People will encounter the same kind of issue in Psychiatry. Because neuro-science is not advanced enough. Quite an interesting article.
Luck based medicine: my resentful story of becoming a medical miracle
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Re: Luck based medicine: my resentful story of becoming a medical miracle
#22Best to avoid doctors and make educated self-tests after internet/Google Scholar search.
Re: Luck based medicine: my resentful story of becoming a medical miracle
#23My experience with western medicine has been very black and white. Either you're completely broken and it's so obvious what's wrong with you that you barely need a doctor, or you're partially broken in which case doctors know very little and rely on experience, murky clues, and their gut. This made sense once I realized doctors know much less about the human body then they pretend to. Not only is our understanding of…
Re: Luck based medicine: my resentful story of becoming a medical miracle
#24Earlier quoted context omitted.
> Either you're completely broken and it's so obvious what's wrong with you that you barely need a doctor, or you're partially broken in which case doctors know very little and rely on experience, murky clues, and their gut. > This made sense once I realized doctors know much less about the human body then they pretend to. I find myself agreeing with this so strongly. Couldn't have put it better myself. Further - I'v…
> And there's such a strong force to silence criticism of the system This is partly because public discourse is incapable of nuance and because often those criticizing are in fact much much worse than the system being criticized. In the early years of the internet, we naively believed the interconnectedness of the internet would solve such things. Good will, honesty, and, proper information hygiene do not scale.
What does that say about "democracy" and collectivist politics more broadly?
Re: Luck based medicine: my resentful story of becoming a medical miracle
#25Boswelia, which helped this author, is frankincense. It's extremely reductive to call frankincense "an antihistamine"... There is a rich medical tradition of using frankincense for myriad treatments.
The author very narrowly cites BosPro,[1] which is a gum extract of Boswellia serrata, or Indian frankincense. Specifically, it claims to have high levels of AKBA (Acetyl-11-Keto-β-Boswellic Acid),[2] an antioxidant with vascular remodeling properties.[3]
It probably came up in Dr. Spray-n-pray's treatments because of studies that suggested AKBA could bind to SARS-CoV-2 proteins, but were inconclusive on whether they were effective treatments.[4]
The author dismisses the inspecific "inflammation" response from that doctor, but considering that the inflammations AKBA seems to often be found effective as a potential treatment are often related to either severe cardiac issues or neurological inflammation - including MS - I'm naively, but more than a little, concerned for the author.
The doctors might have understandably been focused on the author's digestive/GI health, but as noted in the article the brain/GI connection goes very deep. Early-onset symptoms of MS are often digestive in nature.[5]
1: https://www.euromedicausa.com/products/bospro/
2: https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-11-keto-bet...
3: https://www.nature.com/articles/srep39809
4: https://onlinelibrary.wiley.com/doi/10.1002/ardp.202100160
5: https://www.ms.pitt.edu/symptoms/stomach-and-intestinal-issu...
Re: Luck based medicine: my resentful story of becoming a medical miracle
#26People will encounter the same kind of issue in Psychiatry. Because neuro-science is not advanced enough. Quite an interesting article.
I've heard that because of insufficient microscopy, psychology is stuck at alchemy levels of understanding.
Psychiatrists, for lack of useful lab tests, must prescribe by trial and error. They have the additional problem that they use the same name for a variety of different illnesses. It would be like your mechanic says "busted" for all different failures, and just tries replacing random parts until one helps.
Re: Luck based medicine: my resentful story of becoming a medical miracle
#27Coming from a sciencey computer nerd background I have to say, plants are incredible. For one thing, they are very intelligent and adaptable. They have senses we don't fully understand. Together with fungi and microbes in soil they form LANs that administer large areas of the Earth and adjust environmental conditions to suit themselves. Seriously, look at living things as nanotechnology and you realize we are in (and of) a kind of living fractal cathedral of information and life.
Anyway, before I get too lyrical, my point is that plants produce myriad chemical substances that have effects on your metabolism. We are all familiar (if only by reputation) with the heavy hitters: Coffee, Coca, Cacao, Cannabis, (lotta C's) Tobacco, etc. But there are thousands of species of plants that produce innumerable substances that are essentially medicines: chemicals that have a stereotypical effect on metabolism.
It's entirely reasonable and unsurprising that some plant, such as Boswellia sacra, the sap of which is the source of frankincense, could have such an effect.
A well-stocked garden/forest is a medicine cabinet.
- - - -
As the author points out, it behooves us to "do science to it", eh?
When FitBit-style wearable medical monitoring devices become commonplace we're going to have a wealth of data to correlate, at least in theory.
