Live data from Hacker News

Ozempic shows anti-aging effects in trial

trial.medpath.com

201–210 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#201

Earlier quoted context omitted.

It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. Like, I figured we were just never going to solve it, given the two possibilities were "radically re-engineer US culture such that moving to the US doesn't make previously-skinny people fatter" (with other countries heading the same direction as us needing to make similar moves, one supposes) or "find…

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

> some weird injection

What’s weird about it? Is insulin some weird injection? What about epinephrine?

Re: Ozempic shows anti-aging effects in trial

#202

Earlier quoted context omitted.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

[flagged]

[flagged]

Re: Ozempic shows anti-aging effects in trial

#203
post #162

Earlier quoted context omitted.

Inaccurate in my opinion. Let's say you eat 2500 calories a day usually. But you want to lose weight so you reduce it to 1800. Except your calories are from pop tarts. If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter. If you ate 1800 calories of pop tarts once a day in 1 hour, you might maintain weight or loose a little. Maybe. If you h…

> If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter. This is thermodynamically impossible unless your daily calorie use is less then 1800 calories.

It is only thermodynamically impossible if you assume 100% efficiency in energy extraction from food, but in practice we only extract a very small amount of energy from matter. Thermodynamically you could extract ~10^12 kcal from a Pop Tart if you converted its mass into energy.

Not that I agree that for a human metabolism meal timing makes much of a difference in energy extraction, but it wouldn't be thermodynamically impossible.

Re: Ozempic shows anti-aging effects in trial

#204

Earlier quoted context omitted.

Run a study of your approach and show good results over a cohort for 2+ years and you'll make an entire sub-field of medical scientists very happy. [EDIT] It's not that your approach can't work, it's that if (for example) people had as hard a time following the directions for condoms as they do following diet & workout plans, we'd never allow condoms to be sold as contraceptives, they'd not even be close to being OK…

[flagged]

You’re a fool. “Pull out” does not protect against pregnancy or STDs. Pre-ejaculate can have viable sperm in it.

Re: Ozempic shows anti-aging effects in trial

#205

Earlier quoted context omitted.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

[flagged]

I find that almost all doctors give useless advice. On multiple occasions I've been advised that there was nothing wrong but they can run a scan "if I insist" and then bam, the exact problem I expected shows up clear as day.

They're morons for the most part.

Re: Ozempic shows anti-aging effects in trial

#206
post #203
post #162

Earlier quoted context omitted.

> If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter. This is thermodynamically impossible unless your daily calorie use is less then 1800 calories.

It is only thermodynamically impossible if you assume 100% efficiency in energy extraction from food, but in practice we only extract a very small amount of energy from matter. Thermodynamically you could extract ~10^12 kcal from a Pop Tart if you converted its mass into energy. Not that I agree that for a human metabolism meal timing makes much of a difference in energy extraction, but it wouldn't be thermodynamical…

It's insane to me that people keep talking about the energy in part. Forget that.

Realize that WHAT you put in can change what energy out is.

If I gave you 1800 calories of vodka at 8am, would your use the same amount of energy during the day, and even make it to your 7pm gym? No.

Ok, well sugar isnt exactly the same obviously, but it can also affect what you do that day, how your body acts, your brain even.

Your energy out gets totally messed with after you have tons of alcohol for obvious reasons. Something similar happens on sugar/spiked insulin levels. Can you willpower through it and increase your energy out by running til you drop dead and lose weight? Sure. But it's not easy.

What's way easier is not having the insulin spike in the first place.

Re: Ozempic shows anti-aging effects in trial

#207
post #88

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

[flagged]

I don't understand why comments about pharmaceutical companies and their incentives are accepted here, but if you mention the same in the context of vaccines, you're labeled a conspiracy nut.

Re: Ozempic shows anti-aging effects in trial

#208

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

every time in recorded human history when there's be a panacea or cure-all it's generally been snake-oil. There are a lot of side effects, of this type of medicine - many which were not really prevalent when it was prescribed on-label.

Antibiotics?

Re: Ozempic shows anti-aging effects in trial

#209

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

True enough, but many studies show that calorie restriction reduces effects of aging

Re: Ozempic shows anti-aging effects in trial

#210

Earlier quoted context omitted.

I'm curious if this affects smartphone usage. E.g., "compulsive" feed-checking and doom scrolling.

I wonder how it compares to Adderall.

I have an Adderall prescription, although I rarely use it. Adderall lets me focus on things longer, with distractions staying in the background. If anything, Adderall makes me too focused on a task.

If I were doom scrolling when Adderall kicked in, the risk is I'd continue doing it for hours.

Post reply on HN