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FDA approves first medication to reduce allergic reactions to multiple foods

fda.gov

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Re: FDA approves first medication to reduce allergic reactions to multiple foods

#21

Post by spondylosaurus »

monero-xmr wrote: post #18
gnicholas wrote: post #7

From what I read of this, it's very expensive (thousands/mo), requires at least monthly injections at a facility, has a risk of anaphylaxis (so the injections can't be done at home), doesn't eliminate the risk of allergic reactions, and has no off-ramp (so you have to take it forever). Not exactly a silver bullet... My first thought was that it could be good for kids, who are less good at checking for trace amounts o…

It’s annoying to read “so and so new drug costs too much.” Creating new drugs is absurdly expensive. Most new drugs target small population groups, which is why treatments do not already exist - the low hanging fruit with large market potential gets targeted first. Just be happy a flag is planted in the ground. New drugs will be created from this that are different enough to avoid the patent, and new research will en…

To be fair, Xolair isn't a new drug at all (it's been around for 20-ish years, I think?), this is just a new thing that it's approved for.

I'm not sure why a generic hasn't hit the market yet, though. Maybe there's not enough demand to make it lucrative enough, unlike the golden child adalimumab...

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#23

Post by petesergeant »

heywire wrote: post #4

Somewhat related, I am allergic to an assortment of fruits and vegetables (celery, carrots, watermelon, cantaloupe, bananas, etc…). Most of my food allergies are related to Oral Allergy Syndrome. I’ve been taking Flonase now for more than a year for sinus congestion from allergies, and my food allergies have all but gone away. It has been great being able to enjoy these foods without my mouth, throat, and ears itchin…

I've been taking fluticasone propionate (which Flonase is) as a nasal spray nightly, and it's completely stopped me snoring and cured sleep apnea that previously I needed a CPAP machine for. Great stuff.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#24

Post by monero-xmr »

spondylosaurus wrote: post #21
monero-xmr wrote: post #18

Earlier quoted context omitted.

It’s annoying to read “so and so new drug costs too much.” Creating new drugs is absurdly expensive. Most new drugs target small population groups, which is why treatments do not already exist - the low hanging fruit with large market potential gets targeted first. Just be happy a flag is planted in the ground. New drugs will be created from this that are different enough to avoid the patent, and new research will en…

To be fair, Xolair isn't a new drug at all (it's been around for 20-ish years, I think?), this is just a new thing that it's approved for. I'm not sure why a generic hasn't hit the market yet, though. Maybe there's not enough demand to make it lucrative enough, unlike the golden child adalimumab...

I wasn’t aware of this, thanks for clarification. I will leave my comment as-is because it’s my take on the general “we need to ban price gouging on new drugs!” sentiment.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#25

Post by [deleted] »

gnicholas wrote: post #7

From what I read of this, it's very expensive (thousands/mo), requires at least monthly injections at a facility, has a risk of anaphylaxis (so the injections can't be done at home), doesn't eliminate the risk of allergic reactions, and has no off-ramp (so you have to take it forever). Not exactly a silver bullet... My first thought was that it could be good for kids, who are less good at checking for trace amounts o…

[deleted]

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#27

Post by Madmallard »

Very expensive

Not a great side effect profile

Not even very effective

Yup sounds like medicine in the 21st century. I think we're going to cull ourselves as a species because we're not at all aligned with doing things that actually make people healthier, unless that also happens to make good money.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#28

Post by lettergram »

modeless wrote: post #8

I've been following this closely. I'm most interested in Xolair (and another one, Dupixent) as a way to make oral immunotherapy (OIT) safer and more effective. Xolair can reduce reactions for sure, but it can't get people to the point where they can actually eat normal serving sizes of their food allergens. Oral immunotherapy can do that. And Xolair is a twice monthly injection. Nobody wants to do that for the rest o…

I’ve been on Dupixent and have a large number of allergies.

100% helped eczema. I used to have it to the point all my fingers were split in 5-8 places and I’d rate the pain scale at 8-9/10 (10 being arm cut off). I used to get blisters under the skin that’d combine and basically just peal off the skin - https://www.mayoclinic.org/diseases-conditions/dyshidrosis/s...

Anyway, Dupixent made it entirely go away. I also found my allergies did improve (suddenly wasn’t allergic to dogs). That said, it did have a side effect of severely drying out my eyes and I’ll get weird rashes on my face periodically and it requires injections 2x per month. That said, I can use my hands now, frankly I can think too. Pain is gone, and idc about the symptoms.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#29

Post by jwstanly »

Exciting to see FDA approval here. Hopefully next is FDA approval for programs like TIP (https://foodallergyinstitute.com/food-allergy-treatment/). I'm a TIP grad, its life changing to be cured versus still avoiding your allergens and only having reduced anaphylaxis risk.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#30

Post by a_gnostic »

spondylosaurus wrote: post #21
monero-xmr wrote: post #18

Earlier quoted context omitted.

It’s annoying to read “so and so new drug costs too much.” Creating new drugs is absurdly expensive. Most new drugs target small population groups, which is why treatments do not already exist - the low hanging fruit with large market potential gets targeted first. Just be happy a flag is planted in the ground. New drugs will be created from this that are different enough to avoid the patent, and new research will en…

To be fair, Xolair isn't a new drug at all (it's been around for 20-ish years, I think?), this is just a new thing that it's approved for. I'm not sure why a generic hasn't hit the market yet, though. Maybe there's not enough demand to make it lucrative enough, unlike the golden child adalimumab...

What's the Mexican name? Asking for a Mexican friend.
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