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FDA Approves drug to treat pain without opioid effects

nytimes.com

21–30 of 34 posts

Re: FDA Approves drug to treat pain without opioid effects

#21

There's no reason for this to be a NYT link. https://www.fda.gov/news-events/press-announcements/fda-appr...

There is at least one: in its quest to promote the agency they forgot to list the most basic issue that makes this approval noteworthy - addiction. Also there is no price and a bunch of other relevant info

Re: FDA Approves drug to treat pain without opioid effects

#22

Earlier quoted context omitted.

This is to treat acute pain, probably mostly post-op as alternative to opioids. At most you'll probably get a week's worth of pills from your doc post-op, and I would say the cost is worth it if it works better than NSAIDs and it's not addictive.

"It's worth it" isn't an answer to "drug prices are systematically inflated so many cannot afford them regardless.

That’s expensive today, yes, but it’s so hella expensive to bring a drug to market at all. I don’t mind a brand new drug costing $30/dose for a short term. That’s way more understandable than insulin or asthma inhalers going up 400%.

Re: FDA Approves drug to treat pain without opioid effects

#23
post #17

Earlier quoted context omitted.

If it means staying away from addiction, I'll pay it. Opiods would scare me if I ever needed that level of pain treatment.

They should, synthethic opioids are VERY enjoyable, VERY risky and SUPER addictive. I was on Oxy 24/7 for a month following surgery, went through hell.

I count myself as very, very lucky that opioids don’t do that for me at all. I’ve had strong prescriptions for various short-term needs over the years and they just make me a little sleepy. They don’t feel pleasant in any way, in the same way that Motrin doesn’t give me a warm fuzzy feeling either.

Re: FDA Approves drug to treat pain without opioid effects

#24
How does one give someone a placebo after surgery for clinical trials ? Wouldn’t that cause a lot of pain ? I know science and research and trials and all etc etc, but pain post surgery is quite a lot that placebo alone would be really bad for the patient.

Re: FDA Approves drug to treat pain without opioid effects

#25

Earlier quoted context omitted.

This is to treat acute pain, probably mostly post-op as alternative to opioids. At most you'll probably get a week's worth of pills from your doc post-op, and I would say the cost is worth it if it works better than NSAIDs and it's not addictive.

"It's worth it" isn't an answer to "drug prices are systematically inflated so many cannot afford them regardless.

In the context of post op painkillers, the cost of this pill is a drop in the bucket vs cost of hospitalization. The alternative to inflated drug prices is not having the drugs or, I guess, nationalizing the pharmaceutical companies? I don't think you'll get many takers for that plan tho.

Re: FDA Approves drug to treat pain without opioid effects

#26
post #3

There's no reason for this to be a NYT link. https://www.fda.gov/news-events/press-announcements/fda-appr...

> "There's no reason for this to be a NYT link." I respectfully disagree. The NYT paid the author, Gina Kolata, to research and write the story, which contains more details than just the press release alone, then used their platform to made the news widely available and thus helped people like me discover it. As cynical as one may be about the state of contemporary journalism, I'd say that short articles like this ar…

Given how late in the article it is mentioned that the drug was indistinguishable from placebo, this NYT article may well have been commissioned by Vertex.

[1] https://www.science.org/content/blog-post/pain-comes-territo...

Re: FDA Approves drug to treat pain without opioid effects

#27
post #3

There's no reason for this to be a NYT link. https://www.fda.gov/news-events/press-announcements/fda-appr...

> "There's no reason for this to be a NYT link." I respectfully disagree. The NYT paid the author, Gina Kolata, to research and write the story, which contains more details than just the press release alone, then used their platform to made the news widely available and thus helped people like me discover it. As cynical as one may be about the state of contemporary journalism, I'd say that short articles like this ar…

Middlemen like town criers and nowadays "journalists" were useful when distributing information en masse quickly was a tremendous if not next to impossible logistical challenge.

Today when anyone can get information straight from the source instantly, we do not need these middlemen. There is no reason for this to be an NYT link, nor any other middleman link.

The less players there are in the game of telephone the more accurate the information will be.

Re: FDA Approves drug to treat pain without opioid effects

#28
>>suzetrigine helped those with diabetic neuropathy, but was no better than placebo in those with pinched spinal nerves. (…) While analysts and researchers deemed the results disappointing in patients with pinched nerves in their spines, the company decided to proceed because there are no approved drugs for the painful condition, and because the drug is safe and “the mechanism of action is so clearly validated.”

“No one has ever helped these four million people,” he said. Aside from routinely burning the nerves, routine epidural injections, narcotics, or alcohol.

Extremely limited relief from expensive acupuncture, massage, TENS, stretching, etc.

Re: FDA Approves drug to treat pain without opioid effects

#29
post #27
post #3

Earlier quoted context omitted.

> "There's no reason for this to be a NYT link." I respectfully disagree. The NYT paid the author, Gina Kolata, to research and write the story, which contains more details than just the press release alone, then used their platform to made the news widely available and thus helped people like me discover it. As cynical as one may be about the state of contemporary journalism, I'd say that short articles like this ar…

Middlemen like town criers and nowadays "journalists" were useful when distributing information en masse quickly was a tremendous if not next to impossible logistical challenge. Today when anyone can get information straight from the source instantly, we do not need these middlemen. There is no reason for this to be an NYT link, nor any other middleman link. The less players there are in the game of telephone the mor…

Many news stories require domain expertise to understand.

If there's a news item involving Brazilian law, or a new Aluminum alloy, or a newly identified virus, then I likely wouldn't understand the raw data.

Middlemen are valuable to the extent either that they are knowledgeable about a topic, or have the resources to consult someone knowledgeable.

Re: FDA Approves drug to treat pain without opioid effects

#30
post #3

Earlier quoted context omitted.

> "There's no reason for this to be a NYT link." I respectfully disagree. The NYT paid the author, Gina Kolata, to research and write the story, which contains more details than just the press release alone, then used their platform to made the news widely available and thus helped people like me discover it. As cynical as one may be about the state of contemporary journalism, I'd say that short articles like this ar…

Given how late in the article it is mentioned that the drug was indistinguishable from placebo, this NYT article may well have been commissioned by Vertex. [1] https://www.science.org/content/blog-post/pain-comes-territo...

My impression is that the "indistinguishable from placebo" is only in reference to a study on people with Sciatica, but that a different study did show a statistically-significant effect on post-surgical pain.

$465 USD for a 15-day supply definitely pricey -- but options for people who weren't well-served by Purdue Pharma / OxyContin seem good, especially if the mechanism of action is different.

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