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The Molecular Basis of Long Covid Brain Fog

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Re: The Molecular Basis of Long Covid Brain Fog

#21

Post by colechristensen »

zdragnar wrote: post #15
Aurornis wrote: post #4

The headline overstates the findings. The researchers aren't saying that this is the underlying basis of COVID brain fog. They hypothesized that AMPA receptors might be involved. They compared Long COVID patients to controls and found a difference. This doesn't mean that AMPA receptors are the root cause of post-COVD brain fog, nor does it necessarily mean that drugs modulating AMPA receptors could reverse it. It onl…

It'd be nice to find out if there's any overlap with the "brain fog" from fibromyalgia. My college years would have been far less torturous if I could have lived without that, even if I still had to deal with the pain.

There's an assumption going around that idiopathic-ish conditions like fibromyalgia may be caused (or a subset of those with that diagnosis) by long-tail after effects of various infections, COVID-19 being one of many.

Re: The Molecular Basis of Long Covid Brain Fog

#23

Post by dekhn »

marstall wrote: post #2

Very cool. Surprising that having more AMPA receptors would lead to decreased cognition, as learning & memory is hypothesized to particularly involve processes that increase the number of in-position AMPA receptors.

In biology, cause and effect do not work the way they work in other fields. Effect is highly context-specific and things often work in the opposite direction than you might assume.

Re: The Molecular Basis of Long Covid Brain Fog

#24

Post by luxuryballs »

Take it how you will but I had brain fog and greatly diminished sense of smell for like 4 years and then for unrelated reasons decided to try some methylene blue as a supplement, started with a minuscule dose and within a week my sense of smell was fully restored and the brain fog was reduced to “normal levels”.

Re: The Molecular Basis of Long Covid Brain Fog

#25

Post by anon84873628 »

luxuryballs wrote: post #24

Take it how you will but I had brain fog and greatly diminished sense of smell for like 4 years and then for unrelated reasons decided to try some methylene blue as a supplement, started with a minuscule dose and within a week my sense of smell was fully restored and the brain fog was reduced to “normal levels”.

If we assume the hypothesis that long covid is caused by mitochondrial dysfunction, then there are plausible mechanisms by which MB could improve mitochondrial function (though a week sounds really fast?) Glad you're feeling better!

Re: The Molecular Basis of Long Covid Brain Fog

#26

Post by napoleongl »

all2 wrote: post #6

The biggest impact I've made on my brain fog (post COVID) is using nicotine. Even 2mg a day makes a big difference for me.

Interesting! I feel I’ve been kinda foggy in my head since I quit smoking a year or two before covid and it then got worse with the pandemic. And I’ve felt there’s been more effect from a night out with party smoking than just seeing an old friend. Might need to try my own home grown snuff when it’s done and not just give it away.

Re: The Molecular Basis of Long Covid Brain Fog

#29

Post by all2 »

napoleongl wrote: post #26
all2 wrote: post #6

The biggest impact I've made on my brain fog (post COVID) is using nicotine. Even 2mg a day makes a big difference for me.

Interesting! I feel I’ve been kinda foggy in my head since I quit smoking a year or two before covid and it then got worse with the pandemic. And I’ve felt there’s been more effect from a night out with party smoking than just seeing an old friend. Might need to try my own home grown snuff when it’s done and not just give it away.

Well aged leaf smells amazing. I've often thought about getting into pipe smoking, but my guess is its like coffee, it smells better than it tastes.

Re: The Molecular Basis of Long Covid Brain Fog

#30

Post by bigmattystyles »

all2 wrote: post #29
napoleongl wrote: post #26

Earlier quoted context omitted.

Interesting! I feel I’ve been kinda foggy in my head since I quit smoking a year or two before covid and it then got worse with the pandemic. And I’ve felt there’s been more effect from a night out with party smoking than just seeing an old friend. Might need to try my own home grown snuff when it’s done and not just give it away.

Well aged leaf smells amazing. I've often thought about getting into pipe smoking, but my guess is its like coffee, it smells better than it tastes.

If it's like coffee, you don't necessarily like it at first.
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