This news should be irrelevant to anyone not undergoing this specific type of chemotherapy.
Lactate helps cancer cells resist chemotherapy
21–26 of 26 posts
Re: Lactate helps cancer cells resist chemotherapy
#22Is there a potential for beta-alanine/L-Carnosine to help here?
Re: Lactate helps cancer cells resist chemotherapy
#23Earlier quoted context omitted.
Lactate accumulates in the body only during a high intensity exercise, which generates lactate faster than it can be consumed by oxidation (like a sprint for up to 400 m). When the intensity of an exercise is low enough that you could sustain it for much more than a few minutes continuously, there should be no increased amount of lactate in the body.
I want to expand a bit on your last statement. It is generally true but there is some important nuance I'd like to add. There may be some increased lactate temporarily but it will be minimal for aerobic exercise. It takes at least 2 minutes from a resting state for the body to reach VdotO2max. This means that even during aerobic exercise, you will be using at least some anaerobic energy production initially if you we…
Guys, guys. It's not about exercise. Cancer makes lactate independent of exercise. Exercise, in lack of oxygen, also makes lactate.
Here's the thing with cancer (1) sometimes it actually does lack oxygen, because it grows faster than blood vessels, so may prefer lactate creation, known as "fermentation" (yes, like beer which ferments sugar to alcohol, but humans ferment sugar into lactate). So the whole body may be bedridden, not exercising, but a little part of it is not getting oxygen. (2) EVEN IF there is oxygen available to the cancer cell, they have been shown to, EVEN THOUGH there is oxygen there, they still proceed through fermentation and produce lactate. And it's not well known WHY cancer cells do this. This paper suggests that it's a chemo resistance mechanism. Other thoughts have been that it simply pushes through more physical carbon atoms which help make more cancer faster.... this concept of "why does the cancer ferment even though oxygen is readily available" is known as "The Warburg Hypothesis"
Because with oxygen 30x more ATP is produced. Why would cancer seek the vastly more inefficient energy production pathway, the insinct is that cancer would be hyperefficient at being canerous.
Dunning-Kruger energy here...
Re: Lactate helps cancer cells resist chemotherapy
#24Earlier quoted context omitted.
Has this been incorporated into protocols or is this still fringe?
That's entirely the wrong set of questions to ask. It is scientifically validated which is what matters as far as the truth is concerned.
I think you’re going to find a lot of family of cancer victims who have a few choice, withering words for you.
Consider this #1. Your response is ghoulish.
Re: Lactate helps cancer cells resist chemotherapy
#25Earlier quoted context omitted.
That's entirely the wrong set of questions to ask. It is scientifically validated which is what matters as far as the truth is concerned.
I think you’re going to find a lot of family of cancer victims who have a few choice, withering words for you. Consider this #1. Your response is ghoulish.
On the contrary, it is willfully ignoring science that is ghoulish. Most people don't have the moral fortitude to fast even if they wanted to, so fasting is never going to get incorporated into any "protocol".
Re: Lactate helps cancer cells resist chemotherapy
#26Earlier quoted context omitted.
I want to expand a bit on your last statement. It is generally true but there is some important nuance I'd like to add. There may be some increased lactate temporarily but it will be minimal for aerobic exercise. It takes at least 2 minutes from a resting state for the body to reach VdotO2max. This means that even during aerobic exercise, you will be using at least some anaerobic energy production initially if you we…
Guys, guys. It's not about exercise. Cancer makes lactate independent of exercise . Exercise, in lack of oxygen, also makes lactate. Here's the thing with cancer (1) sometimes it actually does lack oxygen, because it grows faster than blood vessels, so may prefer lactate creation, known as "fermentation" (yes, like beer which ferments sugar to alcohol, but humans ferment sugar into lactate). So the whole body may be…
Hi, I didn't comment on the cancer part. The discussion elsewhere in this thread connecting this to exercise seems specious to me. I was just trying to put in a good reminder to warm up before you exercise. I appreciate your clarification nonetheless.