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Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

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Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#21

Post by squigz »

Loughla wrote: post #14
dmorgan81 wrote: post #11

Earlier quoted context omitted.

Have you tried L-theanine? I also get panic attacks with weed, but L-theanine seems to help keep them at bay.

I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…

Have you tried edibles or another method than smoking?

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#22

Post by [deleted] »

Aurornis wrote: post #10

I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…

[deleted]

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#23

Post by wafflemaker »

Loughla wrote: post #14
dmorgan81 wrote: post #11

Earlier quoted context omitted.

Have you tried L-theanine? I also get panic attacks with weed, but L-theanine seems to help keep them at bay.

I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…

Always thought that panic attacks were caused by too low CBD in regards to THC levels.

Saw someone literally suggesting keeping a CBD vape pen just in case of a panic attack. Or a friend using it for heart palpitations.

Wasn't the amount of THC concentration in resin seen as the indicator of potency? Then that amount was hacked through selective breeding, unbeknownst that not following with a complementary increase in amount of CBD will create an anxiety causing superdrug.

I experienced it once - on a party in a country where CBD strains are legal to buy by anyone, as long as they contain ~0%THC. And high quality high THC strains can be bought at a pharmacy with a prescription.

A friend rolled a 50%/50% joint, approx 0.5g total, and we proceeded to smoke it whole, just the two of us. I was surprised you could get that high without a shadow of a paranoia.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#25

Post by esperent »

dmorgan81 wrote: post #11
rusakov-field wrote: post #7

Man, too bad weed gives me bad panic attacks. Alzheimers is the scariest disease I know so maybe if the studies pan out in time and it becomes a standard preventative, I might consider trying again. But somehow I doubt it will be found to be that effective.

Have you tried L-theanine? I also get panic attacks with weed, but L-theanine seems to help keep them at bay.

I have tried l-theanine, didn't do anything that I could tell.

But fortunately there's a much better solution for those of us who get anxiety from weed, it's called "don't smoke weed".

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#26

Post by jcranmer »

Too bad we've had like a half-dozen putative Alzheimer's drugs that clear amyloid beta that turn out to do nothing to slow or prevent Alzheimer's.

Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#27

Post by mrosett »

Aurornis wrote: post #10

I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…

Reminds me of this classic: https://xkcd.com/1217/

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#28

Post by colordrops »

Anecdotally, when I'm feeling scattered and foggy, when I take a big hit off of my vape pen, I go through a period of noticing how shaky my appendages are, and go through what feels like a physical process of the sensation of my mind "unwrinkling" or unfurling. I often wondered if something was being cleaned out in my brain because I usually feel a lot more calm and still afterward, thoughts more collected.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#30

Post by nikkwong »

jcranmer wrote: post #26

Too bad we've had like a half-dozen putative Alzheimer's drugs that clear amyloid beta that turn out to do nothing to slow or prevent Alzheimer's. Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?

That's not true. Monoclonal antibodies are on the market right now which slow the progression of the disease (by removing amyloid).
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