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Trials on veterans suggest ibogaine could provide a new treatment for PTSD

bbc.com

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Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#21

Post by AndrewKemendo »

dacops wrote: post #8

Only veterans? I wonder about the editorial choice to use veterans rather than, say, women who have PTSD from assaults, which is a much larger group of people. (Approximately 4% of US men and 8% of US women experience PTSD every year across all reasons like accidents, sexual assaults, combat, etc.) Presumably this treatment would help everyone? Or is it somehow supporting only vets?

People like to use us war veterans to wash their agendas through

We’re one step below “think of the children”

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#22

Post by AndrewKemendo »

vasco wrote: post #10
dacops wrote: post #8

Only veterans? I wonder about the editorial choice to use veterans rather than, say, women who have PTSD from assaults, which is a much larger group of people. (Approximately 4% of US men and 8% of US women experience PTSD every year across all reasons like accidents, sexual assaults, combat, etc.) Presumably this treatment would help everyone? Or is it somehow supporting only vets?

Vets kill themselves a lot so I guess it's easier to propose crazier stuff because the alternative is very bad.

Though notably never anything really crazy like “let’s stop doing war”

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#23

Post by justonceokay »

mawadev wrote: post #14

Does it really help or are they just too dissociated after taking it

As someone who takes antidepressants this is nonsensical to me. I don’t feel 100% normal on an SSRI, I experience the normal side-effects of flat affect and weird tastes, etc. But the alternative is regular panic, exhaustion, indigestion, and general volatility that makes my life difficult and hard for others to interact with me.

If dissociation is better than regular PTSD, then go for it. We don’t expect people with hip replacements to have 100% mobility. We don’t expect cochlear implants to hear better than healthy ears. Mental health interventions have similar tradeoffs.

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#25

Post by sriacha »

galangalalgol wrote: post #5
boxed wrote: post #4

Earlier quoted context omitted.

Or LSD, or magic mushrooms.

I've been assuming it was some sort of profit motive as TX has been pumping money into it. It seems like there might actually be science driven though. For tramatic brain injury combined with ptsd ibogaine causes a release of glial cell factors that help neuroplasticity wire around the damage. Its also horribly unsafe from a cardiac perspective so you would need a constant eeg during therapy driving up prices. So pro…

Not really "horribly unsafe", it seems that with proper prescreening and magnesium supplementation cardiac risk can be safely managed. I was looking into this a few weeks ago.

However there is certainly a lack of data, and facilities doing treatment now are probably incentivized not to share adverse events.

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#26

Post by JCTheDenthog »

AndrewKemendo wrote: post #22
vasco wrote: post #10

Earlier quoted context omitted.

Vets kill themselves a lot so I guess it's easier to propose crazier stuff because the alternative is very bad.

Though notably never anything really crazy like “let’s stop doing war”

I mean, that does sound pretty crazy. Specific wars are often ill-advised or largely pointless, but "stop doing war" presupposes that all other countries in the world will also "stop doing war", otherwise what you're suggesting is just unilateral surrender under the guise of stopping war.

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#27

Post by sriacha »

Another very interesting possible benefit of ibogaine not mentioned in the article is potential for treating TBI.

from https://pubmed.ncbi.nlm.nih.gov/41883580/:

>Longitudinal analyses assessed cortical thickness, subcortical volume, and predicted brain age (pBA), estimated from T1 scans. pBA was significantly reduced at 1 month relative to baseline (-1.3 years). Cortical thickness analysis revealed post-treatment increases in 11 regions. Subcortical analyses revealed significant volumetric expansion in 8 regions. Magnesium-ibogaine therapy was associated with increased cortical thickness, subcortical expansion, and reduced pBA at 1 month.

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#28

Post by dlcarrier »

dacops wrote: post #8

Only veterans? I wonder about the editorial choice to use veterans rather than, say, women who have PTSD from assaults, which is a much larger group of people. (Approximately 4% of US men and 8% of US women experience PTSD every year across all reasons like accidents, sexual assaults, combat, etc.) Presumably this treatment would help everyone? Or is it somehow supporting only vets?

It's who the trials are done on. US veterans have their own health care system, so that may have played a role in why they were targeted for the research.

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#30

Post by KolibriFly »

dacops wrote: post #8

Only veterans? I wonder about the editorial choice to use veterans rather than, say, women who have PTSD from assaults, which is a much larger group of people. (Approximately 4% of US men and 8% of US women experience PTSD every year across all reasons like accidents, sexual assaults, combat, etc.) Presumably this treatment would help everyone? Or is it somehow supporting only vets?

I read it less as "this only helps veterans" and more as "veterans are the group this particular research and funding path is centered on"
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