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Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

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Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#201

Post by therealcamino »

superbaconman wrote: post #14
runnerup wrote: post #8

Earlier quoted context omitted.

I'm hopeful that research into whatever "long covid" syndrome is/isn't leads to excellent new medical knowledge that applies to much more than just COVID edge-cases. I suddenly got similar symptoms since getting a nasty version of strep throat last October. Notably I had an elevated fever (>102F) for quite a few days straight. I've never had COVID but I did get the mRNA vaccines + booster. Since that fever, my heart…

Tell your doctor about your symptoms and then ask for an ECG. You want to know if you have an underlying heart condition. Depending on what you find, there may be options that will eliminate your arrhythmias.

I agree, if you think you are having arrhythmias you should see a cardiologist as the first step. Try to exhaust the well-known medical avenues before considering that your health problems are from an unknown cause. Strep infections in particular can have cardiac effects (rheumatic heart disease).

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#202

Post by allturtles »

jonathan-adly wrote: post #165
favorited wrote: post #123

Earlier quoted context omitted.

Right. PPIs are available without prescriptions in the US, and are considered very low risk medications.

Using PPIs for a short duration is safe, using PPIs chronically is not safe and the risks have to be weighted very carefully. It's by far the most intervened on medications by clinical pharmacists (usually discontinuing for inappropriate use)

Maybe. Here's a skeptical view: "Despite a large number of studies, the overall quality of evidence for adverse effects of long-term use of PPIs is low to very low." [0]

[0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463334/

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#203

Post by dpark »

edmcnulty101 wrote: post #190
dpark wrote: post #180

Earlier quoted context omitted.

So…you misspoke? I also find this a really odd line to draw. The fact that treating ICU patients with anticoagulants is standard does not automatically mean it’s useful for long COVID patients. If it turns out that it’s useful, awesome, but it’s not obvious a priori .

I didn't see them misspeak. They just clarified. Their follow up statement was right in line with their original. Pretty cool that they're ahead of the curve on this. Even if they didn't know about long covid officially, they followed the known science up to that point, and this is incompletely but interesting new data that's showing it's helping more than possibly known at the time.

They’re not ahead of the curve. This long COVID treatment experiment is new and they equated it with an entirely different treatment. Saying “we knew this 2 weeks in” is dismissive and absurd. Knowing that NIH recommends anticoagulants for acute hospitalized COVID is entirely different than knowing that anticoagulants are useful for treating long COVID.

If someone published a study that CTE resolves with a month of Tylenol supplementation, this would be huge news. The fact that acute concussion pain is treated with Tylenol in no way implies this result.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#204

Post by datameta »

randcraw wrote: post #160
JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

80 mg/day aspirin generally has been shown to be safe long term, though it does increase irritation of the stomach. Maybe taking it with food will help that. I would absolutely NOT do the same with ibuprofen or any other NSAID. All other NSAIDs but aspirin have been shown to reduce blood vessel elasticity after habitual use. Adopting any med for regular use is not something to take lightly. "Ibuprofen, aspirin, and C…

Just got off daily naproxen (aleve) after ~6-7 years. Sanctioned by my doctor but was an important milestone stop taking it all the time. I dont know where it lays on the spectrum of safety amongst other NSAIDs but I sure am glad to not need it all the time anymore.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#205

Post by jonathan-adly »

allturtles wrote: post #202
jonathan-adly wrote: post #165

Earlier quoted context omitted.

Using PPIs for a short duration is safe, using PPIs chronically is not safe and the risks have to be weighted very carefully. It's by far the most intervened on medications by clinical pharmacists (usually discontinuing for inappropriate use)

Maybe. Here's a skeptical view: "Despite a large number of studies, the overall quality of evidence for adverse effects of long-term use of PPIs is low to very low." [0] [0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463334/

10 years ago, as a young post-grad I spent a ridiculous amount of hours analyzing ALL the published peer-reviewed literature on the pros/cons of PPI prophylaxis for CVD patients and published my results in a peer reviewed article. I am literally the expert in that topic lol. Here is a nice paper[0] by Adly (me!), et al. I am biased, but I find it to be very comprehensive (and an excellent cure for insomnia!)

