1. Boulder 2. Austin 3. Omaha 4. Des Moines 5. Reno (the real sleeper, but just look at the low, low business tax rate and proximity to SF).
The above list isn't meant to be chiseled into stone—it's just a thought experiment on my part and I'm interested in what others think the pros/cons of these towns would be. The obvious con would be the lack of proximity to investor and startup networks and that ecosystem.