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Taurine deficiency as a driver of aging

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Re: Taurine deficiency as a driver of aging

#201

Post by dluan »

throwaway888abc wrote: post #37
redkinght99 wrote: post #8

Taurine? I've been jacking myself full of that since Middle School! Thanks RedBull! Jokes aside, This feels like one of "Wine is Good for you " In moderation and other fine point details. Not buying it.

Can't stop laughing. The day after is terrible, but with the aging factor relevated - here is the recipe of favorite anti-aging cocktail Jäger Bomb Ingredients 1 1/2 ounces Jägermeister Liqueur 1/2 (8.4-ounce) can Red Bull energy drink https://www.thespruceeats.com/jager-bomb-recipe-759713

jaeger has a history as a traditional alpine bitter of serving some sort of medicinal purpose. like chartreuse or absinthe, lots of the herbal ingredients inside sometimes helped soothe upset tummies, or in the case of wormwood, expel parasites and worms.

Re: Taurine deficiency as a driver of aging

#202

Post by AtlasBarfed »

robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

WHy does it have Taurine? I honestly don't know why any of the non-caffiene non-b vitamin ingredients are in "energy drinks" like Taurine.

Re: Taurine deficiency as a driver of aging

#203

Post by vhcr »

throwaway2037 wrote: post #200
briHass wrote: post #192

Earlier quoted context omitted.

> That said, I'd absolutely recommend sugar over many other available sweeteners. I sure wouldn't. Many of the classic, non-nutritive sweeteners like sucralose have been tested more thoroughly than almost any substance we ingest. Even at heroic doses tens of thousands of times higher than what would be used normally, no significant health effects have been noted. In contrast, we have sucrose: a caloric carbohydrate t…

You seem knowledgeable about sucralose ("Splenda" in US commercial branding). Thank you to share. On Wiki, it says that sucralose is "genotoxic", but provides no further information. I read the genotoxic Wiki page -- sounds terrible. What am I missing? To be clear: This is not a scare post, rather "explain it to me like I am a 5 year old"! When I Google >, most of the results are untrustworthy, click-bait news source…

The genotoxic edit was added by an IP editor citing an in-vitro study, I wouldn't pay much attention to it, you can find higher quality references on the article, for example this one:

https://www.sciencedirect.com/science/article/pii/S027869151...

Re: Taurine deficiency as a driver of aging

#204

Post by seydor »

K0balt wrote: post #91
seydor wrote: post #84

Earlier quoted context omitted.

But if the organism lived longer it would keep pumping semiclones. And if organisms are basically huge self-sustaining feedback loops, why won't they keep sustaining ... forever until some pressure forces them to decay

Sexual reproduction, which increases fitness? So theoretically the offspring are more fit clone producers so competing with them is bad, M’kay?

But who invented fitness? Theoretically a self-sustaining chemical reaction can go on forever, and it is energetically less costly to search ways to sustain it even further rather than rebooting the whole organism from start. The invention of death must have happened before the beginning of evolution. Which reminds me that our quest for immortality is the end of it.

Re: Taurine deficiency as a driver of aging

#205

Post by AtlasBarfed »

giardini wrote: post #21

In the study mice were given 1000 mg taurine per kg body weight per day. In comparison a typical taurine supplement for humans is 1000 mg total . IOW they gave the mice a dose of taurine that, proportionally, i'd be unwilling to take.

1000 mg ... you mean a gram :-) ?

Re: Taurine deficiency as a driver of aging

#206

Post by mo_42 »

isk517 wrote: post #71
browningstreet wrote: post #45

Earlier quoted context omitted.

MSM media is always trying to convince people they can live longer if they stick with coffee, berries, dark chocolate and wine — as if those foods needed boosters. And if true I’m quite sure we’d have people out there living to 150…

You probably can live longer if you stick with coffee (black), berries (minus the food you put the berries on top of), dark chocolate (unsweetened), and wine (in strict moderation).

Instead of wine I'd go with resveratrol directly.

Re: Taurine deficiency as a driver of aging

#207

Post by spiderice »

throwaway2037 wrote: post #198
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

There is a comment much further down the page explaining how dosages don't translate across species like this. Apparently the human equivalent would be 6.48 grams per day.

Re: Taurine deficiency as a driver of aging

#208

Post by theNewMicrosoft »

pengaru wrote: post #146
isk517 wrote: post #71

Earlier quoted context omitted.

You probably can live longer if you stick with coffee (black), berries (minus the food you put the berries on top of), dark chocolate (unsweetened), and wine (in strict moderation).

Dark chocolate isn't exactly the safest food, even unsweetened: https://time.com/6243073/heavy-metals-dark-chocolate-food/

Add to that the high oxalate content in dark chocolate.

https://www.sciencedirect.com/science/article/abs/pii/S08891...

Re: Taurine deficiency as a driver of aging

#209

Post by jaggederest »

throwaway2037 wrote: post #198
robwwilliams wrote: post #133

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

Standard intake of taurine in most people is <200mg a day. That would be an astounding amount of taurine. Also, it's a little weird because humans can synthesize taurine, it's a major component of bile, so I'm unclear what mechanism could cause supplementation to have significant effects.

Re: Taurine deficiency as a driver of aging

#210

Post by DoreenMichele »

jaggederest wrote: post #209
throwaway2037 wrote: post #198

Earlier quoted context omitted.

By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…

Standard intake of taurine in most people is <200mg a day. That would be an astounding amount of taurine. Also, it's a little weird because humans can synthesize taurine, it's a major component of bile, so I'm unclear what mechanism could cause supplementation to have significant effects.

I know of a condition that seems to involve inadequate bile production. So hypothetically, it could help in that case.
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