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Gene therapy restores hearing to children with inherited deafness

cosmosmagazine.com

21–30 of 231 posts

Re: Gene therapy restores hearing to children with inherited deafness

#21
I’m curious about the effect on the deaf community. I understand there’s resistance to “fixing” deafness as some consider it a component of their culture and community, not unlike queer people and the attempts to “fix” them.

https://en.wikipedia.org/wiki/Cochlear_implant#Criticism_and...

Re: Gene therapy restores hearing to children with inherited deafness

#23

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

Apart from the other points people have made, it's worth noting that these days parents can avoid having children with inherited genetic disorders through IVF. While there will always be a component of spontaneous mutations resulting in genetic disease, we may approach within a couple of generations a state where most inherited disorders actually disappear or reduce to vastly lower prevalence over time.

Re: Gene therapy restores hearing to children with inherited deafness

#24
post #2

This stuff seems miraculous. > "Through minimally invasive surgery, Shu injected adeno-associated virus (AAV) engineered to carry and deliver functioning copies of the human OTOF transgene, into the children’s inner ears. " Can't read that and not get curious, excited, for the future. Congratulations to all those involved in the research and thanks to all who contributed to it - including all taxpayers if public fund…

I can’t wait for a geneCAD where we for example, design wings for a human body and then it works out the rest and generates a CRISPR based AAV that you can inject yourself with. True race and sex changes too. Hopefully in the next 50 years but that’s wishful thinking.

it’s happening! i just finished something that assists in “CRISPR Design” and helps gene editors.

Re: Gene therapy restores hearing to children with inherited deafness

#26

Earlier quoted context omitted.

I can’t wait for a geneCAD where we for example, design wings for a human body and then it works out the rest and generates a CRISPR based AAV that you can inject yourself with. True race and sex changes too. Hopefully in the next 50 years but that’s wishful thinking.

There are potential serious downsides if these inserted genes end up on a different chromosome than normal and become carried by gametes to offspring who may suffer from overexpression.

[dead]

Re: Gene therapy restores hearing to children with inherited deafness

#27

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

ah, an eugenicist. and yet, if i stated that eugenicists should be eliminated from the gene pool, you'd be outraged.

Re: Gene therapy restores hearing to children with inherited deafness

#28

I’m curious about the effect on the deaf community. I understand there’s resistance to “fixing” deafness as some consider it a component of their culture and community, not unlike queer people and the attempts to “fix” them. https://en.wikipedia.org/wiki/Cochlear_implant#Criticism_and...

There is a fascinating documentary about this, but I cannot recall its name. One segment talks about a form of sign that represents sound, so that the child learns their family’s language (rather than sign language, which is another language entirely). It is very unpopular in the deaf community despite its advantages for daily life.

Re: Gene therapy restores hearing to children with inherited deafness

#29
post #2

This stuff seems miraculous. > "Through minimally invasive surgery, Shu injected adeno-associated virus (AAV) engineered to carry and deliver functioning copies of the human OTOF transgene, into the children’s inner ears. " Can't read that and not get curious, excited, for the future. Congratulations to all those involved in the research and thanks to all who contributed to it - including all taxpayers if public fund…

I can’t wait for a geneCAD where we for example, design wings for a human body and then it works out the rest and generates a CRISPR based AAV that you can inject yourself with. True race and sex changes too. Hopefully in the next 50 years but that’s wishful thinking.

Taking it seriously for a moment, that still seems outlandish even in a sci-fi scenario. The amount of changes that would be necessary to the body for a human to achieve autonomous powered flight would be substantial.

Given our overall density, we would need enormous wings and musculature. Consider that the heaviest flying birds alive today weigh maybe 40lbs and have a wingspan of 8ft or so. If we naively extrapolate that linearly then an adult weighing 160lbs would need a 32ft wingspan.

There were flying pterosaurs that weighed much more than the heaviest flying birds today, but they were also the size of small planes and it’s a bit of a debate how well they even flew. They may have struggled to even take flight.

So injecting yourself with some designer DNA isn’t just going to make you grow wings, it would have to completely transform you into a completely different creature, simply due to the physics of flight.

Additionally, you need not only to be able to fly, but your body needs to function well enough to stay in this new state. You would also likely need an enormous caloric intake to support the massive new growth, or it would take a very, very long time.

It wouldn’t be designing wings for a human, it would be designing a be creature based on a human but not human at all, really. Call me shortsighted but I don’t really see how that will ever be possible.

Re: Gene therapy restores hearing to children with inherited deafness

#30

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

I’m sure you have some undesirable genes too, whether you’re aware of it or not.
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