Nuclear receptor 4A1 linked to health effects of coffee: study • Hacker News Board

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#21

Post by nemomarx » Sun, May 03, 2026, 5:13 PM UTC

ai_slop_hater wrote: post #16

technothrasher wrote: post #14

Earlier quoted context omitted.

Yes, I know the four main methods of decaffeination. The haters have gone down this road with me many times. Why can't people just let me drink my decaf? It's like they can't enjoy their caffeine unless everybody does. It's weirdly pushy.

[flagged]

Why? Coffee tastes good. What's wrong with drinking something that you like the taste of, or just a warm drink in general?

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#22

Post by cf100clunk » Sun, May 03, 2026, 5:16 PM UTC

steve_adams_86 wrote: post #15

cf100clunk wrote: post #13

Earlier quoted context omitted.

Are you researching whether you'll get cancer if you are extracting 100% pure nicotine and ingesting it? Who does that?

A lot of people consume nicotine. It has been isolated and used in products for a long time. There's no clear link to cancer, but it could impact cardiovascular health (like all stimulants seem to). Some research indicates that nicotine can influence how existing cancer behaves and spreads, so that's worth considering.

Right, point taken, but I wasn't following how nicotine properties were connected to coffee's health benefits.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#23

Post by coffeebeqn » Sun, May 03, 2026, 5:17 PM UTC

cf100clunk wrote: post #13

jonnybgood wrote: post #10

Earlier quoted context omitted.

Is there research that links nicotine to cancer? I’m unable to find anything that would suggest nicotine as cancer causing.

Are you researching whether you'll get cancer if you are extracting 100% pure nicotine and ingesting it? Who does that?

Most nicotine users today? Everyone’s using the pure nicotine pouches like zyn and such. I didn’t really find it enjoyable at all

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#24

Post by Bridged7756 » Sun, May 03, 2026, 5:19 PM UTC

RobRivera wrote: post #19

I need more dopamine headlines like this to justify my dopamine addiction to coffee.

Not everything is dopamine. Maybe nitpicky on my end but it gets tiresome when everyone is just like dopamine this, dopamine that, when no one really understands neurotransmitters.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#25

Post by jayd16 » Sun, May 03, 2026, 5:19 PM UTC

technothrasher wrote: post #5

"While caffeine is the major individual component of coffee, the study suggests that it may not be the primary driver of these health effects." All you haters that give me grief for drinking my daily cup of decaf can shut up now.

The decaf tries to warn you itself with its bright carafe colorings. In nature that means "Do not touch me, I am poison."

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#26

Post by Jaxan » Sun, May 03, 2026, 5:20 PM UTC

ai_slop_hater wrote: post #16

technothrasher wrote: post #14

Earlier quoted context omitted.

Yes, I know the four main methods of decaffeination. The haters have gone down this road with me many times. Why can't people just let me drink my decaf? It's like they can't enjoy their caffeine unless everybody does. It's weirdly pushy.

[flagged]

If you don’t like the taste, you shouldn’t drink it, imo. So yes, one enjoys coffee exactly for the flavour.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#27

Post by Bridged7756 » Sun, May 03, 2026, 5:22 PM UTC

I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#28

Post by avidiax » Sun, May 03, 2026, 5:23 PM UTC

gleenn wrote: post #12

markus_zhang wrote: post #8

I wonder whether decaf still contains these chemicals. I drank two cups of decaf every day.

TFA mentions that decaf contains these properties as well.

Not exactly, the article says that the effects aren't linked to caffeine, not that decaf has been shown to have the positive effects or still contain the necessary chemicals.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#29

Post by pawelduda » Sun, May 03, 2026, 5:28 PM UTC

Seems to also be relevant for yerba mate which also contains chemical compounds that bind to NR4A1

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#30

Post by tyre » Sun, May 03, 2026, 5:28 PM UTC

ai_slop_hater wrote: post #16

technothrasher wrote: post #14

Earlier quoted context omitted.

Yes, I know the four main methods of decaffeination. The haters have gone down this road with me many times. Why can't people just let me drink my decaf? It's like they can't enjoy their caffeine unless everybody does. It's weirdly pushy.

[flagged]

Criticizing someone for their subjective preference in drinks is incredibly weird.