Psilocybin saved my life. I'm no longer suicidal, I'm no longer a practicing alcoholic, and outside of a few things here and there, I'm generally at peace with my life. I cannot express how grateful I am for psilocybin.
Psilocybin bests SSRI for major depression in first long-term comparison
21–30 of 397 posts
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#22Funny, psilocybin has been largely detrimental to the mental health of everyone I know.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#23I wonder how much of an uphill battle it will be to get psilocybin approved for therapeutic use compared to synthetic psilocybin analogues that are being trialed right now. Psilocybin can't be patented and it's already scheduled as a narcotic everywhere.
Geneva is home to the only Swiss hospital offering psychedelic-assisted therapy. [0]
Also, Peter Gasser, a Swiss therapist acquainted with LSD during the 1988-1993 window, was granted approval to carry out the first controlled study of LSD-assisted psychotherapy in more than 40 years. [1]
[0] https://www.swissinfo.ch/eng/science/can-psychedelics-therap...
[1] https://theswisstimes.ch/lsd-and-magic-mushrooms-how-switzer...
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#24It’s a neat study. I don’t know how you account for the intense placebo effect of a psychedelic experience for six hours though. We know that traditional antidepressants may work through this method already where you feel “different” and fix yourself. Trials with an active placebo often have results very similar to antidepressants. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ I guess maybe it doesn’t even ma…
This might not be ethical, but given a psychedelic naive population, I wonder if the control could be given a non-serotonergic psychedelic such as salvinorin A. There would definitely be a noticeable effect, but for someone who hasn't studied the effects of psilocybin, they may not realize it. The downside is that in order to keep the duration similar, you'd probably have to administer the salvinorin using an IV drip, and a six hour salvia trip could quite possibly be too traumatic.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#25Psilocybin saved my life. I'm no longer suicidal, I'm no longer a practicing alcoholic, and outside of a few things here and there, I'm generally at peace with my life. I cannot express how grateful I am for psilocybin.
Is it something that you still take here and there or was it a time limited therapy ?
Congrats on finding a cure for your ailments
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#26I think a major criticism of how this study is designed is that it is not truly "blinded". I doubt many of the participants were unsure if they received psilocybin vs escitalopram. That being said, there are a number of studies that suggest this is an effective treatment, so I hope this can become more available to those who need it. However, for treatment resistant depression (especially with a catatonia component),…
How would you effectively blind a study on a drug with such obvious "side effects"?
I can see such unreasonable objections being used to prevent it's approval though.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#27It’s a neat study. I don’t know how you account for the intense placebo effect of a psychedelic experience for six hours though. We know that traditional antidepressants may work through this method already where you feel “different” and fix yourself. Trials with an active placebo often have results very similar to antidepressants. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ I guess maybe it doesn’t even ma…
This might not be ethical, but given a psychedelic naive population, I wonder if the control could be given a non-serotonergic psychedelic such as salvinorin A. There would definitely be a noticeable effect, but for someone who hasn't studied the effects of psilocybin, they may not realize it. The downside is that in order to keep the duration similar, you'd probably have to administer the salvinorin using an IV drip…
It might be nice to also have a non-psychedelic non-sari as well. Right now a patient could use whether they tripped or not to determine exactly which treatment they received. But if you had the full 2x2 design of {drug has trip, drug has no trip} x {drug is supposedly therapeutic, drug is non therapeutic} the existence of a trip wouldn’t reveal their exact treatment
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#28Funny, psilocybin has been largely detrimental to the mental health of everyone I know.
In what way were they using it? In what dosages? Was it pharmaceutically pure or bought from some dude?
Overdosing on SSRIs or using them haphazardly could be pretty detrimental too.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#29I wonder how much of an uphill battle it will be to get psilocybin approved for therapeutic use compared to synthetic psilocybin analogues that are being trialed right now. Psilocybin can't be patented and it's already scheduled as a narcotic everywhere.
I doubt about everywhere, as shrooms are sold in shop around here.
Where is here?
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#30I wonder how much of an uphill battle it will be to get psilocybin approved for therapeutic use compared to synthetic psilocybin analogues that are being trialed right now. Psilocybin can't be patented and it's already scheduled as a narcotic everywhere.
The 2018 Hemp Farm bill gave the balls back to the citizens that the 2013 Analag act neutered.
Seeing mushroom extracts with all the alkaloids included besides psilocybin at gas stations may be a temporary point of stability until I can go to the "21+" store in 2030 to get my preferred arylcyclohexylamine and phenylethylamine variant.