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GLP-1 drugs linked to lower death rates in colon cancer patients

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#201

Earlier quoted context omitted.

This isn't "I could use my money to acquire food for the poor." It's "I'm going to prevent anyone else from selling food, and that will let me charge 100x as much for food."

And yet, if the system wasn't set up this way it's likely that these medicines would never have been developed in the first place. If we take away investor returns now, why would they ever pursue developing similarly effective drugs in the future?

On the contrary, profit motive and immaterial rights slow down innovation and the spread of new technologies.

This is why states are the main producers of knowledge and funding most of the interesting research.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#202
post #64

Earlier quoted context omitted.

Kind of weird to assume other people think it's fine to exchange human lives for money. Is it ethical for me to pay someone to murder you? Does it matter if it costs me a large amount of money or not?

Why do we pay doctors? Are they evil if they refuse to go to work for free?

Please explain the relevance of this supposed analogy. How is a doctor withholding their labour restricting the behaviour of anyone else?

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#203

Earlier quoted context omitted.

Compounded GLP-1s are still floating around in the US

I compound tirz with glycine and B12. I honestly think these are miracle drugs. I’ve never been extremely overweight but I hit a point where I had 30 pounds to lose, despite my height, and I can’t deal with the hunger amidst all my other life stresses.

In a similar boat (overweight, borderline obese - slightly elevated cholesterol - high stress) and my doc has recommended I look into GLP-1s and maybe ask my insurance which types they do and don't cover.

Worst comes to worst I could go compounding for about $200/mo from what I've seen.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#204

If you eat less your stomach/whole body gets time to relax and repair?

Beware of intuitive conclusions. (AKA: Truthiness) It's easy to believe something because it sounds true but still be completely wrong.

https://www.merriam-webster.com/dictionary/truthiness

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#205

I am 100% a layman here so apologies if this is a stupid analysis. But I have read that fasting can improve odds and improve side effects during chemo. Would GLP-1 stabilising blood sugar be having the same effect?

I would hesitate to draw a conclusion without more evidence. One way or another.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#206

Earlier quoted context omitted.

An interesting FYI is a comment made by Peter Attia on his podcast. He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss. They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects. It seems like GLP1, even in skinny patients (…

It shouldn't make any difference where you pin it, it's systemic it just has to be administered subcutaneously because it's a peptide and it isn't orally active. Don't listen to these YouTubers about health and fitness, most of them are clueless

Peter Attia is a graduate of Stanford medical school and spent 5 years in surgical residency at Johns Hopkins, and his podcast is largely using his expertise to give context to recently published research. His opinions are always pretty directly linked to peer reviewed research and he updates his stances as new research becomes available and explains why (eg, his shift away from fasting).

He really shouldn't be lumped in with the general "health and fitness Youtubers".

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#207

Earlier quoted context omitted.

This isn't "I could use my money to acquire food for the poor." It's "I'm going to prevent anyone else from selling food, and that will let me charge 100x as much for food."

And yet, if the system wasn't set up this way it's likely that these medicines would never have been developed in the first place. If we take away investor returns now, why would they ever pursue developing similarly effective drugs in the future?

Good point, maybe researching drugs and treatments shouldn't be done primarily by for-profit companies, and governments should take this on themselves.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#208
post #202

Earlier quoted context omitted.

Why do we pay doctors? Are they evil if they refuse to go to work for free?

Please explain the relevance of this supposed analogy. How is a doctor withholding their labour restricting the behaviour of anyone else?

People spend their time and resources developing drugs because they know that the patent system provides them an opportunity to earn a return. If drug patents weren’t enforced, GLP-1 would have never been developed. We could rug-pull the particular companies who own GLP-1 patents by removing patent protection after the fact, that would work to improve access to these particular drugs. But then the next lifesaving drugs won’t be developed, because there will be no prospect for a return.

Similar to how doctors save lives and earn a paycheck. We could stop paying doctors, enslave them to work 18 hours 7 days a week so more people get medical care. On top of being obviously evil and wrong, it would also be counterproductive, because then nobody would become a doctor.

Put simply, drugs cost money because money is how we direct resources as a society. There is not a cheat code where we can simply make the drugs free and still expect resources to magically appear and manifest the drugs. The drugs exist because we pay for them.

I share the feeling that it’s awful that people are blocked from access to these lifesaving drugs by money. But simply eliminating patent protection is not a workable solution. It needs to be accompanied by a replacement mechanism to incentivize drug development. For example, government gives out massive prizes to the drug developer but there is no patent protection.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#209
post #31
post #3

Earlier quoted context omitted.

Haven't you been reading Hackernews for the past 10 years? Sugar has been implicated in pretty much every major late-life disease, and the closest thing to a cure before GLP-1 agonists was fasting.

That's such a lazy and unimaginative take that basically skips 99.999% of human history during which sugar wasn't a problem at all.

Refined sugar hasn't been a problem for 99.999% of human history because it hasn't existed for 99.999% of human history.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#210
post #31

Earlier quoted context omitted.

That's such a lazy and unimaginative take that basically skips 99.999% of human history during which sugar wasn't a problem at all.

Refined sugar hasn't been a problem for 99.999% of human history because it hasn't existed for 99.999% of human history.

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