Johnson and Johnson single-shot vaccine appears 66% effective in global trial • Hacker News Board

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#201

Post by jamesrcole » Sat, Jan 30, 2021, 1:42 AM UTC

coding123 wrote: post #184

martin1975 wrote: post #155

Earlier quoted context omitted.

Gold standard? They have not been previously used on us humans and there are far more side-effects w/mRNA than traditional vaccines. I'll take J&J's '66%' over any mRNA vaccine.

Downvotes without replies again. It is definitely worth debate. What if J&J's second shot gets it up to the same 95%? (even if they are not advocating a second shot at this time) After all, these vaccines do not prevent the virus directly, they're just there to coax the body to produce new things. Both teach the body about the spike protein. It does seem like the mRNA vaccines are given a not-yet-due congratulations…

> Downvotes without replies again.

Looking at that comment it might be because it just asserts “there are far more side-effects w/mRNA than traditional vaccines” without any explanation or sources.

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#202

Post by timr » Sat, Jan 30, 2021, 1:46 AM UTC

mewse wrote: post #162

_Understated_ wrote: post #112

Earlier quoted context omitted.

> It isn’t possible to protect the vulnerable while having rampant covid in the young and healthy, society doesn’t work like that. Then why do the numbers keep going up despite locking down everyone? Why didn't governments institute a policy that keeps people away from those in vulnerable groups with a £1000 fine for breaches? Mandated masks etc. That would have been just as manageable. Lockdowns do not work, the fig…

> Lockdowns do not work Hi, Victoria, Australia here. Today, our state is at 24 days of zero community transmission of covid, managed largely via a small lockdown after a small outbreak from interstate. Before that small outbreak, we were up to 80-ish days of zero community transmission of covid, after a much much larger outbreak which was brought under control by a robust lockdown which began in March and continued…

> Today, our state is at 24 days of zero community transmission of covid, managed largely via a small lockdown after a small outbreak from interstate. Before that small outbreak, we were up to 80-ish days of zero community transmission of covid, after a much much larger outbreak which was brought under control by a robust lockdown which began in March and continued into December. Lockdowns work, if people obey them. And we’re proof of that.

So let's re-phrase: you had one of the longest lockdowns in the world (110 days), spanning the fall, winter and spring...and then it came back in the summer, and you had to do it again. And you're in an isolated island nation with almost no international travel.

Your story does not encourage me about the feasibility of the strategy you advocate -- it underscores how tenuous the situation actually is.

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#203

Post by dev_tty01 » Sat, Jan 30, 2021, 1:47 AM UTC

_Understated_ wrote: post #101

xxpor wrote: post #98

Earlier quoted context omitted.

Given that high blood pressure, and being overweight are concidered underlying conditions, people with "no underlying conditions" might be < 20% of the total population.

We're talking about serious stuff: cancer, immune disorders, diabetes, obesity etc.

It is not a short list. Here is the list of high risk conditions for age 16-64 from my health department.

Cancer, Chronic kidney disease, COPD (chronic obstructive pulmonary disease), Heart conditions, such as heart failure, coronary artery disease, or cardiomyopathies, Immunocompromised state (weakened immune system) from solid organ transplant, Overweight (BMI > 25 kg/m2, but Now, include the people who live with anyone with those conditions or the people who care or regularly interact with people with these conditions. We end up with a large percentage of the population. The proposal to lockdown/isolate only people with higher risk conditions is completely impractical.

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#204

Post by coding123 » Sat, Jan 30, 2021, 1:50 AM UTC

djrogers wrote: post #190

martin1975 wrote: post #155

Earlier quoted context omitted.

Gold standard? They have not been previously used on us humans and there are far more side-effects w/mRNA than traditional vaccines. I'll take J&J's '66%' over any mRNA vaccine.

Claiming that there are ‘far more side effects’ is more than a little disingenuous, and smacks of either ignorance or willful misrepresentation of the facts here.

Can you help me find the covid-19 side effects tracking website? I can't seem to find it. In fact I can't find anything that's enumerating the data publicly. I can't answer your comment at all without any data.

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#205

Post by greesil » Sat, Jan 30, 2021, 1:53 AM UTC

henrikschroder wrote: post #179

birken wrote: post #148

Earlier quoted context omitted.

I'm quite confident people probably over-estimate their chance of dying in a plane crash by a few orders of magnitude as well. People are careful about their own lives, which is probably a good survival mechanism. What specific policy are you suggesting? The more As far as I'm aware no place has let the virus spread uncontrollably, think everything was fine, and not lock down at some point. The policy clearly has to…

> What specific policy are you suggesting? I think the biggest problem is the hyper-focus on a single cause of death. People look at the covid-19 death numbers, and have no idea how many people actually die in a normal year. And this causes people to focus on ensuring nobody dies of covid-19 to the exclusion of everything else. Yes, it absolutely sucks that a lot of vulnerable people in elder care facilities have die…

Yeah, this is a false dichotomy. There are other options other than lockdown vs no lockdown. You can have a social safety net and pay people to stay home. But if you're insistent that these are the only two options, look at Sweden. Their economy suffered despite not locking down last year because guess what, it turns out people don't want to go out and risk dying. So if your economy is doing to have mass unemployment, you may as well do that and avoid the death and injury. Or better yet, borrow at low interest rates and let people be unemployed but not destitute.