Re: Luck based medicine: my resentful story of becoming a medical miracle
#28Boswelia, which helped this author, is frankincense. It's extremely reductive to call frankincense "an antihistamine"... There is a rich medical tradition of using frankincense for myriad treatments.
> Boswelia, which helped this author, is frankincense The author very narrowly cites BosPro,[1] which is a gum extract of Boswellia serrata, or Indian frankincense. Specifically, it claims to have high levels of AKBA (Acetyl-11-Keto-β-Boswellic Acid),[2] an antioxidant with vascular remodeling properties.[3] It probably came up in Dr. Spray-n-pray's treatments because of studies that suggested AKBA could bind to SARS…
MS is triggered by B-cell
Boswellic acid derivatives in true frankincense and Indian frankincense are both strongly medicinal.
The renin-angiotensin-aldosterone system, vasopressive intenstinal peptide-vasopressin regulatory axis, pinneal-thymic-bone marrow system, hypothalamic-pituitary system, and more are all significantly influenced by boswellia derivatives.
Re: Luck based medicine: my resentful story of becoming a medical miracle
#29My experience with western medicine has been very black and white. Either you're completely broken and it's so obvious what's wrong with you that you barely need a doctor, or you're partially broken in which case doctors know very little and rely on experience, murky clues, and their gut. This made sense once I realized doctors know much less about the human body then they pretend to. Not only is our understanding of…
I think of Western doctoring (diagnosis) as running an expert system. Like a game of twenty questions. If your specific conditions aren't found in your doctor's knowledge base, too bad. Maybe try another doctor, who has different experiences, different training. I've been lucky in that two of my doctors treated my rare conditions as mysteries, puzzles to be solved. Not much like House MD, which requires an explicit e…
My current goal in life is to save up enough that I can afford paying a private doctor to treat my chronic condition in exactly this way. Possibly in India or another place where it won't run into many hundreds of thousands of dollars. I still have no idea how I'm going to try and find one but your description has put it into words so aptly that I'm going to take it a8nnd run with it.
My condition has left me unable to use any kind of keyboard-like device except for MacBooks and any kind of mouse-like device with physical buttons (i.e. not trackpad). Using anything else hurts both my finger joints and wrist to the point that within minutes I need to stop using them. Yet with all the doctors I've seen here it's the same; 1. Do the scans and test 2. "Well we can see some inflammation in the wrist, you need to rest more. Here, we'll prescribe some NSAIDs.". Completely ignoring the absurdity of the suggestions given that it happens within minutes and having tried resetting things completely by disavowing keyboards/mouses for a few months to little effect when resuming usage.
> FWIW, in the USA, at least, the combo of fee-for-service and compensation model discourages sleuthing. (But does encourage more testing, ironically.) IMHO.
While that may be the case, I think you're still more likely to find a doctor willing to sleuth in the US than anywhere else. The cultural factor having an even bigger impact than the profit model. Having spent many years in both East-Asia and Western-Europe, each of them have cultural factors working very strongly against it even if their compensation models should be more favorable. For the former, a big aversion against debate/answer searching in general and particularly questioning an authority while doctors are as big as an authority as you can get, ranked at the very top of the hierarchy. For the latter, a big distrust of patients and high degree of expected "self-reliance".
Re: Luck based medicine: my resentful story of becoming a medical miracle
#30My experience with western medicine has been very black and white. Either you're completely broken and it's so obvious what's wrong with you that you barely need a doctor, or you're partially broken in which case doctors know very little and rely on experience, murky clues, and their gut. This made sense once I realized doctors know much less about the human body then they pretend to. Not only is our understanding of…
This last part, along with (from a comment elsewhere)
> [...] many doctors being terrible at statistics and failure to properly use statistics means they constantly overlook otherwise obvious causes.
means this area should be the one with dozens of AI startups chomping at the bit to improve the situation. I.e. giving suggestions for possible causes of rare medical issues. Because the existing human performance in these situations is so incredibly low mostly due to the exact things that ML models excel at, it should be very easy to at least to improve on that. If it's not happening because of US regulations against "medical advice", then base it in India or wherever it'll work. I guess that makes venture funding and profitability more difficult but if you're looking to do good, this avenue has unfathomably more potential for massive positive impact than e.g. taking a job at a traditional existing non-profit. I reckon it should also be very possible to get funding from exactly such non-profits, especially those aimed at rare medical conditions. Effective altruism-oriented groups should also be interested.
If the issue is the unobtainability of data due to privacy laws, even a ChatGPT-like model trained purely on Google Scholar, medical literature and other relevant sources has enormous potential and again should readily outperform the baseline.