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Novel drug could protect brains from damage after repeat concussions

medicalxpress.com

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Re: Novel drug could protect brains from damage after repeat concussions

#21

Post by krisoft »

anonzzzies wrote: post #10
bdcravens wrote: post #3

Earlier quoted context omitted.

Perhaps, but many sports (such as football and American football) are far too popular to end anytime soon. Additionally, it may be given as a precaution after a first concussion (car wreck, for example), even if that person is unlikely to be "banged on the head everyday"

Any stats on this? Sports (that cause these injuries) are a choice/entertainment and people should pay for playing (like you should pay if you are obese, smoke or drink), but how much of this are actual accidents (cars, normal bike riding, work, army)?

> people should pay for playing

I’m sorry, what? There are two ways I can interpret what you wrote. “Should pay” as in the people who play sports should buy their own concussion medicine. Which is okay I guess? But nobody talked about financing.

Which makes me think you mean “should pay” as in people who choose to partake in sports should suffer harm (as in pay the metaphorical “price”). Is that how you mean it? Because that sounds extremely cruel and twisted morality. There is nothing “should” about that. That makes it sound as if these people deserve the harm even if we could prevent it.

Re: Novel drug could protect brains from damage after repeat concussions

#22

Post by euroderf »

therein wrote: post #15
Codesleuth wrote: post #11

> A 54-g metal (tungsten) bolt was used to deliver an impact to the dorsal aspect of the skull, resulting in a rotational acceleration of the head through the Kimwipe. Mice underwent seven repetitive less-than-mild injuries (rlmTBI, 24-inch height; W/5 mm flat) OR repetitive mild injuries (rmTBI, 36-inch height; W/5 mm flat) in 9 days. This seems very cruel, even in the face of progress. The price that animals pay fo…

I'd take it further, in my opinion, it is essentially unjustifiable in a deeply karmic way. I genuinely think that I would be able to work on a weapons guidance system and even know that it has been used to target a military vehicle without feeling much guilt but performing the kind of work you have quoted on animals would make me stop and think. And just stop. It is not worth the progress. Not worth the credits, the…

A friend in biology spent many work days doing little else than putting mice into a guillotine. Chopping off their little heads to get a snapshot of their brain chemistry after a dose of something.

It definitely messed her up, and she was quite aware of the toll it was taking.

Re: Novel drug could protect brains from damage after repeat concussions

#23

Post by ntlve »

stavros wrote: post #20
xlii wrote: post #12

Earlier quoted context omitted.

As far as I know there aren’t any sports which are completely safe and without side effects. Sport can ruin your joints (eg. running), spine (eg. weightlifting) and cause plethora of other health issues (anecdotally I know many people who got serious injuries from while leisurely playing team games). Usually there’s net gain from those activities, and what sport one practices vastly depends on preference and I’d rath…

Swimming?

Possibly not: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869851/

Re: Novel drug could protect brains from damage after repeat concussions

#24

Post by rob74 »

xlii wrote: post #12
cat_plus_plus wrote: post #2

If you end up taking a drug because someone bangs you on your head everyday, it's good that it's there, but you might also want to put a stop to that.

As far as I know there aren’t any sports which are completely safe and without side effects. Sport can ruin your joints (eg. running), spine (eg. weightlifting) and cause plethora of other health issues (anecdotally I know many people who got serious injuries from while leisurely playing team games). Usually there’s net gain from those activities, and what sport one practices vastly depends on preference and I’d rath…

Cycling is better for the joints than running. Unfortunately, bicycles are so damned effective that you have to cycle for a lot longer to burn the same amount of calories as when running...

Re: Novel drug could protect brains from damage after repeat concussions

#25

Post by anonzzzies »

krisoft wrote: post #21
anonzzzies wrote: post #10

Earlier quoted context omitted.

Any stats on this? Sports (that cause these injuries) are a choice/entertainment and people should pay for playing (like you should pay if you are obese, smoke or drink), but how much of this are actual accidents (cars, normal bike riding, work, army)?