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#206

Post by greedo » Sat, Jan 30, 2021, 1:59 AM UTC

jtxxwl2 wrote: post #189

andybak wrote: post #185

Earlier quoted context omitted.

Sorry. Can you expand on this argument? In it's current form it makes almost no sense.

Public health experts, in the US and other western countries, deserve no credibility due to their handling of the obesity crisis. There are clear and obvious steps that governments could take to end obesity, but public health experts have failed to even make an effort to make them happen. Instead they have sat by and watched millions upon millions of people become obese, which is vastly more harmful to the average pe…

Oh yes. I'm sure that a population that can't follow simple recommendations to wear a damn mask will listen to the CDC when it says to stop eating Big Macs.

And if you would like to become educated on the government's role in fighting obesity, and its recommendations, you can go to https://www.cdc.gov/obesity/strategies/index.html

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#207

Post by randomopining » Sat, Jan 30, 2021, 2:32 AM UTC

zeku wrote: post #65

bpodgursky wrote: post #26

Earlier quoted context omitted.

That's only if you include all infections within the two week window between shots. If you look at the tail end (ie, after the shot has time to be effective) it seems more like 90.

The issue with this is that it's the SECOND shot that gives you your long term immunity. If you only get one shot your immunity is allegedly going to wane somewhat quickly. edit: for pfizer & moderna.

Where did you see that part? Any reason why the 2nd one makes it last that much longer?

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#208

Post by TylerE » Sat, Jan 30, 2021, 2:35 AM UTC

matteotom wrote: post #191

interestica wrote: post #182

Earlier quoted context omitted.

What is the optimal vaccination strategy? So far, it just seems like we're following "vaccinate healthcare workers and the most vulnerable" and that, on the surface, seems intuitive. But is there some other sort of algorithm that can determine the best way to reduce overall transmission the fastest? Random vaccinations? Targeted groups in different regions? Double shots for vulnerable before single shots for others?…

One strategy, which wouldn't be applicable to most places in the United States right now, is to target a couple levels of potential contacts of every case. So when a person tests positive, you vaccinate all their contacts, and then all those people's contacts, and you can be pretty sure to have broken that line of transmission.

That's far too late. It takes weeks for the vaccine to become effective.

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#209

Post by niyrjczs » Sat, Jan 30, 2021, 2:40 AM UTC

greedo wrote: post #206

jtxxwl2 wrote: post #189

Earlier quoted context omitted.

Public health experts, in the US and other western countries, deserve no credibility due to their handling of the obesity crisis. There are clear and obvious steps that governments could take to end obesity, but public health experts have failed to even make an effort to make them happen. Instead they have sat by and watched millions upon millions of people become obese, which is vastly more harmful to the average pe…

Oh yes. I'm sure that a population that can't follow simple recommendations to wear a damn mask will listen to the CDC when it says to stop eating Big Macs. And if you would like to become educated on the government's role in fighting obesity, and its recommendations, you can go to https://www.cdc.gov/obesity/strategies/index.html

Telling people not to eat McDonald's is the best you can come up with?

How about requiring every high school student to spend two hours per day doing strenuous physical exercise in order to graduate? How about considering it a failure for a student to graduate without being in excellent athletic form, on par with the student being unable to do algebra?

If the people in charge wanted to make that happen, they could do it by spending a tiny fraction of the public money at their disposal on propaganda, but all indications are that they don't want a population that's in great physical shape, even though it would obviously be good for them.

People who are in great shape when they graduate high school might still become fat, but people who graduate from high school fat will almost certainly spend their lives that way.

They could also regulate extremely sugary foods like how tobacco, which is less harmful, is regulated, where you have to be 18 to buy it and have to ask for the cashier to get it for you, rather than having it in your face at the checkout aisle.

Whining about how hard it is on their website is exactly the sort of reason why they have no credibility. They're not really trying, and pretty much everyone can sense that, even if they don't have it spelled out for them.

Re: Johnson and Johnson single-shot vaccine appears 66% effective in global trial

#210

Post by lostlogin » Sat, Jan 30, 2021, 2:43 AM UTC

timr wrote: post #202

mewse wrote: post #162

Earlier quoted context omitted.

> Lockdowns do not work Hi, Victoria, Australia here. Today, our state is at 24 days of zero community transmission of covid, managed largely via a small lockdown after a small outbreak from interstate. Before that small outbreak, we were up to 80-ish days of zero community transmission of covid, after a much much larger outbreak which was brought under control by a robust lockdown which began in March and continued…

> Today, our state is at 24 days of zero community transmission of covid, managed largely via a small lockdown after a small outbreak from interstate. Before that small outbreak, we were up to 80-ish days of zero community transmission of covid, after a much much larger outbreak which was brought under control by a robust lockdown which began in March and continued into December. Lockdowns work, if people obey them.…

People rail against lockdowns and claim eradication isn’t possible for various reasons, yet when shown examples of where it has worked and the freedoms it has allowed somehow that is also not an option.

If everyone did it, we would have a solution.

What Victoria achieved looked an impossible task for a while there, and shows that a severe outbreak can be corrected. That’s an achievement that can’t be underestimated.

Why anyone in Australia or NZ would want to travel internationally for anything other than absolutely essential travel is baffling to me - outside of travel, we have achieved normality. Rampant covid and freedom of movement is not the freedom I want.