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Vitamin D and Depression (2020)

ncbi.nlm.nih.gov

201–210 of 221 posts

Re: Vitamin D and Depression (2020)

#201
Too lazy to look it up in my notes now, but as far as I understand: 1) Vitamin D is low in people with all kinds of bad conditions, including depression but also heart issues/etc. 2) Supplementing vitamin D is usually not found to do anything to improve these conditions, or the effects are ambiguous, limited and minor.

Clearly there's a 3rd variable. For lack of better options I call it "sun magic".

Re: Vitamin D and Depression (2020)

#202

Earlier quoted context omitted.

> "I have perused the literature" ...and you are? > 5k IU is an average dose and will absolutely not cause harm. This is wildly irresponsible to post, and should be removed from HN.

>...and you are? Someone who is wholly uninterested in the credential theory of epistemology. Back to reddit with that, please. > This is wildly irresponsible to post, and should be removed from HN. You don't seem to know what the TUIL actually means. The tolerable upper intake level of a substance is not the actual safe upper limit, it just guarantees that a certain level is safe. In the case of vitamin D, the actua…

> Someone who is wholly uninterested in the credential theory of epistemology.

So nobody qualified to answer this question? That's what I expected. In medicine more so than in nearly any other field, qualified experts should be the only people to express opinions publicly, considering the potential negative outcomes.

You really shouldn't be giving medical advice on any website, Reddit or Hacker News. This is on the same level as anti-vaxx shit, I hope you realize.

This, more than Reddit, is a place where qualified people discuss topics. If you'd like to wildly speculate, that sounds more like what happens on Reddit.

Re: Vitamin D and Depression (2020)

#203
post #170

Earlier quoted context omitted.

> "I have perused the literature" ...and you are? > 5k IU is an average dose and will absolutely not cause harm. This is wildly irresponsible to post, and should be removed from HN.

Are you sure? 5k being a safe average dose seems to be corroborated across the internet and the abstracts of some papers I've seen.

And yet, not a single reputable journal will publish those papers, the medical community won't change the recommendations, and those studies go unreplicated.

It seems like there's an undereducated underground on the Internet that has the hubris to think they know more than the medical consensus, so what you're seeing are the effects of that hubris, nothing more.

Turns out Vitamin D is the anti-vaxx of computer nerds. Pretty hypocritical, but unsurprising.

Re: Vitamin D and Depression (2020)

#204

Earlier quoted context omitted.

I'm going to go ahead and trust Harvard Medicine over a single study that has since gone largely uncited, and was published in "Nutrients" which carries an h-index of 115 (Nature, for example, carries an h-index of 1226) [0][1]. [0] https://www.scimagojr.com/journalsearch.php?q=19700188323&ti... [1] https://www.scimagojr.com/journalsearch.php?q=21206&tip=sid&...

You should never judge an article by where it was published (some exceptions of course), only in the quality of the work. Impact factors are loosely a measurement of significance of the work, in terms of how broadly applicable they are to the fields of science. It is absolutely not a strict measure of the expected quality of the article. Also, for what it's worth, most of the articles referenced in the Harvard Medici…

And why should I trust you? You've given a decree, "Thou shalt not judge a paper based on where it was published!" and then don't give any reasons why that would be the case.

Also, I'm not qualified to judge a paper by its work quality, I need to rely on the experts in the field for that, and a decent proxy for that judgement is where a paper gets published, so by looking at where a paper was published, I am judging a paper by its quality.

Re: Vitamin D and Depression (2020)

#205

Earlier quoted context omitted.

I use 60,000 to 90,000 IU's per day and have been doing so for years. The most I have taken in a 24 hour period is 140,000 IU's. There is no way I could have started off at those levels however. It would have induced major hypercalcemia had I done that prior to mobilizing all the stored/misplaced calcium in my gut and vasculature. I am not suggesting anyone else do this. One must have a specific need when doing this.…

How much K2 are you taking?

100mcg for each initial 5000 IU's for the day but I stop at 800mcg of K2 MK-7 regardless. I sometimes also take K2 MK-4 in addition to that. I also get a small amount of K2 from eggs.

Re: Vitamin D and Depression (2020)

#206

Earlier quoted context omitted.

The actual RDA is not correct.

It is more correct than the research that shows otherwise.

If you skin produces dozens of thousands of IU while staying 20 minutes in the sun, and the RDA is not even a tenth of that, I'd rather wage the RDA is completely wrong and misplaced.

Re: Vitamin D and Depression (2020)

#207

Earlier quoted context omitted.

It is more correct than the research that shows otherwise.

If you skin produces dozens of thousands of IU while staying 20 minutes in the sun, and the RDA is not even a tenth of that, I'd rather wage the RDA is completely wrong and misplaced.

Your skin doesn't do that.

Re: Vitamin D and Depression (2020)

#208

Earlier quoted context omitted.

The American Heart Association recommends no more than 1500 milligrams of sodium per day. Because sodium is being added to packaged and processed foods, the average American was getting way more sodium than the recommended amount. And given the number of obese people and those with hypertension who are salt-sensitive, lots of people were getting way more sodium than was healthy for them.

I … have never in my life heard of salt contributing to obesity. I’ve struggled with being severely overweight. I’m medically monitored for hypertension, both because of my weight history and medication which should increase my blood pressure. I struggle now to keep weight on. Salt is not a factor.

> I struggle now to keep weight on.

What was the change you made?

Re: Vitamin D and Depression (2020)

#209
post #147

Earlier quoted context omitted.

Anecdata: I grew up in LA. I was always relatively healthy. Moved to NYC. Developed autoimmune disease by my 6th year in NYC. I often wonder if I would have developed the disease if I had stayed in LA.

people in the past would grab a small jar full of dirt from home and drink it whenever countering some ailment, I actually think that'd still work due to the recent researches on gut bacterial and it's influences on immune system and all...

There is actually real science behind this idea of drinking your home dirt (I'm not sure if its apocryphal or anecdotal). The reason many people experience stomach upset or constipation while on vacation is because their gut micribiome is unaccustomed to the new environment.

Re: Vitamin D and Depression (2020)

#210

Earlier quoted context omitted.

The American Heart Association recommends no more than 1500 milligrams of sodium per day. Because sodium is being added to packaged and processed foods, the average American was getting way more sodium than the recommended amount. And given the number of obese people and those with hypertension who are salt-sensitive, lots of people were getting way more sodium than was healthy for them.

I … have never in my life heard of salt contributing to obesity. I’ve struggled with being severely overweight. I’m medically monitored for hypertension, both because of my weight history and medication which should increase my blood pressure. I struggle now to keep weight on. Salt is not a factor.

At around 1h16m, Dr. Rick Johnson talks about how the human body on a high salt diet can convert glucose to fructose.

https://www.youtube.com/watch?v=LbSic4Oo8ME&t=4590s

If you're eating a high glucose/carb diet, the body will convert glucose to fructose. Enough fructose will switch your body from fat-burning to fat-storage mode => obesity.

Hypertension (high blood pressure) can be caused by high uric acid levels.

Foods high in fructose and purines (beer, anchovies) will increase uric acid.

I sound like a spokesperson for this video, but watch the video for how fructose (and high purine content food - beer, anchovies et al.) causes high uric acid -> high blood pressure and gout: https://www.youtube.com/watch?v=LbSic4Oo8ME

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