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Insomnia, but not lack of sleep, may hasten brain shrinkage: study

ucsf.edu

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Re: Insomnia, but not lack of sleep, may hasten brain shrinkage: study

#21

Post by graeme »

eagleinparadise wrote: post #3

I'm approaching midlife and noticing the quality of my sleep has declined. I can't sleep in anymore. Sometimes I'm waking up in the middle of the night occasionally and something I'm wide awake because I'm thinking about work or something like that. Very frustrating. Another reminder to try to pull myself away from the screens late at night.

Two low impact things to try are:

* A very small amount of melatonin. .300 to .500 mg.

* Breathe right strips, these increase airflow

Other health issues can also cause wakefulness.

Re: Insomnia, but not lack of sleep, may hasten brain shrinkage: study

#22

Post by pedalpete »

We work in the sleep space, and this isn't new.

I was at a conference last week, and for the first time heard about a study that suggested that the cycle is that a build up of amyloid, tau, lew bodies, and other metabolic waste in the brain reduces the slow-wave power which is responsible for clearing out this metabolic waste (via the glymphatic system).

This cycle is still not proven, but it was an interesting early hypothosis.

We've been developing slow-wave enhancement technology for the last 4 years which increases slow-wave activity, and the first 3 studies in Alzheimer's and MCI are now published. These are early studies with lots left to go.

Studies https://pmc.ncbi.nlm.nih.gov/articles/PMC10758173/ https://pubmed.ncbi.nlm.nih.gov/37593850/ https://www.proquest.com/intermediateredirectforezproxy

You can find out more about us at https://affectablesleep.com

We're raising an Angel round, and I'll be travelling through the US from Mid-Nov to early Dec. pete[a] domain if you want to learn more.

Re: Insomnia, but not lack of sleep, may hasten brain shrinkage: study

#23

Post by digging »

macrael wrote: post #10
orbifold wrote: post #2

> “Although the study found inadequate sleep duration was not an issue in brain atrophy in this study, we cannot say there is no association,” she said, noting that a previous CARDIA study showed that shorter sleep was associated with worse white matter integrity, indicating lower cognitive functioning. That quote seems to directly contradict the headline.

From the public results only[1] (I don't have a copy of the whole study) they studied the following things looking for correlation with brain decline: * short sleep duration * sleep quality * difficulty initiating sleep (DIS) * difficulty maintaining sleep (DMS) * early morning awakening (EMA) * daytime sleepiness They only found that the middle four were correlated. I don't know what exactly "sleep quality" is but t…

Sleep quality, if excluding DIS, DMS, EMA, usually will refer to things like apneas, nasal congestion, digestion, noise or light in the room, etc. Disturbances that don't wake the person but do tax the brain.

Re: Insomnia, but not lack of sleep, may hasten brain shrinkage: study

#25

Post by sarah_eu »

pedalpete wrote: post #22

We work in the sleep space, and this isn't new. I was at a conference last week, and for the first time heard about a study that suggested that the cycle is that a build up of amyloid, tau, lew bodies, and other metabolic waste in the brain reduces the slow-wave power which is responsible for clearing out this metabolic waste (via the glymphatic system). This cycle is still not proven, but it was an interesting early…

> We work in the sleep space

Is this another way of saying you work from bed?

Re: Insomnia, but not lack of sleep, may hasten brain shrinkage: study

#26

Post by Apocryphon »

My only hope is that now that we seemingly have a cure for obesity, as the population greys the next common non-cancer/heart disease ailment to tackle are brain issues that set in during old age. Maybe they'll have a pill that gets rid of all of the plaque or proteins or prions or whatever that sleep is for.

Re: Insomnia, but not lack of sleep, may hasten brain shrinkage: study

#30

Post by pedalpete »

sarah_eu wrote: post #25
pedalpete wrote: post #22

We work in the sleep space, and this isn't new. I was at a conference last week, and for the first time heard about a study that suggested that the cycle is that a build up of amyloid, tau, lew bodies, and other metabolic waste in the brain reduces the slow-wave power which is responsible for clearing out this metabolic waste (via the glymphatic system). This cycle is still not proven, but it was an interesting early…

> We work in the sleep space Is this another way of saying you work from bed?

What can I say? I'm a hard worker. ;)
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