> people should pay for playing I’m sorry, what? There are two ways I can interpret what you wrote. “Should pay” as in the people who play sports should buy their own concussion medicine. Which is okay I guess? But nobody talked about financing. Which makes me think you mean “should pay” as in people who choose to partake in sports should suffer harm (as in pay the metaphorical “price”). Is that how you mean it? Beca…

No that's not how I mean it, sorry. I mean if you put yourself in danger, society shouldn't necessarily pay. Sports is healthy if it's not a sport that endangers your body and that should be rewarded; sports that are proven to give you multiple injuries (concussions etc) are not very different from bad addictions. It's your choice/responsibility, not 'ours'.

But no I definitely didn't mean the tail end. Sorry if you read that into it; I would never say that.

Re: Novel drug could protect brains from damage after repeat concussions

#26

Post by refurb »

Codesleuth wrote: post #11

> A 54-g metal (tungsten) bolt was used to deliver an impact to the dorsal aspect of the skull, resulting in a rotational acceleration of the head through the Kimwipe. Mice underwent seven repetitive less-than-mild injuries (rlmTBI, 24-inch height; W/5 mm flat) OR repetitive mild injuries (rmTBI, 36-inch height; W/5 mm flat) in 9 days. This seems very cruel, even in the face of progress. The price that animals pay fo…

These animals are anesthetized.

”The mice were anesthetized for 5 min using 4% isoflurane in a 70:30 mixture of air:oxygen”

The regulations around animal testing are strict. You need to reduce all suffering to the maximum extebt possible.

You can apply for research where suffering occurs, if justified by the research (say anesthetic or analgesics interfere) but good luck getting it approved. You’ll be told “come back with a better approach”.

Re: Novel drug could protect brains from damage after repeat concussions

#27

Post by refurb »

gnicholas wrote: post #6
cat_plus_plus wrote: post #2

If you end up taking a drug because someone bangs you on your head everyday, it's good that it's there, but you might also want to put a stop to that.

Could be useful for soldiers, who may be subject to concussions on an unfortunately regular basis.

Much of the TBI research is funded by the DOD.

Re: Novel drug could protect brains from damage after repeat concussions

#29

Post by doublerabbit »

refurb wrote: post #26
Codesleuth wrote: post #11

> A 54-g metal (tungsten) bolt was used to deliver an impact to the dorsal aspect of the skull, resulting in a rotational acceleration of the head through the Kimwipe. Mice underwent seven repetitive less-than-mild injuries (rlmTBI, 24-inch height; W/5 mm flat) OR repetitive mild injuries (rmTBI, 36-inch height; W/5 mm flat) in 9 days. This seems very cruel, even in the face of progress. The price that animals pay fo…

These animals are anesthetized. ”The mice were anesthetized for 5 min using 4% isoflurane in a 70:30 mixture of air:oxygen” The regulations around animal testing are strict. You need to reduce all suffering to the maximum extebt possible. You can apply for research where suffering occurs, if justified by the research (say anesthetic or analgesics interfere) but good luck getting it approved. You’ll be told “come back…

And that makes it all okay? Still insanely cruel.

Would you volunteer to be anaesthetised and then have your head bashed in multiple times?

No? Why should animals.

Re: Novel drug could protect brains from damage after repeat concussions

#30

Post by PeterStuer »

xlii wrote: post #12
cat_plus_plus wrote: post #2

If you end up taking a drug because someone bangs you on your head everyday, it's good that it's there, but you might also want to put a stop to that.

As far as I know there aren’t any sports which are completely safe and without side effects. Sport can ruin your joints (eg. running), spine (eg. weightlifting) and cause plethora of other health issues (anecdotally I know many people who got serious injuries from while leisurely playing team games). Usually there’s net gain from those activities, and what sport one practices vastly depends on preference and I’d rath…

It might also be we'll greenlight sports that have more head impact. There is definetly an audience for it, and now it will be just as (un)safe as before.
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