By zope, i assume you mean Zope2.
Nobody uses zope? really? Plone, arguably the best Open Source CMS out there is built on Zope2 and continues to be used in ever increasing numbers..
Zope3 is not just a "framework". Its a mindset that allows people to think about solving problems in a robust way, which will remain useful for software's lifecycle.
Zope people realized the danger in building monolithic frameworks after the experiences of Zope2. When they started zope3, they kept the goal of reusability the number one design goal, even at the risk of appearing over-engineered at times. Today, there is no Zope3 and Zope3 is everywhere. Zope lives in Plone, Repoze, Grok and myriad of python libraries.
Lot of good ideas from zope like Zope.Interfaces and Zope component architecture are being outside the zope community.
Django is the Zope2 of 2009.
How many software stacks are still being supported and catered for after 10 years? Zope is a greybeard but saying that nobody uses it implies lack of actual knowledge of python frameworks and how they play together.