Ibogaine treatment is the best way to get over heroin addiction (apart from strong will power of course).
The Anti-Addiction Pill That's Big Business For Drug Dealers
21–30 of 47 posts
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#22I suspect the private prison industry, some in law enforcement and politicians do not want this drug readily available. It could be significantly disruptive to their wallets and positions of power.
This is actually a really good point, and I'm glad you backed it up with concrete evidence.
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#23Only take bupenorpine if you are really addicted to heroine. Doctors who prescribe for opiate addiction are allowed only 100 patients. They(Doctors) will drag you in for needless expensive visits. I say only if you are really addicted to opiates, because I see people switching to this drug because they "think" they are addicted. The drug is not something you want to get addicted too. If you do end up on this drug, tr…
Despite its flaws, calling the 12 step program a "dance" is pretty offensive. This coming from a someone who's father died of alcohol withdraw when I was young, and 4 immediate family members in the program.
*edit: Also, while your post was primarily about this pill and addiction surrounding it, I can assure you my father wasn't like "Jerry Garcia.(huge addiction, obese, and diabetic, etc)." In fact, he was in his mid-twenties, and an all-state wrestler and football player in high school, and very athletic after. Sometimes, it has nothing to do with your health, but the seizures which can come from withdraw and an inadequate and unequipped healthcare system.
To be frank, I find your post to be very insensitive and offensive to those who have been through situations like this.
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#24As an interesting aside, the company that makes Suboxone attempted to prevent generic companies from entering the market.
Apparently there have been a number of poisoning caused by children taking Suboxone tablets. What Reckitt (the maker of Suboxone) did was create a new dose in the form of a film that dissolves in your mouth. Each film came in a seal packet that was difficult for children to open.
Once the patent for Suboxone was nearing expiration, Reckitt introduced the new film dose form and pulled the tablets off the market. Once the patent expired, Reckitt asked the FDA to deny approval of any new generic forms of the tablets in the interest of public safety (in essence giving them an additional patent life as the film was a new patent).
The FDA didn't believe the risk was enough to stop generic versions of Suboxone and two new generic forms were approved earlier this year [1].
[1] http://www.drugfree.org/join-together/government/fda-approve...
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#25Earlier quoted context omitted.
So does this mean that the opiate addiction is still present, but satisfied by suboxone? In other words, if you stopped taking suboxone, would the heroin craving come back?
Soboxone targets opioid receptors differently than heroin and, while it is technically a "replacement therapy" it is almost impossible to overdose on and more difficult to use on a continual basis for recreational purposes (the "positive" effects of the drug decay rapidly with continual use. To answer the question, one does experience withdrawal effects if they use Buprenorphine for a long enough time, however some p…
Suboxone still works through the same receptors as morphine or heroin (see the wiki link).
One important difference is that it's a partial agonist at the mu receptors rather than a full agonist. That makes the effects someone self limiting.
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#26Only take bupenorpine if you are really addicted to heroine. Doctors who prescribe for opiate addiction are allowed only 100 patients. They(Doctors) will drag you in for needless expensive visits. I say only if you are really addicted to opiates, because I see people switching to this drug because they "think" they are addicted. The drug is not something you want to get addicted too. If you do end up on this drug, tr…
> Remember, you will be addicted to another drug
True, but there is a ceiling to the effects, so your dose can't escalate endlessly. It also blocks other opiates, by binding very tightly to the receptor.
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#27Earlier quoted context omitted.
Soboxone targets opioid receptors differently than heroin and, while it is technically a "replacement therapy" it is almost impossible to overdose on and more difficult to use on a continual basis for recreational purposes (the "positive" effects of the drug decay rapidly with continual use. To answer the question, one does experience withdrawal effects if they use Buprenorphine for a long enough time, however some p…
Suboxone still works through the same receptors as morphine or heroin (see the wiki link). One important difference is that it's a partial agonist at the mu receptors rather than a full agonist. That makes the effects someone self limiting.
I didn't say that it targets different receptors. I said it targets them (i.e. the same receptors) differently. I failed to go into the details of how it targets them differently (wasn't sure if that LOD was called for, or in good taste, considering that this is not a site about pharmacology or neurochemistry). I did see the wiki link... (I wouldn't have posted it if I hadn't.) Thank you for clarifying though! (BTW, I think that you meant somewhat not someone in your final sentence.)
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#28Earlier quoted context omitted.
Suboxone still works through the same receptors as morphine or heroin (see the wiki link). One important difference is that it's a partial agonist at the mu receptors rather than a full agonist. That makes the effects someone self limiting.
I didn't say that it targets different receptors. I said it targets them (i.e. the same receptors) differently. I failed to go into the details of how it targets them differently (wasn't sure if that LOD was called for, or in good taste, considering that this is not a site about pharmacology or neurochemistry). I did see the wiki link... (I wouldn't have posted it if I hadn't.) Thank you for clarifying though! (BTW,…
(wasn't sure if that LOD was called for, or in good taste, considering that this is not a site about pharmacology or neurochemistry).
In my experience, detailed knowledge is always welcome on Hacker News, especially if it comes from another highly technical field outside software.
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#29Earlier quoted context omitted.
I didn't say that it targets different receptors. I said it targets them (i.e. the same receptors) differently. I failed to go into the details of how it targets them differently (wasn't sure if that LOD was called for, or in good taste, considering that this is not a site about pharmacology or neurochemistry). I did see the wiki link... (I wouldn't have posted it if I hadn't.) Thank you for clarifying though! (BTW,…
(wasn't sure if that LOD was called for, or in good taste, considering that this is not a site about pharmacology or neurochemistry). In my experience, detailed knowledge is always welcome on Hacker News, especially if it comes from another highly technical field outside software.
Totally, my error for not adding value with some additional information in my last comment. Thank you. :)
1) some introductory material on receptor theory:
http://en.wikipedia.org/wiki/Receptor_theory
Yes, I know Wikipedia, a more comprehensive intro to basic neuro is "Principles of Neural Science, 5th Ed" (http://www.mhprofessional.com/product.php?isbn=0071390111)... It's large book but the de facto standard.
2) a reference to some basic pharmacology with respect to opioid receptors that includes a summary discussion on receptor interactions (i.e. full agonists/antagonists/partial agonists):
http://www.ncbi.nlm.nih.gov/books/NBK64236/
3) some explanation per the specifics of the mu receptor (click on this only if you are truly thirsting for knowledge on the mu receptor):
http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objec...
Have a nice night!
Re: The Anti-Addiction Pill That's Big Business For Drug Dealers
#30Earlier quoted context omitted.
So does this mean that the opiate addiction is still present, but satisfied by suboxone? In other words, if you stopped taking suboxone, would the heroin craving come back?
Yes, the addiction is still present. If I stop taking suboxone I will start feeling a little bad (depression, etc) by day 2 and will start withdrawing (feels like a really bad cold) on day 3. By day 4, I would be throwing up and unable to move/function. The only downside of suboxone is that due to its long half-life, the withdrawals last a long, long time. With heroin you are out of the woods by day 4 or 5, but with…
It is immediately clear that is too addictive for all but the worse cases. What would happen if instead of taking this stuff you were supervised by a physician during withdrawal? Would you be addiction free after 2 weeks?