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Human embryo models grown from stem cells

wis-wander.weizmann.ac.il

21–30 of 95 posts

Re: Human embryo models grown from stem cells

#23

Reducing human suffering is a noble goal and infertile couples could benefit from this research. I would rather have western world make giant leaps in this field and also set the direction of ethics here rather than just banning it and leaving it up to Russia and China to conduct this sort of research in their secret facilities.

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Re: Human embryo models grown from stem cells

#24
post #11

That sounds to me like opening console and messing up with the website's JS code :D

Biologists have been messing with the console since a long time ago. They figured out what each gene does in large part by turning them off one by one, or occasionally making them run more than they should (overexpression). Even before they had the whole genome, they used random mutagenesis and slowly analyzed what got broken by breeding experiments. With enough data you can even locate it on a chromosome relative to known genes by linkage maps.

The most fun stuff to mess with is of course parts that controls how other stuff works. Figuring out what makes stem cells want to grow into shapes will lead us to more of these control switches.

Re: Human embryo models grown from stem cells

#26
post #6

It's one of the two publications that raised a controversy in June, for example discussed here: https://news.ycombinator.com/item?id=36330732 A summary on Nature news at the times: https://archive.ph/Xnx5n

Nice, the Nature news article links to the biorxiv version of three papers. The one linked by TFA is Oldak, https://doi.org/10.1101/2023.06.14.544922.

Re: Human embryo models grown from stem cells

#27

[flagged]

From an ethical standpoint, there is no reason to assert a human being created from re-embryonized adult stem cells should be any more enslaveable than any child of any parents or the younger of any pair of twins.

... of course, the flip-side of the coin is that for a certain segment of the pro-life movement, using these cells as test subjects will be equivalent to intentionally fertilizing human egg cells and then using those as test subjects.

Re: Human embryo models grown from stem cells

#28

Earlier quoted context omitted.

Signalling? Thank you for expanding my horizons. Could you please share some more? Even a link or two would suffice.

I am not expert but I think OP means different hormones would start to get produced and others would become suppressed to support the creation of a placenta, to support the the lining of the uterus and to cease ovulation and menstrual cycle as well as to start supporting the growing embryo in terms of nutrients by means of generating and connecting blood vessels. I read somewhere that pregnancy (unlike what is normal…

Preeclampsia is a condition where the fetus "requests" that the mother's body increase blood pressure to dangerous levels. It's definitely a case where one misbehaving could kill both the mother and the fetus.

Re: Human embryo models grown from stem cells

#30

Reducing human suffering is a noble goal and infertile couples could benefit from this research. I would rather have western world make giant leaps in this field and also set the direction of ethics here rather than just banning it and leaving it up to Russia and China to conduct this sort of research in their secret facilities.

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