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Mid-old cells are a potential target for anti-aging interventions in the elderly

nature.com

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Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#21

Post by airtonix »

jbstack wrote: post #17
radu_floricica wrote: post #16

Earlier quoted context omitted.

I'll never understand this particular mindset. I mean, I can get _some_ of the fallacies involved. Pure envy. Scope insensitivity. But it just doesn't explain it for me. People buying high end audio gear have disposable income and spend obscene amounts of money on their hobby, and yet they get at most mild ridicule. Old people wanting _not to die_ get hate. How do people even get here?

It's also shortsighted. You might never develop a taste for high end audio gear. But you certainly will age and die. Unlike many things it's a problem that affects every single one of us.

[dead]

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#22

Post by anovikov »

yanis_t wrote: post #20
morbicer wrote: post #4

[flagged]

Should we also get rid of some of the young people if they are grumpy? Are you sure 80 years is enough, maybe it's 30?

This. Young people are way too grumpy these days, more than the old farts i know, who tend to enjoy their lives overall and are nice to others.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#23

Post by gumby »

block_dagger wrote: post #9
defenestration wrote: post #8

Earlier quoted context omitted.

There is a social issue around death that is quite complex. A wish for a sudden peaceful death at a certain old age is not an easy one. Family, doctors, society and laws should be aligned on this. Right now the norm (at least in the Netherlands) is too keep a person alive as long as reasonably possible.

My mother is going through a kind of hell created by laws that prevent her from ending her life as she wishes. I hope dignity around death for the elderly becomes more of a public issue.

My grandmother starved herself to death at 97 because any other approach was then illegal (for anyone else to facilitate). All her friends were dead and she didn’t really like old people. As her vision and hearing started to deteriorate she figured it was not worth waiting for a letter from the Queen.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#24

Post by gumby »

sasaf5 wrote: post #14
shiroiuma wrote: post #10

Earlier quoted context omitted.

Exactly right. This is a total waste of time, and this effort should be spent on something more productive and useful for humanity, such as improving advertising technologies and preventing people from blocking or ignoring advertisements.

As someone who develops for a large tech company and would like to join the effort to defeat aging, where should I start?

Go back to school and get a PhD in biochemistry, and if you’re up for it an MD in gerontology.

Not joking.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#25

Post by greatpatton »

heisenbit wrote: post #7

[flagged]

I don't know but as someone who is currently taken in between my kids needing a lot of support and my mother who is declining and requiring a lot of help (+ jobs), I would welcome any progress regarding aging to make people as fit as possible as currently my life is a bit difficult.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#28

Post by johnnyworker »

morbicer wrote: post #4

[flagged]

People don't like hearing it, but if you can't make peace with your mortality in 80 years, you won't manage it in 800 either. And you (whoever is reading is) isn't actually that special that you should go on forever, instead of new life coming into the world. It would be a bigger loss for you to stay, than for you to pass on, because of the implied opportunity costs of other people being born. We all think we're hot shit, but so did the people hundreds or thousands of years ago whose outlook and lifestyle makes us cringe or even puke in our mouth a little.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#29

Post by Torkel »

harles wrote: post #2

Can someone explain why this is interesting? It looks like a directionally interesting anti-aging study, but without any major breakthroughs. I'm curious what folks upvoting see in the study that I'm missing.

"Remarkably, the microenvironmental change and the functional decline of mid-old cells could be reversed by a young cell-originated protein, SLIT2. Our data identify functional reversion of mid-old cells as a potential method to prevent or ameliorate aspects of aging-related tissue dysfunction."

I think this sounds promising.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#30

Post by okr »

shiroiuma wrote: post #10
morbicer wrote: post #4

[flagged]

Exactly right. This is a total waste of time, and this effort should be spent on something more productive and useful for humanity, such as improving advertising technologies and preventing people from blocking or ignoring advertisements.

As i assume, you are being sarcastic, i would point to the effect, that certain endeavors, that bring money today (and to the content creators) finance the other endeavors, that dont bring in money just yet or maybe never. Thank you.
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