A mouse only lives 5 years so if we scale everything based on this to humans you’d have to be fasting for 16h * (80 years / 5 years) = 256h or nearly 11 days. You could be damn sure doing this regularly your gene expression would change. Of course basing the scaling this way is completely ridiculous but no less ridiculous than inferring anything about humans from the original study.
Time-restricted eating reshapes gene expression throughout the body
21–30 of 97 posts
Re: Time-restricted eating reshapes gene expression throughout the body
#22Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…
Agreed. Another additional benefit in my opinion is that when restricting your feeding window, it’s much easier to control cravings. When “free-eating”, it’s easy to just continue to snack.
Re: Time-restricted eating reshapes gene expression throughout the body
#23Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…
How did you test your A1C?
Re: Time-restricted eating reshapes gene expression throughout the body
#24Computational biologist with >5 years experience in analyzing RNAseq data like the one in the paper: I find 80% of genes being differentially expressed very hard to believe. You usually see such strong effects only when there are other sources of variation not being controlled for (e.g. batch effects) or when inducing an unphysiological state (e.g. treating with a cytotoxic drug).
Re: Time-restricted eating reshapes gene expression throughout the body
#25A mouse only lives 5 years so if we scale everything based on this to humans you’d have to be fasting for 16h * (80 years / 5 years) = 256h or nearly 11 days. You could be damn sure doing this regularly your gene expression would change. Of course basing the scaling this way is completely ridiculous but no less ridiculous than inferring anything about humans from the original study.
I see where you're coming from, but just because mice don't live as long as humans doesn't mean all biological processes happen 16x as fast. They don't defecate 16x as often as humans or sleep 16x per day.
Do you think there is 0 signal about potential impacts on humans from testing on mice? How would you prefer research be done with a similar cost, ability to control variables, & level of ethics?
Re: Time-restricted eating reshapes gene expression throughout the body
#26Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…
Is your 16:8 restricted to a full meal or did you consume or drink anything outside of the 16:8? After-work drinks? Coffee?
black coffee and plain tea are acceptable according to everything I’ve read, probably because they are close to 0 calories and certainly not nutritional calories if >0. So I drink them. Unfortunately there’s no way to know if you’re still in a fasted state after that coffee. You can test blood sugar with a pinprick and that is a marker, but not a guarantee.
To summarize: absolute safest is water only.
Re: Time-restricted eating reshapes gene expression throughout the body
#27I’ve been doing intermittent fasting for 2 years. Did a bunch of different protocols and eventually settled on ~18:6. Lost around 15kgs (from 105 to 90) and as a nice “side effect” got rid of all skin problems that I’d had during the previous 10 years or so. Today I don’t preach it anymore cause I got tired of debating whether it was healthy or not but I definitely recommend to everyone that’s truly interested in giv…
> ...got tired of debating whether it was healthy or not...
I've had a similar experience. "unhealthy" seems to often be used in place of "not normal."
I don't blame them. Advertising has been pushing "normal" food choices for 100+ years. Social gatherings are focused too much on eating. People are shamed for being "skin and bones."
I've been doing it for more than 10 years. I never get hunger pangs. I don't feel the need to eat something before leaving the house, or stopping at a drive-thru while out. I'm able to make better food choices. It doesn't mean I starve myself, or abstain from eating lunch/dinner with friends. I get all necessary calories for whatever my goals are (ie fat loss, maintenance, or weight gain).
Constant calorie intake from accessible food products designed to sit on store shelves for months should be considered not normal and unhealthy.
Re: Time-restricted eating reshapes gene expression throughout the body
#28Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…
16:8 is utterly unremarkable. A huge percent of people skip breakfast and then have dinner before 8pm. This is a normal, bog standard eating pattern.
In my experience, it's exceptional in America. This may be due to constant indoctrination that "breakfast is the most important meal of the day". Also, modern food processing has put all sorts of late-night snacks at our fingertips.
Re: Time-restricted eating reshapes gene expression throughout the body
#29Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…
> One group was given free access to the food. The other group was restricted to eating within a feeding window of nine hours each day.
Small correction: 15:9 pattern, if this writeup is correct.
Re: Time-restricted eating reshapes gene expression throughout the body
#30Computational biologist with >5 years experience in analyzing RNAseq data like the one in the paper: I find 80% of genes being differentially expressed very hard to believe. You usually see such strong effects only when there are other sources of variation not being controlled for (e.g. batch effects) or when inducing an unphysiological state (e.g. treating with a cytotoxic drug).
Have you considered that 16h for a mouse might, from a metabolic POV, be comparable to 4+ days in humans? That’d be quite the intervention.