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It's funny how many years of "X found to be effective in fighting cancer" stories have filtered through HN and then you never hear about it again. The research at treating mouse cancer has been making great strides--people cancer still has a long way to go though.
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This isn't quite as bad as the garden variety "in mice" studies: > The combination therapy also led to significant regression in genetically engineered mouse tumours and in human cancer tissues grown in lab mice, known as patient-derived tumour xenografts (PDX).
>"The combination therapy also led to significant regression in genetically engineered mouse tumours and in human cancer tissues grown in lab mice" Required XKCD: https://xkcd.com/1217/
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We really should be able to grow human bodies without a brain for testing purposes. It’s gruesome but realistically victimless at the end of the day.
Can you imagine the political/religious push-back were you to do that?! Growth of single human organs or organ tissue is easier, cheaper and less fraught with political peril.
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Because research on real humans and real diseases is exceptionally difficult. Clinical research is notoriously expensive, results are likely to differ from non-human (preclinical) models, and trials take forever to get started, gather enough data, and get a drug actually reviewed and approved. So even when everyone is excited by the preclinical data, there are so many barriers (both scientific and non-scientific) tha…
We really should be able to grow human bodies without a brain for testing purposes. It’s gruesome but realistically victimless at the end of the day.
IN MICE. (To be fair, also IN SOME OTHER BETTER MICE). https://jamesheathers.medium.com/in-mice-explained-77b61b598... (mostly a joke, but I'd be in favor of adding context to the HN headline if possible)
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>"The combination therapy also led to significant regression in genetically engineered mouse tumours and in human cancer tissues grown in lab mice" Required XKCD: https://xkcd.com/1217/
Is PDX considered to be illegitimate? Would be curious to know if prior studies that showed success with PDX methods ultimately resulted in useful therapeutics.
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Can you imagine the political/religious push-back were you to do that?! Growth of single human organs or organ tissue is easier, cheaper and less fraught with political peril.
As someone whose mother died to pancan, I could really care less on any of the brainwashed old farts in their churches or parliaments. None of that matters to me or the people suffering from cancers, it’s al Knut a selfish obstruction attaching religion to the research material
Unfortunately, they can vote.
I keep reading about these advancements in pancreatic cancer like early detection or possible treatments, but nothing ever seems to make it to daylight. Is there a reason why there's such disparity between this?
Source: https://www.uchealth.org/today/slow-but-steady-progress-impr...
Earlier quoted context omitted.
Because research on real humans and real diseases is exceptionally difficult. Clinical research is notoriously expensive, results are likely to differ from non-human (preclinical) models, and trials take forever to get started, gather enough data, and get a drug actually reviewed and approved. So even when everyone is excited by the preclinical data, there are so many barriers (both scientific and non-scientific) tha…
We really should be able to grow human bodies without a brain for testing purposes. It’s gruesome but realistically victimless at the end of the day.
IN MICE. (To be fair, also IN SOME OTHER BETTER MICE). https://jamesheathers.medium.com/in-mice-explained-77b61b598... (mostly a joke, but I'd be in favor of adding context to the HN headline if possible)