Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Invention of DNA "page numbers" opens up possibilities for the bioeconomy

caltech.edu

Post reply on HN
Print view View original

21–30 of 102 posts

Re: Invention of DNA "page numbers" opens up possibilities for the bioeconomy

#22

Post by maxboone »

jurgenburgen wrote: post #6

The article mentions AI multiple times even though the invention appears to have nothing to do with AI. I guess it’s important to have it as a marketing buzzword. Sidewinder itself sounds neat. Has anyone dabbled in hobbyist genome editing and DNA synthesis or is this something that requires a huge pile of capital?

Probably AI in the sense of what Google DeepMind has been up to with the protein folding and other biological simulations, instead of the LLM variant of AI.

Re: Invention of DNA "page numbers" opens up possibilities for the bioeconomy

#23

Post by direwolf20 »

throwaway89201 wrote: post #21
nullbyte808 wrote: post #20

[flagged]

What's the source of the text? It seems to be either a copypasta from a journal article or LLM-generated (and not your own text).

LLM–generated summary. A human summary wouldn't specify the temperature used because it's irrelevant.

Re: Invention of DNA "page numbers" opens up possibilities for the bioeconomy

#24

Post by vee-kay »

melagonster wrote: post #18
vee-kay wrote: post #12

Earlier quoted context omitted.

Science has never been constrained by ethics. The same scientists who cry about ethics, have happily experimented on mice and guinea pigs in their labs, even if it causes the deaths or distress of those little sentient beings. Mutations/mutatives like Halo's Master Chief and Marvel's Super Soldier serum won't remain sci-fi for much longer, methinks.

And save human life at the same time? Experiments are not just about torturing animals; people spend a lot of time optimizing for experiment design.

[flagged]

Re: Invention of DNA "page numbers" opens up possibilities for the bioeconomy

#26

Post by wartywhoa23 »

unsupp0rted wrote: post #16
throwaway198846 wrote: post #15

Earlier quoted context omitted.

There is no way it is just "just". And we should start from simpler stuff like vitamin B12, C and D.

Everything is “just” eventually. Just tell your car to drive you to the airport. On the way just tell it to play that song you like.

Alas, one's happiness (as in genuine inner wellbeing, as opposed to the consumption-based external one) is no "just" matter, and never will be.

Re: Invention of DNA "page numbers" opens up possibilities for the bioeconomy

#28

Post by biophysboy »

Chemical modifications of DNA are so amazing, and underpin so much DNA related research and engineering. Illumina and Moderna would not exist without DNA mods. It’s very cool that the set of tools is expanding further!

“ Guided by the removable DNA page numbers, Sidewinder achieves an incredibly high fidelity in DNA construction with a measured misconnection rate of just one in one million, a four to five magnitude improvement over all prior techniques whose misconnection rates range from 1-in-10 to 1-in-30.”

I wonder if this is even a problem, since you could amplify the correct sequence with PCR afterward.

Re: Invention of DNA "page numbers" opens up possibilities for the bioeconomy

#29

Post by codesnik »

biophysboy wrote: post #28

Chemical modifications of DNA are so amazing, and underpin so much DNA related research and engineering. Illumina and Moderna would not exist without DNA mods. It’s very cool that the set of tools is expanding further! “ Guided by the removable DNA page numbers, Sidewinder achieves an incredibly high fidelity in DNA construction with a measured misconnection rate of just one in one million, a four to five magnitude i…

pcr amplifies all sequences, correct or wrong, no? and as I understand it, it works on short snippets the best.
Post reply on HN