[0]: https://pubmed.ncbi.nlm.nih.gov/23386069/

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#206

Post by SketchySeaBeast »

swayvil wrote: post #199
SketchySeaBeast wrote: post #197

Earlier quoted context omitted.

I'm still confused, because I don't know how that connects to your question "Could covid not actually be just a disease?", because it clearly is as it's affecting people. If we assume that the cold is a disease so is COVID, by the same criteria. Is the cold not just a disease? If so, what is just a disease?

It's a pretty simple idea. I'm having doubts about this "confusion".

Fair enough. I think you're throwing a weird "disease" distinction and then moralizing angle into COVID which doesn't make any sense. We didn't just hit some sort of health critical mass for illness. COVID is its own beast and it's hurting a ton of people and implying it's people's fault for eating junk is bizarre.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#207

Post by somewhereoutth »

iamthepieman wrote: post #76
merpnderp wrote: post #64

Earlier quoted context omitted.

Placebo effect accounts for changes in their blood markers for micro clots? I'm a big believer in the power of the mind, but this seems a stretch.

The point is that without a control group there's no way to know.

Something about parachutes

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#208

Post by edmcnulty101 »

dpark wrote: post #203
edmcnulty101 wrote: post #190

Earlier quoted context omitted.

I didn't see them misspeak. They just clarified. Their follow up statement was right in line with their original. Pretty cool that they're ahead of the curve on this. Even if they didn't know about long covid officially, they followed the known science up to that point, and this is incompletely but interesting new data that's showing it's helping more than possibly known at the time.

They’re not ahead of the curve. This long COVID treatment experiment is new and they equated it with an entirely different treatment. Saying “we knew this 2 weeks in” is dismissive and absurd. Knowing that NIH recommends anticoagulants for acute hospitalized COVID is entirely different than knowing that anticoagulants are useful for treating long COVID. If someone published a study that CTE resolves with a month of T…

They stated they knew from the scientific literature that anticoagulants were beneficial so I'm assuming they werent referring to long covid but to just general efficacy against covid, because long covid hadn't been discovered yet.

In that sense they were ahead of the curve because its looking like it is helpful with long covid as well, which is great news!

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#209

Post by ccn0p »

_jal wrote: post #106
ccn0p wrote: post #97

Earlier quoted context omitted.

Dissenting and getting downvoted, kind of proving the point. My experience living in a county and working in an industry that are both dominated by one particular way of thinking given to them by authority figures (CDC, New York Times, etc.) is that if you step outside that way of thinking and pose fairly innocuous questions that challenge it, two things happen: you lose all credibility, and you get called pretty bad…

> getting downvoted In the US, you're entitled to free speech. You're not entitled to respect, or even an audience. And I'm sorry, but if getting downvoted is political oppression to you, you need to grow some skin. > She covers a gambit of topics. I have read her. She's a boring and repetitive replacement-level whiner who's built a brand appealing to people with certain kinds of insecurities.

You're entitled to your opinion about someones work and that's fine, but I would hardly call her work repetitive, whining, or an appeal to insecurity. When people get "cancelled", she interviews them to get their side of the story (Winston Marshall). When someone writes what seems like pretty groundbreaking work using experience from years at the CIA, she interviews them (Martin Gurri - Revolt of the Public). When everyone ostracized the Central Park Karen, she interviewed a friend who had interviewed Amy Cooper while she was basically in hiding to get the other side of the story.

Feels like journalism to me.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#210

Post by surgeryres »

dpark wrote: post #175
GenerocUsername wrote: post #173

Earlier quoted context omitted.

I can tell you with absolute certainty that there are circles of of the web which knew incredible amounts of very accurate and precise details about COVID in Feb/March of 2020. The early mistreatments accounted for vast amounts of preventable deaths while people proposing the eventual correct solutions were deplatformed

1. I would love some actually citations rather than a hand-wavey claim that sounds like conspiracy theory. This sounds like you’re talking about hydroxychloroquine. 2. None of this matters to the claim I addressed. Long COVID it’s not something that would be treated in an ICU. It’s also not something that even had a name “when COVID hit”.

The problem the paper is addressing is fibrin micro clots, which occurs in long Covid. This also occurs in acute Covid. The treatment is similar - anti coagulation. We (doctors) knew this from the beginning (1). Chill out bubba.

(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378457/

Attached article was written during initial outbreak

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