Well.....what could possibly go wrong there? There have been several air disasters over the years that resulted from a failure to flip the right switch or check certain settings, either in-flight or pre-flight. A Greek crash where the pilot forgot to flip the auto-pressurization switch, killing most on board before the crash itself, comes to mind. This video leaves little wonder why these things happen.
Having spent 18 years trying to design software and websites to be idiot-proof, to me it looks like they could seriously use some human-friendly UI and procedure design. When the stakes are as high as they are during a packed commercial flight, it would seem to me that maximum possible simplicity would be the goal. Perhaps a "flight checklist wizard". It is possible to enable the granular control that pilots need without making them this complex.