Live data from Hacker News

MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

sciencedaily.com

21–30 of 108 posts

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#21
I'd argue that the results might not be from the drugs but from the fact that they were heavily monitored by other humans.

It's not the drugs that people with high anxiety need, it's people giving them attention and caring for them.

These experiments need a control where they just take the drug and they don't have medical staff around.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#23
post #5

It seems like every few weeks there's an article on how drugs are amazing hitting the front-page.

HN has some peculiar medical fixations. It comes in waves. For a while there were a lot of submissions about intermittent fasting. 15 years ago people were excited about polyphasic sleep. 10 years ago it was all about modafinil. Enthusiasm about ketamine for depression was big, but it seems to have finally fizzled out.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#24

I'd argue that the results might not be from the drugs but from the fact that they were heavily monitored by other humans. It's not the drugs that people with high anxiety need, it's people giving them attention and caring for them. These experiments need a control where they just take the drug and they don't have medical staff around.

Isn't that basically the same as them using a placebo? If just care has the same effect, then surely heavily monitoring them while providing a placebo drug should work.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#25
I’d be afraid of a treatment like this where you’re sort of different after one treatment. From experience taking ssris, I took one one that worked so well that I had to stop taking it because it removed stress to the extent that I wouldn’t get to class on time or get my homework done before deadlines. Eventually I found a medicine that worked for me. But, if there’s a “before” vs “after” one shot treatment, you have to hope the new you is the one you want assuming you could be stuck there permanently.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#26

I'd argue that the results might not be from the drugs but from the fact that they were heavily monitored by other humans. It's not the drugs that people with high anxiety need, it's people giving them attention and caring for them. These experiments need a control where they just take the drug and they don't have medical staff around.

"In this phase 2b, multicenter, randomized, double-blind, placebo-controlled study of 4 dose levels of MM120 that included 198 adults with generalized anxiety disorder, the primary outcome of a dose-response relationship for change in Hamilton Anxiety Rating Scale score at week 4 was statistically significant."

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#27

I’d be afraid of a treatment like this where you’re sort of different after one treatment. From experience taking ssris, I took one one that worked so well that I had to stop taking it because it removed stress to the extent that I wouldn’t get to class on time or get my homework done before deadlines. Eventually I found a medicine that worked for me. But, if there’s a “before” vs “after” one shot treatment, you have…

A good point, but if stress was your motivator, it might be better to work to reframe that and gain motivation through something else that isn't stress.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#28

I’d be afraid of a treatment like this where you’re sort of different after one treatment. From experience taking ssris, I took one one that worked so well that I had to stop taking it because it removed stress to the extent that I wouldn’t get to class on time or get my homework done before deadlines. Eventually I found a medicine that worked for me. But, if there’s a “before” vs “after” one shot treatment, you have…

When you have heavy generalized anxiety, you are usually willing to commit to that if it means there is a significant probability of coming out with an improved condition. I had such terrible panic attacks before my treatment with a bunch of different medication that I seriously considered and searched for electroconvulsive therapy and even help from shady religious institutions.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#29

I’d be afraid of a treatment like this where you’re sort of different after one treatment. From experience taking ssris, I took one one that worked so well that I had to stop taking it because it removed stress to the extent that I wouldn’t get to class on time or get my homework done before deadlines. Eventually I found a medicine that worked for me. But, if there’s a “before” vs “after” one shot treatment, you have…

When you have heavy generalized anxiety, you are usually willing to commit to that if it means there is a significant probability of coming out with an improved condition. I had such terrible panic attacks before my treatment with a bunch of different medication that I seriously considered and searched for electroconvulsive therapy and even help from shady religious institutions.

I might have gotten that desperate myself, but I finally found a great physiatrist that gave a shit and was competent. Simply taking Effexor removed my panic attacks without problematic side effects.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#30

Earlier quoted context omitted.

When you have heavy generalized anxiety, you are usually willing to commit to that if it means there is a significant probability of coming out with an improved condition. I had such terrible panic attacks before my treatment with a bunch of different medication that I seriously considered and searched for electroconvulsive therapy and even help from shady religious institutions.

I might have gotten that desperate myself, but I finally found a great physiatrist that gave a shit and was competent. Simply taking Effexor removed my panic attacks without problematic side effects.

Yeah, changing psychiatrists also helped me. Unfortunately, I had to change drugs a couple of times and ended up taking multiple ones to end my panic attacks. Those drugs left me with long lasting tremors, even after I've stopped taking them, but the tremors are 10000x better than the panic attacks.
Post reply on HN