Appears that it is trying to stimulate broad immunity .. instead of any one specific virus/disease. Artificial and overstimulation of our immune systems long-term can't be healthy. Definitely a tradeoff here.
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Universal vaccine against respiratory infections and allergens
21–30 of 159 posts
Re: Universal vaccine against respiratory infections and allergens
#22[flagged]
Re: Universal vaccine against respiratory infections and allergens
#23I don't know much about this, but wouldn't the description of this imply you're stimulating the body to be in an a long-term situation that would be commonly viewed as unpleasant (inflamed, maybe nasal drainage, that type of thing) with the positive tradeoff that you get fewer actual infections?
Or worse. If it is so easy to activate, there must be an evolutionary reason why we don’t have it.
Maybe it would made the immune system age faster if it is "used" too much.
Re: Universal vaccine against respiratory infections and allergens
#24I don't know much about this, but wouldn't the description of this imply you're stimulating the body to be in an a long-term situation that would be commonly viewed as unpleasant (inflamed, maybe nasal drainage, that type of thing) with the positive tradeoff that you get fewer actual infections?
Me neither, but I got something similar from the abstract that I was about to ask, so adding it here: "Following infection, vaccinated mice mounted rapid pathogen-specific T cell and antibody responses and formed ectopic lymphoid structures in the lung." That latter term (ectopic lymphoid structure) comes up in connection with persistent inflammation where the immune system sets up camp near the problem point. Is thi…
These are pretty common, physiologic structures associated with infections. They can be just a handful of cells on a slide or be quite large, and I don't know what they found in these infections. I didn't read the original paper. The ectopic lymphoid structures go away after the infection resolves. It seems that the immune system has ways to set up mini lymph node architecture right by the site of infections, which is very sensible. The same process is going on in a more organized way in the draining lymph node in parallel. Research into these was really hot in the 2010s, but people don't seem to be as into them anymore (but my research has also transitioned to innate immunity from adaptive, so it's likely that I'm no longer in that universe).
In general, it doesn't surprise me that when you prime the innate immune system, the adaptive immune system works well. The problem is that pathogens have an incredible suite of tools ready to evade these mechanisms. The doses of the pathogens are typically insanely high too, which I do not think model natural infections well. Anyways, this is intriguing, so I'll take a look at the original paper one of these days. Vaccine research generally is so boring. It's like, we vaccinated, and it worked, or didn't, no mechanism.
Re: Universal vaccine against respiratory infections and allergens
#25[flagged]
Intranasal, no jabs
Re: Universal vaccine against respiratory infections and allergens
#26as someone with chronic nasal allergies, would this work for me?
Re: Universal vaccine against respiratory infections and allergens
#27Re: Universal vaccine against respiratory infections and allergens
#28Re: Universal vaccine against respiratory infections and allergens
#29Re: Universal vaccine against respiratory infections and allergens
#30I don't know much about this, but wouldn't the description of this imply you're stimulating the body to be in an a long-term situation that would be commonly viewed as unpleasant (inflamed, maybe nasal drainage, that type of thing) with the positive tradeoff that you get fewer actual infections?
Yep! But you are also a mouse who has limited venues in which to complain. I wonder if the vaccine causes inflammatory and other unpleasant responses when administered. If so, I wonder if those responses go away after the last dose, when the three months of protection begin. Here are the two paragraphs that I found interesting: > The new vaccine, for now known as GLA-3M-052-LS+OVA, mimics the T cell signals that dire…
> It also contains a harmless antigen, an egg protein called ovalbumin or OVA
Here's hoping the final product doesn't have a side-effect of inducing an allergy to the main component of egg-whites.
Although even if that happened... Would it only apply to the raw materials, as opposed to cooked products where the ovalbumin was denatured by heat?
Edit: No, wait! What about "safe to eat" cookie-dough, which uses heat-treated flour and pasteurized eggs as ingredients!? The might still have intact ovalbumin, and obviously I can't give it up.