch of…
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Do you have a link to those data showing GLP-1 agonists are ineffective?
I emphasize it's like the drug disulfiram: Very effective as long as patients take the full dose, but the lack of real-world efficacy stems from the difficulty in adhering to the treatment. This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years. https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
Do you have a source for this "lack of real-world efficacy"?
> This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years
"With a with a median on-treatment weight change of −2.9%" [1]. Of those who discontinued and experienced "weight gain since discontinuation," they were "associated with an increased likelihood of GLP-1 RA reinitiation."
I'm genuinely struggling to see how this source shows real world inefficacy. In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to.
Out of curiosity, what sources lead you to believe this?
> it's like the drug disulfiram
Have clinicians made this connection?
[1] https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
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Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…
Im sorry for your quality of life problems but calling doctors bad at statistics and then giving anecdotal evidence as proof has to start ringing some logical bells right? You dont even have to take our word. Use an LLM as judge. Paste your comment into chatgpt and see what it says.
Doctors, at least 15 years ago, were definitely bad at statistics.
They were not required to take a statistics course at all. Most programs would require Algebra and Calculus as part of their science reqs.
Some would maybe take one basic research course, and they would then become obsessed with p values of 0.05.
They did not have a basic understanding of how to interpret research unless they were an auto didactic and went out of their way to improve. It's something my director (a doctor and software engineer), and the Dean complained about relentlessly.
I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…
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I'm glad we have GLP-1, and I don't think there are really major side effects. But they are ineffective outside clinical trial setting for treating obesity. It seems to be like treating alcoholism with disulfiram: it's a miracle in clinical trials but in the real world the patients just lower the doses or discontinue treatment after 1-2 years and go back to their old habits.
> they are ineffective outside clinical trial setting for treating obesity This is totally false. I know a number of people who took GLP-1 to treat their obesity and then stopped and have stayed not obese.
> In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to. Out of curiosity, what sources lead you to believe this?
Anecdotes like this are interesting but in medicine they are not sufficient to make factual statements about drugs. In meta-analyses there is weight regain which is steeper as more weight is lost during treatment [1].
The weight regain seems to be rather slow, it can take years until the baseline weight is reached.
Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…
> Peptides are a revolution and you don't need to know how they work to know that they work Perhaps. But knowing the mechanism of how they work sure seems fundamental to ensuring that they are safe to use.
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It has a certain logic to it, and I think US tipping culture basically follows the same rules. Even if you almost always end up paying the bill + 20% tip, Americans like the idea that they could not pay the tip if the service was bad. The appearance of free action is appealing and preferable to being forced to pay the extra amount, even if you almost always pay the amount willingly anyway.