I'm no scientographer, but it seems to me that a dependence on helium may be a stumbling point for getting cheap vacuum transistors to the market. The ongoing helium shortage[1] is driving the price of helium up which could make helium-based vacuum transistors expensive, limiting widespread adoption. It could be that high-speed helium vacuum transistors become a speciality product for those projects that feel the nee…
Oh, sure, there will be losses and such, but this is still a trivial expense next to the billions of dollars of fab work that will be required. In these quantities we literally use gold without hardly a second thought for price.
[1]: http://www.praxairdirect.com/Product2_10152_10051_14626_-1_1...