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Europe's Vaccine Disaster

spiegel.de

201–210 of 434 posts

Re: Europe's Vaccine Disaster

#201

Earlier quoted context omitted.

EU pre-ordered more Pfizer than the US. Enough for 150 million people in EU, vs enough for 50 million in the US. The US has ordered more after it was approved.

The EU did not pay as much as the US — and signed the contracts much later. Pfizer is doing the rational actor thing and, given a shortage, prioritizing their highest paying clients. There might also be verbiage in the US contract to this effect. Also, Pfizer is an American company.

> Also, Pfizer is an American company.

BioNtech is a German company. If it would come down to national egotism, BioNtech would just kill the licensing deal and Pfizer wouldn't be allowed to produce anything.

Re: Europe's Vaccine Disaster

#202

Earlier quoted context omitted.

I wonder why not cover younger people with the GSK version and older people with some other vaccine?

Excellent question. Probably the biggest factor is that Phase III trials are insanely expensive, like a billion dollars plus or minus. High touch, 30,000 people minimum for the US, lasts two years, etc. Sanofi/GSK is hazarding some of their own money in this, and has to look at the market for COVID-19 vaccines, which is obviously weighted towards the elderly. Might also be risk management in wondering if the final re…

> Phase III trials are insanely expensive, like a billion dollars plus or minus

Do you have a source for that?

JAMA Internal Medicine says a median of 19 million, but that's for all drugs, not specifically vaccines.

https://jamanetwork.com/journals/jamainternalmedicine/articl...

Re: Europe's Vaccine Disaster

#203
A redacted version of the EU-AstraZeneca contract has been made public since the article was written:

https://www.reuters.com/article/uk-health-coronavirus-europe...

It's not clear to me but it seems that the EU wants AstraZeneca to use some additional factories in the UK that they're not currently using (?).

Re: Europe's Vaccine Disaster

#204
post #52

Earlier quoted context omitted.

Chinese and the Russian vaccines were not even considered. Now those are used in mass vaccinations, soon EU would be behind all countries but those who barely have any government at all. People don't even want to talk about that, as if those alternatives don't exists. Non-EU countries in Europe are getting them. Serbia(6.1) and Turkey(2.3) are already close to EU average(2.6) or better on the vaccination process.

The Russian scientists have first discussed Sputnik V with EMA (EU's medicine agency) 5 days ago: https://www.msn.com/en-xl/europe/top-stories/russia-files-sp... ; Hungary, which is part of the EU, has already given the vaccine emergency authorization. However, vaccination in Hungary is lagging behind its neighbors Austria and Romania due low levels of trust (in the Russian vaccine) and general antivaxx sentiment. Th…

It wouldn´t surprise me if Russia and China prioritize to sell the vaccines to other countries than attend their own population.

Re: Europe's Vaccine Disaster

#205

A redacted version of the EU-AstraZeneca contract has been made public since the article was written: https://www.reuters.com/article/uk-health-coronavirus-europe... It's not clear to me but it seems that the EU wants AstraZeneca to use some additional factories in the UK that they're not currently using (?).

Just saw this—the contract has been posted here:

https://news.ycombinator.com/item?id=25960469

Re: Europe's Vaccine Disaster

#206
post #52

Some had faith in the new mRNA technology, while others preferred to rely on more time-tested methods. Sometimes articles hide a great deal in one seemingly innocuous sentence. From what I've learned from Europeans, there's only one vaccine candidate of that nature the EU considered, a Sanofi Pasteur/GlaxoSmithKline combo, the former providing the infamous spike protein, the latter an adjuvant. Everyone expected this…

Chinese and the Russian vaccines were not even considered. Now those are used in mass vaccinations, soon EU would be behind all countries but those who barely have any government at all. People don't even want to talk about that, as if those alternatives don't exists. Non-EU countries in Europe are getting them. Serbia(6.1) and Turkey(2.3) are already close to EU average(2.6) or better on the vaccination process.

> Chinese and the Russian vaccines were not even considered.

The Russian vaccine's "trial" was mostly a non-consensual trial carried out on their military. I expect this lowered confidence.

Does China have a vaccine with decent effectiveness yet? Last time I read about it, the number was around 50%.

Re: Europe's Vaccine Disaster

#207

From what I've gathered (unfortunately mostly on Reddit, before this article), Ursula von der Leyen wasn't exactly fondly thought of in Germany before this and somehow keeps managing to fail upwards. Is that accurate? The utterly bonkers u-turn today was a bit of a shocker. For those that haven't seen the news, the European Commission managed to say they were effectively going to establish border controls between the…

Absolutely, the appeals to “fairness” have been particularly unedifying to hear whilst there are vast swathes of the world unable to access anything like the quantity of vaccine the EU has a hold on.

Re: Europe's Vaccine Disaster

#208

From what I've gathered (unfortunately mostly on Reddit, before this article), Ursula von der Leyen wasn't exactly fondly thought of in Germany before this and somehow keeps managing to fail upwards. Is that accurate? The utterly bonkers u-turn today was a bit of a shocker. For those that haven't seen the news, the European Commission managed to say they were effectively going to establish border controls between the…

I'm also pro-EU,remainer,etc. The problem is that the EU is the political graveyard, because countries send the most absurd people there. Not all of them,of course,but a lot. EU works when things are going slow and because of the sheer economical scale and power, everybody takes it serious when it comes to negotiations. But the EC isn't a bunch of experts on rapid situations. It's exactly the same when a French civil…

thats true. At least in Germany, you are just sent to the EU Parlament if you re not performing well in the country level.

Re: Europe's Vaccine Disaster

#209
post #177

Earlier quoted context omitted.

The Russian Gam-COVID-Vac/Sputnik V vaccine looks very good, but for the US or to much of the West, there's a price to be paid for being in an effective state of war with another country. Although Gamaleya is now working with AZ/Oxford to see if substituting one of their doses for one of Oxford's will produce much better results, which I never would have expected. This is based on the theory that the immune system re…

> the theory that the immune system response to Oxford's virus vector is mostly negating the benefit of the second dose taken 21 days after the first Do you know if there are more trials underway to verify this? I'm guessing it ties in to AZ's encouragement for delaying the second dose i.e. wait until the immune response has died down. I think UK medical consensus is currently recommending 12 weeks rather than the or…

The 12 weeks is not about maximizing protection for an individual recipient, but was a decision made solely to get the first dose to more people faster.

In terms of effect on effectiveness per person it is purely speculative.

Re: Europe's Vaccine Disaster

#210

Earlier quoted context omitted.

This. Singapore, an ethnically Chinese country, has announced they're buying Moderna, BioNTech and (Chinese) Sinovac, and approximately nobody trusts or wants to take the Chinese one.

I'm in Venezuela and we're apparently only getting the Russian vaccine. I haven't met the first person that says they're willing to get it.

It’s not like you would be the first people to get vaccinated with sputkin-V, you know. Rollout in Russia is slow (as per usual), but my whole family got at least one dose already, and we are all fine. No third arms, no blood, coming out of our eyes.

Russian vaccine is ok. Don’t know how true the effectiveness numbers are, but I don’t believe they are significantly lower in reality then on paper.

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