Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Significant breakthrough in search for Parkinson's biomarker

michaeljfox.org

Post reply on HN
Print view View original

21–30 of 196 posts

Re: Significant breakthrough in search for Parkinson's biomarker

#21

Post by wyldfire »

lambdaba wrote: post #6

I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…

> 100 mg of thiamine administered intramuscularly twice a week

Is it possible to get anywhere near this much with dietary thiamine?

Re: Significant breakthrough in search for Parkinson's biomarker

#22

Post by meindnoch »

CoastalCoder wrote: post #15
nailer wrote: post #4

On a tangent, they also know the enzyme that causes SIDS and should have a testing program in place soon.

This sounds really interesting! Can you provide a link to more info?

"A 2022 study found that infants who died of SIDS exhibited significantly lower specific activity of butyrylcholinesterase, an enzyme involved in the brain's arousal pathway, shortly after birth. This can serve as a biomarker to identify infants with a potential autonomic cholinergic dysfunction and elevated risk for SIDS."

https://en.wikipedia.org/wiki/SIDS

Re: Significant breakthrough in search for Parkinson's biomarker

#23

Post by [deleted] »

wyldfire wrote: post #21
lambdaba wrote: post #6

I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…

> 100 mg of thiamine administered intramuscularly twice a week Is it possible to get anywhere near this much with dietary thiamine?

[deleted]

Re: Significant breakthrough in search for Parkinson's biomarker

#24

Post by melling »

EvanAnderson wrote: post #17
c3534l wrote: post #12

My grandmother had Parkinson's and it was awful. How long until I can go to the doctor, get some blood drawn, and see if I'll develop it one day?

What would you do if you found out you would? (I ask as someone whose great-grandfather, great-uncle, and grandfather all had Parkinson’s.) I’ve avoided any testing because, as far as I know, there’s nothing preventative to be done. I’d love to hear otherwise. I’ve broached the subject with my last two primary care physicians and both advised that there was no point in knowing.

Yes, the age old debate of knowing versus not knowing.

I think I’ll skip it because it’s not productive.

However, I will point out that your average billionaire with a few decades of advanced notice might be willing to fund research:

https://www.forbes.com/sites/kerryadolan/2022/12/09/exclusiv...

Re: Significant breakthrough in search for Parkinson's biomarker

#25

Post by shadowtree »

Interesting that big flu outbreaks cause a long term spike in Parkinson's - how much more will be traced back to the impact of viruses?

Saw that come up as a worry around Covid, seems the loss of smell/taste is a commonality with Parkison. We will not know for a decade or two though, but these biomarkers might help accelerate measuring the impact.

Re: Significant breakthrough in search for Parkinson's biomarker

#26

Post by nisegami »

EvanAnderson wrote: post #17
c3534l wrote: post #12

My grandmother had Parkinson's and it was awful. How long until I can go to the doctor, get some blood drawn, and see if I'll develop it one day?

What would you do if you found out you would? (I ask as someone whose great-grandfather, great-uncle, and grandfather all had Parkinson’s.) I’ve avoided any testing because, as far as I know, there’s nothing preventative to be done. I’d love to hear otherwise. I’ve broached the subject with my last two primary care physicians and both advised that there was no point in knowing.

I think if you find out young enough you can probably try to follow a different trajectory in life. Maybe abstain from stuff like finding a partner, having kids, buying a home or saving for retirement. Make plans to end up in circumstances where you're eligible for MAID and just vibe until you're ready to use it.

Re: Significant breakthrough in search for Parkinson's biomarker

#27

Post by c3534l »

EvanAnderson wrote: post #17
c3534l wrote: post #12

My grandmother had Parkinson's and it was awful. How long until I can go to the doctor, get some blood drawn, and see if I'll develop it one day?

What would you do if you found out you would? (I ask as someone whose great-grandfather, great-uncle, and grandfather all had Parkinson’s.) I’ve avoided any testing because, as far as I know, there’s nothing preventative to be done. I’d love to hear otherwise. I’ve broached the subject with my last two primary care physicians and both advised that there was no point in knowing.

That's a good question. I'm not sure. But it feels like something I'd want to either prepare myself for or just have the relief it won't happen to me.

Re: Significant breakthrough in search for Parkinson's biomarker

#28

Post by c3534l »

nisegami wrote: post #26
EvanAnderson wrote: post #17

Earlier quoted context omitted.

What would you do if you found out you would? (I ask as someone whose great-grandfather, great-uncle, and grandfather all had Parkinson’s.) I’ve avoided any testing because, as far as I know, there’s nothing preventative to be done. I’d love to hear otherwise. I’ve broached the subject with my last two primary care physicians and both advised that there was no point in knowing.

I think if you find out young enough you can probably try to follow a different trajectory in life. Maybe abstain from stuff like finding a partner, having kids, buying a home or saving for retirement. Make plans to end up in circumstances where you're eligible for MAID and just vibe until you're ready to use it.

Well, Michael J. Fox was diagnosed exceptionally young. Most people only suffer when they're of retired age.

Re: Significant breakthrough in search for Parkinson's biomarker

#29

Post by FollowingTheDao »

This is everything and nothing all at once.

Synucleinopathies are found in many neurological diseases. They even find it in Long COVID.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108014/

This is a marker for many diseases. They still have not found the trigger for Synucleinopathies, which I believe is a nutrient deficiency causing oxidative stress and zinc is at the top of my list.

https://academic.oup.com/hmg/article/23/11/2791/621896 https://academic.oup.com/brain/article/142/8/2380/5523051

By the way, this is the same reason peop[le loose their sense of smell with COVID. And I believe COVID is going to cause a rise in Parkinson's cases.

Re: Significant breakthrough in search for Parkinson's biomarker

#30

Post by oefnak »

cycomanic wrote: post #14
lambdaba wrote: post #6

I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…

https://www.michaeljfox.org/news/thiamine-vitamin-b1-and-par... The Michael J Fox foundation is more muted and says evidence is still missing. There have only been 2 trials and both were missing a placebo control group.

Imagine having Parkinsons and being in the placebo control group.
Post reply on HN