While it may be tempting to go "mini" and NVMe, for a normal use case I think this is hardly cost effective. You give up so much by using an all in mini device... No Upgrades, no ECC, harder cooling, less I/O. I have had a Proxmox Server with a used Fujitsu D3417 and 64gb ecc for roughly 5 years now, paid 350 bucks for the whole thing and upgraded the storage once from 1tb to 2tb. It draws 12-14W in normal day use an…
Another thing is that unless you have a very specific need for SSDs (such as heavily random access focused workloads, very tight space constraints, or working in a bumpy environment), mechanical hard drives are still way more cost effective for storing lots of data than NVMe. You can get a manufacturer refurbished 12TB hard drive with a multi-year warranty for ~$120, while even an 8TB NVMe drive goes for at least $50…
And these prices are getting low enough, especially with this NUC-based solutions, to actually be price competitive with the low tiers of drive & dropbox while also being something you actually own and control. Dropbox still charges $120/yr for the entry level plan of just 2TB after all. 3x WD Blue NVMEs + an N150 and you're at break-even in 3 years or less