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Fentanyl vaccine tested in rats

uh.edu

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Re: Fentanyl vaccine tested in rats

#21

Post by pazimzadeh »

shadowgovt wrote: post #9

This is a good time to remind people that https://twitter.com/justsaysinrats exists for a reason. ... and, indeed, the uh.edu article only tangentially indicates that the actual study ( https://www.mdpi.com/1999-4923/14/11/2290/htm ) has only been conducted in rats at this time. Interesting, but since it's brain chemistry we should be wary of getting too excited about the likelihood that this chemical pathway works s…

Isn't the whole point of doing it in rats that it's way more similar to humans than say Drosophila flies?

Somewhat related: has the result from the Rat Park experiment been debunked or shown not to apply in humans? https://en.wikipedia.org/wiki/Rat_Park

Re: Fentanyl vaccine tested in rats

#22

Post by version_five »

orblivion wrote: post #19

Flash reactions: * You could identify fentanyl passed off as heroin, cocaine, etc because they don't work as well. * "Damn this cocaine is weak. Maybe I need to take more" - I could imagine this leading to more fentanyl overdoses. * Something like this happened in neuromancer.

> Something like this happened in neuromancer.

Right, and Case bought betaphenethylamine instead of speed which was way harsher. That's exactly what is going to happen, some more potent drug that escapes the vaccine is going to get more popular. It's a bandaid solution that ignores the root cause (drug prohibition)

Re: Fentanyl vaccine tested in rats

#23

Post by kjkjadksj »

D13Fd wrote: post #8
mdanger007 wrote: post #3

Earlier quoted context omitted.

A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.

Yeah but my understanding is that most of the overdosing are from people seeking something else. In some cases it’s akin to a contamination problem.

We are at the point in the fentanyl epidemic where most users are specifically seeking out fentanyl or fentanyl laced drugs.

Re: Fentanyl vaccine tested in rats

#25

Post by elil17 »

armatav wrote: post #16

Watch this therapy disable the painkilling potential of every opioid in the body, including natural opioids.

The article actually discusses this:

“The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile.

Re: Fentanyl vaccine tested in rats

#26

Post by eddsh1994 »

DiabloD3 wrote: post #6
mdanger007 wrote: post #3

Earlier quoted context omitted.

A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.

Let's go another way with this: You are extremely unlikely to ever come across a fentanyl user, even if you work for law enforcement, even if you're a LEO in a major metro. 10x people died of heart attacks than any opioid, not only fentenyl, over the past few years. Almost as many people died of cancer as heart attacks, and half as many people died of COVID as cancer. Obviously, you can't equate research with other r…

Fentanyl is the leading cause of death for those aged 18 to 45 in the US. Seems pretty important to me. We can also look at the things you suggested, it's not like there's an Obesity OR Fentanyl choice here.

Re: Fentanyl vaccine tested in rats

#27

Post by kjkjadksj »

adamsmith143 wrote: post #4
mdanger007 wrote: post #3

Earlier quoted context omitted.

A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.

Is there some group of people who are taking fentanyl en masse intentionally? I know a few people who have died after taking what they thought were bars or ecstasy and died because it was laced with fentanyl. I know 0 who go out of their way to find and take fentanyl.

I would say most users now are taking the drug intentionally. I know of people who do seek out fent or fent laced drugs specifically. Its a lot cheaper to buy than heroin or any other opioid these days.

Re: Fentanyl vaccine tested in rats

#28

Post by elil17 »

ortusdux wrote: post #24

As I understand it, this would have significant negative impact on anesthesia.

Although fentanyl is used for anesthesia, especially for deep sedation, it is not the only option. From the article:

“The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile

So they could still use other opioids for anesthesia.

Re: Fentanyl vaccine tested in rats

#29

Post by elil17 »

orblivion wrote: post #19

Flash reactions: * You could identify fentanyl passed off as heroin, cocaine, etc because they don't work as well. * "Damn this cocaine is weak. Maybe I need to take more" - I could imagine this leading to more fentanyl overdoses. * Something like this happened in neuromancer.

Opioid overdoses are typically due how opioids effect the brain, so this would prevent fentanyl from contributing to and overdose.

Re: Fentanyl vaccine tested in rats

#30

Post by actionfromafar »

version_five wrote: post #22
orblivion wrote: post #19

Flash reactions: * You could identify fentanyl passed off as heroin, cocaine, etc because they don't work as well. * "Damn this cocaine is weak. Maybe I need to take more" - I could imagine this leading to more fentanyl overdoses. * Something like this happened in neuromancer.

> Something like this happened in neuromancer. Right, and Case bought betaphenethylamine instead of speed which was way harsher. That's exactly what is going to happen, some more potent drug that escapes the vaccine is going to get more popular. It's a bandaid solution that ignores the root cause (drug prohibition)

Wait, what? Selling fentanyl as candy in every street corner shop is going to fix this?
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