Live data from Hacker News

What happened to the lab-leak hypothesis?

unherd.com

201–210 of 792 posts

Re: What happened to the lab-leak hypothesis?

#201
What I really want to know is "so what?" I mean, it would be great to learn about the origin and then take steps to reduce the chance of the same thing happening in the future.

But it appears most people just want to point the finger and that no change would result.

In fact one could imagine potential improvements for either case, some of which might be worth doing regardless of the actual origin.

Re: What happened to the lab-leak hypothesis?

#203
post #189

Earlier quoted context omitted.

Thank you for posting this. WHO-China report found that COVID almost certainly came out of China and the market is just the amplifying venue. It's the racist and xenophobic groups that are trying to incite hatred against China by spreading propaganda.

Hard to see lab-leak as intrinsically anti-China giving that it was NIH financing those GoF experiments which produced the coronavirus in Wuhan. That same story for example is pushed in Russia, who is making friends with China, as anti-American. So basically the story is interpreted as anti-something depending on your political orientation.

To be clear - the NIH never financed any GoF experiments in Wuhan. There was a proposal that was never funded, and even in that proposal, the GoF work would happen in Baric's North Carolina lab.

Re: What happened to the lab-leak hypothesis?

#204
The unfortunate fact is that the only plausible consequence of a public acceptance (by government officials) of the lab-leak hypothesis, is that funding for research into viruses would get a lot more restrictive. Maybe not less funding, but it would go to far fewer labs, which have the highest levels of containment.

The profession which knows enough to settle this question, thus has a massive conflict of interest. We cannot expect bankers to say that the response to the GFC should be to break up banks. We cannot expect generals after a war to say that they screwed up. We cannot expect intelligence agencies to say that they should have less power and more oversight. Scientists are human, they want to keep their job and not have to move to another city to do it.

What is actually going to happen, is nothing, until and unless a second lab leak kills a lot of people.

Re: What happened to the lab-leak hypothesis?

#205

For those with a bit more background in the sciences, there's an increasingly massive amount of evidence to support Zoonotic origin. Philipp Markolin has a good rundown: https://protagonistfuture.substack.com/p/natures-neglected-g... Most of the "evidence" for lab leak is just weird insinuation -- it's increasingly hard to pin down what the advocates for that position are even arguing (e.g. whether it's a natural vir…

I feel like Unherd's article is actually misstating things. For example, "no infected animal on sale in the market or elsewhere in China has been found..." In fact, Bloomberg reported: "Disease detectives arriving from Beijing on the first day of 2020 ordered environmental samples to be collected from drains and other surfaces at the market. Some 585 specimens were tested, of which 33 turned out to be positive for SA…

Yep. Ridley and Chan wrote their book when the lab leak idea was vaguely more plausible, but even then it really overstated the evidence. It's aged very poorly.

Re: What happened to the lab-leak hypothesis?

#206

For those with a bit more background in the sciences, there's an increasingly massive amount of evidence to support Zoonotic origin. Philipp Markolin has a good rundown: https://protagonistfuture.substack.com/p/natures-neglected-g... Most of the "evidence" for lab leak is just weird insinuation -- it's increasingly hard to pin down what the advocates for that position are even arguing (e.g. whether it's a natural vir…

> China is a bad actor and definitely contributed to the conspiracy madness around the virus by being so shut-down and performing such a half-assed investigation

It definitely seems that the default reaction of any authoritaian/police-state environment like mainland China is to clamp down on things and restrict information whether or not it's necessary.

One needs to only look at the many examples of various scandals/disasters that have gone very briefly viral on Chinese language social media before the censors get to them (often within 8-12 hours of the breaking news) before everything gets deleted.

Re: What happened to the lab-leak hypothesis?

#207
post #132
post #115

Earlier quoted context omitted.

I'm going to be blunt here. No one with medical training thought this wasn't airborne.

Funny then how for the first few months of the pandemic the emphasis and public guidance was on desinfecting hands and surfaces and endless debates about how if masks actually help.

No one competent has debated that masks help.

Re: What happened to the lab-leak hypothesis?

#208

For those with a bit more background in the sciences, there's an increasingly massive amount of evidence to support Zoonotic origin. Philipp Markolin has a good rundown: https://protagonistfuture.substack.com/p/natures-neglected-g... Most of the "evidence" for lab leak is just weird insinuation -- it's increasingly hard to pin down what the advocates for that position are even arguing (e.g. whether it's a natural vir…

No post body was provided.

Re: What happened to the lab-leak hypothesis?

#209
post #115

Earlier quoted context omitted.

I'm going to be blunt here. No one with medical training thought this wasn't airborne.

The communication at the beginning was that it was only spread through respiratory droplets, so therefore the combination of social distancing and cloth/surgical masks would be sufficient. Airborne/aerosol transmission was only acknowledged by the WHO and CDC in May of 2021, over a year after the pandemic was declared. And taking that long to acknowledge it makes me think it wasn't just a strategic lie to preserve th…

CDC updated its site in Oct 2020 to acknowledge airborne spread. There is still something of an argument in the scientific/medical community about what "airborne" means. A lot of folks lived through https://en.wikipedia.org/wiki/1976_Philadelphia_Legionnaires... which is scary because if there's just another infected person in the building, they can infect people far away!

and when the initial scientific articles about COVID air spreading (https://wwwnc.cdc.gov/eid/article/26/7/20-0764_article) came out, many policy makers were truly terrified of making announcements that would cause worldwide panic.

Re: What happened to the lab-leak hypothesis?

#210
post #185

Earlier quoted context omitted.

Before implying it's not correct, do the math yourself. Calculate the relative drift among natural sequences and see if the moderna sequence is an outlier. How many single point mutations would it take to get from a known sequence to the moderna one.

Do what math now? I spent 10 years as an academic doing bioinformatics, with deep expertise in BLAST (I helped demonstrate that BLAST E-values accurately represent homology). If you look, he shows some pages with resuults where the E-value is 282. Normally, an evalue should be 1e-2 or better (ideally 1e-6) before you start making ANY claims. I've seen hundreds of examples where a person did the math, convinced everyb…

But this is not a homology exercise with natural selection. I can show you where I did a blast search, panned for "select amino acid substitutions of interest" and from the library out popped out a more efficient enzyme.
Post reply on HN