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Tripping on Xenon Gas (2023)

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Re: Tripping on Xenon Gas (2023)

#21
The Xenon episode of Hamilton's Pharmacopeia is one of the very best episodes of that series, I don't know the best way to find it on streaming currently, it was available I believe on Netflix (or maybe it was Hulu?): https://www.vicetv.com/en_us/video/xenon-the-perfect-anesthe...

The full episode takes very disturbing twists and turns, worth a watch.

Re: Tripping on Xenon Gas (2023)

#22
post #11
post #7

Earlier quoted context omitted.

No, xenon is a NMDA antagonist meaning it has dissociative/anaesthetic effects like ketamine or nitrous oxide. TFA talks about the effects coming on "within seconds" of inhalation, so it is clearly not just hypoxia which takes tens of seconds or minutes to manifest.

How does it do that without forming chemical compounds? Is it like a catalyst for another reaction or something?

It will still react through (weaker) non covalent forces, like van der Waals force.

Re: Tripping on Xenon Gas (2023)

#23
post #4

Earlier quoted context omitted.

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Reading the intro I was expecting g something totally impossibly expensive but > Xenon is extremely expensive — a single 30-second dose costs between $50 and $80 I mean, it just seems like a normal rip off, not even that exclusive.

Krypton is cheaper, and not yet banned in international competition. Xenon and argon are banned. There is no test for any of these.

Re: Tripping on Xenon Gas (2023)

#24

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I think this is an unnecessarily polarized admonition. Alcohol is arguably more than possibly-lethal, but many people exercise a reasonable risk calculus that allows them to enjoy it, and even enjoy it to a low level to moderate excess (on occasion), and that doesn't necessarily indicate pathological drug abuse.

An unusual medically-safe (in medical contexts) anesthetic generating curiosity about recreational effects and safe use is not unreasonable, and having that curiosity certainly doesn't imply that someone is "not ok!"

I'm not saying that Xenon isn't exotic; it likely takes someone with a strong background in less-dangerous inhalant usage (and deep pockets) to use it safely. But there are plenty of exotic substances that people use safely and sanely throughout the world, and telling people off for having interest drawn from a (reasonably balanced, I would say) source ain't the business.

Re: Tripping on Xenon Gas (2023)

#25

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I'm not a xenon user, but I completely disagree with what you've said here. What is your point, that because xenon is hard to make it's an insane person's drug? You're implying a huge level of risk but TFA outright states that xenon is incredibly safe, which can't be said for ingesting carcinogens from combusted cannabis, or from drinking alcohol which can kill you in a single night pretty easily. Are you saying TFA is lying about the chemical safety of inhaling xenon?

Re: Tripping on Xenon Gas (2023)

#26
post #8
post #3

Wouldn't it be the same as breathing any other nonreactive gas? Isn't this just symptoms of hypoxia?

Clearly the symptoms aren't the same as just holding your breath, which makes me think that it is not, in fact, completely nonreactive. (But I'm a total noob to biochemistry.) Similar to Nitrous Oxide, which definitely has a powerful psychedelic effect and is not at all simply hypoxia.

I wouldn’t call nitrous oxide “psychedelic” although it is certainly psychoactive.

Re: Tripping on Xenon Gas (2023)

#27
post #11
post #7

Earlier quoted context omitted.

No, xenon is a NMDA antagonist meaning it has dissociative/anaesthetic effects like ketamine or nitrous oxide. TFA talks about the effects coming on "within seconds" of inhalation, so it is clearly not just hypoxia which takes tens of seconds or minutes to manifest.

How does it do that without forming chemical compounds? Is it like a catalyst for another reaction or something?

Reactions don't need to happen, the magnesium ion is a single atom that interacts with the NMDA receptor to block it at specific potentials. When the postsynaptic neuron gets enough input at a synapse, there is enough change in the charge inside the cell where it allows the Mg2+ ion to be displaced from the pore to allow cations to pass through

Our cells use single atoms, usually in the form of charged ions, on a regular basis and we would not survive without them

Re: Tripping on Xenon Gas (2023)

#28
post #8
post #3

Wouldn't it be the same as breathing any other nonreactive gas? Isn't this just symptoms of hypoxia?

Clearly the symptoms aren't the same as just holding your breath, which makes me think that it is not, in fact, completely nonreactive. (But I'm a total noob to biochemistry.) Similar to Nitrous Oxide, which definitely has a powerful psychedelic effect and is not at all simply hypoxia.

Xenon gas is nonreactive, but it can dissolve into your blood and influence the very sensitive chemistry of your brain.

Re: Tripping on Xenon Gas (2023)

#29
post #17

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Couldn't you say the same about any extreme activity (like going to the moon or base jumping or extreme stuntmen etc)? Some people seek out risk because it makes life worth living. Life is finite anyways so even if you are very careful you'll end up dead just like the rest of us.

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Re: Tripping on Xenon Gas (2023)

#30
post #16

> Xenon is unique among psychedelic drugs because it’s a pure element. It leaves the body exactly as it entered, completely unchanged. I very doubt it is true. The article poorly hand waves later that a brain without oxygen will starve. I bet shooting this crap for some short term high will burn your brain cells, even if mixed with oxygen.

That's absolutely not true. It is already used in medical practice and mixing with oxygen, similar to how laughing gas is used, prevents hypoxia. These things are easy to google if you actually care to look
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