It's time to write the eulogy for application automation and inter-application communication on the Mac. AppleScript (beast that it is) was innovative when it was created, and still has not been replaced. Automator is built on AppleEvents, and with sandboxing will come a sharp decline in the number of applications that can receive AppleEvents and the extinction of apps that send them.
Not at all! Sandboxing brings with it XPC, which is an IPC framework for doing very fast and awesome message passing. It's got some great features for separation of privileges. For instance, you might have an XPC sandboxed process for, say, rendering a H.264 video to a buffer. That process never gets access to the filesystem, the graphics card, or anything apart from the strip of memory that contains the file, and th…
That's kinda cool... never tried that before.
But yeah. Sandboxing does not at all imply not-scriptable. It tends to imply breakage with older systems of scripting, but that's about all, and only until wrappers are made.